Progression to invasive melanoma frommalignant melanoma in situ, lentigo maligna type
We have previously hypothesized that lesions that have been termed lentigo maligna can be divided into 2 categories: 1 represents a pigmented lesion that is a precursor to melanoma, and the other melanoma in situ. We and others have hypothesized that there is a progressive acquisition of attributes...
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| مؤلفون آخرون: | , , , |
| التنسيق: | article |
| منشور في: |
2000
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/6544 https://doi.org/10.1053/hupa.2000.7640 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.sciencedirect.com/science/article/pii/S0046817700801136 |
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| _version_ | 1864513480207368192 |
|---|---|
| author | Tannous, Zeina |
| author2 | Lerner, Lisa H. Duncan, Lyn M. Mihim, Martin C. Flotte, Thomas |
| author2_role | author author author author |
| author_facet | Tannous, Zeina Lerner, Lisa H. Duncan, Lyn M. Mihim, Martin C. Flotte, Thomas |
| author_role | author |
| dc.creator.none.fl_str_mv | Tannous, Zeina Lerner, Lisa H. Duncan, Lyn M. Mihim, Martin C. Flotte, Thomas |
| dc.date.none.fl_str_mv | 2000 2017-11-08T09:24:22Z 2017-11-08T09:24:22Z 2017-11-08 |
| dc.identifier.none.fl_str_mv | 1532-8392 http://hdl.handle.net/10725/6544 https://doi.org/10.1053/hupa.2000.7640 Tannous, Z. S., Lerner, L. H., Duncan, L. M., Mihm, M. C., & Flotte, T. J. (2000). Progression to invasive melanoma frommalignant melanoma in situ, lentigo maligna type. Human pathology, 31(6), 705-708. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.sciencedirect.com/science/article/pii/S0046817700801136 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Progression to invasive melanoma frommalignant melanoma in situ, lentigo maligna type |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Progression to invasive melanoma frommalignant melanoma in situ, lentigo maligna type |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | We have previously hypothesized that lesions that have been termed lentigo maligna can be divided into 2 categories: 1 represents a pigmented lesion that is a precursor to melanoma, and the other melanoma in situ. We and others have hypothesized that there is a progressive acquisition of attributes in pigmented lesions that results in malignant melanoma. Based on these 2 hypotheses, we have predicted that the intraepidermal component of invasive malignant melanomas, lentigo maligna type, should be similar to those lesions that we have termed malignant melanoma in situ, lentigo maligna type rather than lentigo maligna. The intraepidermal component of 42 consecutive cases of invasive malignant melanoma, lentigo maligna type was evaluated by all of the authors. Malignant melanoma in situ, lentigo maligna type is characterized by pagetoid spread, confluence, and nesting of atypical melanocytes. All of the cases evaluated showed features diagnostic of malignant melanoma in situ, lentigo maligna type, in the epidermis overlying the invasive dermal component. We conclude that invasive lentigo maligna melanoma arises in association with those lesions that we have termed malignant melanoma in situ, lentigo maligna type, which may represent a step in the progression between atypical melanocytic hyperplasia (lentigo maligna) and invasive melanoma. This fording supports the distinction of these entities and may have therapeutic implications. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_9f42edb1d90f596bcf529140fc6c7dae |
| identifier_str_mv | 1532-8392 Tannous, Z. S., Lerner, L. H., Duncan, L. M., Mihm, M. C., & Flotte, T. J. (2000). Progression to invasive melanoma frommalignant melanoma in situ, lentigo maligna type. Human pathology, 31(6), 705-708. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/6544 |
| publishDate | 2000 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Progression to invasive melanoma frommalignant melanoma in situ, lentigo maligna typeTannous, ZeinaLerner, Lisa H.Duncan, Lyn M.Mihim, Martin C.Flotte, ThomasWe have previously hypothesized that lesions that have been termed lentigo maligna can be divided into 2 categories: 1 represents a pigmented lesion that is a precursor to melanoma, and the other melanoma in situ. We and others have hypothesized that there is a progressive acquisition of attributes in pigmented lesions that results in malignant melanoma. Based on these 2 hypotheses, we have predicted that the intraepidermal component of invasive malignant melanomas, lentigo maligna type, should be similar to those lesions that we have termed malignant melanoma in situ, lentigo maligna type rather than lentigo maligna. The intraepidermal component of 42 consecutive cases of invasive malignant melanoma, lentigo maligna type was evaluated by all of the authors. Malignant melanoma in situ, lentigo maligna type is characterized by pagetoid spread, confluence, and nesting of atypical melanocytes. All of the cases evaluated showed features diagnostic of malignant melanoma in situ, lentigo maligna type, in the epidermis overlying the invasive dermal component. We conclude that invasive lentigo maligna melanoma arises in association with those lesions that we have termed malignant melanoma in situ, lentigo maligna type, which may represent a step in the progression between atypical melanocytic hyperplasia (lentigo maligna) and invasive melanoma. This fording supports the distinction of these entities and may have therapeutic implications.PublishedN/A2017-11-08T09:24:22Z2017-11-08T09:24:22Z20002017-11-08Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1532-8392http://hdl.handle.net/10725/6544https://doi.org/10.1053/hupa.2000.7640Tannous, Z. S., Lerner, L. H., Duncan, L. M., Mihm, M. C., & Flotte, T. J. (2000). Progression to invasive melanoma frommalignant melanoma in situ, lentigo maligna type. Human pathology, 31(6), 705-708.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttp://www.sciencedirect.com/science/article/pii/S0046817700801136enProgression to invasive melanoma frommalignant melanoma in situ, lentigo maligna typeinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/65442021-03-19T10:03:27Z |
| spellingShingle | Progression to invasive melanoma frommalignant melanoma in situ, lentigo maligna type Tannous, Zeina |
| status_str | publishedVersion |
| title | Progression to invasive melanoma frommalignant melanoma in situ, lentigo maligna type |
| title_full | Progression to invasive melanoma frommalignant melanoma in situ, lentigo maligna type |
| title_fullStr | Progression to invasive melanoma frommalignant melanoma in situ, lentigo maligna type |
| title_full_unstemmed | Progression to invasive melanoma frommalignant melanoma in situ, lentigo maligna type |
| title_short | Progression to invasive melanoma frommalignant melanoma in situ, lentigo maligna type |
| title_sort | Progression to invasive melanoma frommalignant melanoma in situ, lentigo maligna type |
| url | http://hdl.handle.net/10725/6544 https://doi.org/10.1053/hupa.2000.7640 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.sciencedirect.com/science/article/pii/S0046817700801136 |