Hepatoprotective activity of the wild carrot chloroform-based fraction against CCl4-induced liver toxicity in mice
The liver plays a major role in detoxifying and clearing xenobiotics that may lead to liver damage and hepatic dysfunction. The present study was carried out to evaluate the hepatoprotective activities of the chloroform-based fraction of wild carrot (Daucus carota L. ssp. carota; Apiacae) on CCl4-in...
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2014
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| Online Access: | http://hdl.handle.net/10725/7425 http://dx.doi.org/10.1055/s-0034-1395009 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0034-1395009 |
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| _version_ | 1864513482133602304 |
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| author | Shebaby, W. |
| author2 | El-Sibai, M. Mroueh, M. Bodman-Smith, K. Taleb, R. Daher, C. |
| author2_role | author author author author author |
| author_facet | Shebaby, W. El-Sibai, M. Mroueh, M. Bodman-Smith, K. Taleb, R. Daher, C. |
| author_role | author |
| dc.creator.none.fl_str_mv | Shebaby, W. El-Sibai, M. Mroueh, M. Bodman-Smith, K. Taleb, R. Daher, C. |
| dc.date.none.fl_str_mv | 2014 2018-04-19T09:21:11Z 2018-04-19T09:21:11Z 2018-04-19 |
| dc.identifier.none.fl_str_mv | 1439-0221 http://hdl.handle.net/10725/7425 http://dx.doi.org/10.1055/s-0034-1395009 Shebaby, W., El-Sibai, M., Mroueh, M., Bodman-Smith, K., Taleb, R., & Daher, C. (2014). Hepatoprotective activity of the wild carrot chloroform-based fraction against CCl4-induced liver toxicity in mice. Planta Medica, 80(16), P2O16. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0034-1395009 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Planta Medica |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Hepatoprotective activity of the wild carrot chloroform-based fraction against CCl4-induced liver toxicity in mice |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | The liver plays a major role in detoxifying and clearing xenobiotics that may lead to liver damage and hepatic dysfunction. The present study was carried out to evaluate the hepatoprotective activities of the chloroform-based fraction of wild carrot (Daucus carota L. ssp. carota; Apiacae) on CCl4-induced liver damage in BALB/c mice. Liver damage was induced by intraperitoneal injection of CCl4 at a dose of 1 ml/kg body weight. Animals were treated with different doses of the extract (50, 100 and 200 mg/kg body weight). Serum and liver homogenate supernatants were analyzed for marker enzymes aspartate transaminase (AST), alanine transaminase (ALT), catalase (CAT), superoxide dismutase (SOD) and glutathione S-transferase (GST) activities. Pretreated groups with chloroform-based fraction reduced significantly the serum levels of AST and ALT. It also reversed the CCl4-induced decrease in SOD, CAT and GST levels thereby reducing significantly hepatic damage. HPLC analysis revealed that the chloroform-based fraction was rich in polyphenolic compounds such as luteolin, kaempferol, apigenin and quercetin, which could be partially responsible for the hepatoprotective effect. The current results suggest that chloroform-based fraction possess strong hepatoprotective activity against CCl4 induced liver damage at all doses used |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_a01494bb697af7bb6367f9dffa976887 |
| identifier_str_mv | 1439-0221 Shebaby, W., El-Sibai, M., Mroueh, M., Bodman-Smith, K., Taleb, R., & Daher, C. (2014). Hepatoprotective activity of the wild carrot chloroform-based fraction against CCl4-induced liver toxicity in mice. Planta Medica, 80(16), P2O16. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/7425 |
| publishDate | 2014 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Hepatoprotective activity of the wild carrot chloroform-based fraction against CCl4-induced liver toxicity in miceShebaby, W.El-Sibai, M.Mroueh, M.Bodman-Smith, K.Taleb, R.Daher, C.The liver plays a major role in detoxifying and clearing xenobiotics that may lead to liver damage and hepatic dysfunction. The present study was carried out to evaluate the hepatoprotective activities of the chloroform-based fraction of wild carrot (Daucus carota L. ssp. carota; Apiacae) on CCl4-induced liver damage in BALB/c mice. Liver damage was induced by intraperitoneal injection of CCl4 at a dose of 1 ml/kg body weight. Animals were treated with different doses of the extract (50, 100 and 200 mg/kg body weight). Serum and liver homogenate supernatants were analyzed for marker enzymes aspartate transaminase (AST), alanine transaminase (ALT), catalase (CAT), superoxide dismutase (SOD) and glutathione S-transferase (GST) activities. Pretreated groups with chloroform-based fraction reduced significantly the serum levels of AST and ALT. It also reversed the CCl4-induced decrease in SOD, CAT and GST levels thereby reducing significantly hepatic damage. HPLC analysis revealed that the chloroform-based fraction was rich in polyphenolic compounds such as luteolin, kaempferol, apigenin and quercetin, which could be partially responsible for the hepatoprotective effect. The current results suggest that chloroform-based fraction possess strong hepatoprotective activity against CCl4 induced liver damage at all doses usedPublishedN/A2018-04-19T09:21:11Z2018-04-19T09:21:11Z20142018-04-19Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1439-0221http://hdl.handle.net/10725/7425http://dx.doi.org/10.1055/s-0034-1395009Shebaby, W., El-Sibai, M., Mroueh, M., Bodman-Smith, K., Taleb, R., & Daher, C. (2014). Hepatoprotective activity of the wild carrot chloroform-based fraction against CCl4-induced liver toxicity in mice. Planta Medica, 80(16), P2O16.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0034-1395009enPlanta Medicainfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/74252024-01-30T13:33:56Z |
| spellingShingle | Hepatoprotective activity of the wild carrot chloroform-based fraction against CCl4-induced liver toxicity in mice Shebaby, W. |
| status_str | publishedVersion |
| title | Hepatoprotective activity of the wild carrot chloroform-based fraction against CCl4-induced liver toxicity in mice |
| title_full | Hepatoprotective activity of the wild carrot chloroform-based fraction against CCl4-induced liver toxicity in mice |
| title_fullStr | Hepatoprotective activity of the wild carrot chloroform-based fraction against CCl4-induced liver toxicity in mice |
| title_full_unstemmed | Hepatoprotective activity of the wild carrot chloroform-based fraction against CCl4-induced liver toxicity in mice |
| title_short | Hepatoprotective activity of the wild carrot chloroform-based fraction against CCl4-induced liver toxicity in mice |
| title_sort | Hepatoprotective activity of the wild carrot chloroform-based fraction against CCl4-induced liver toxicity in mice |
| url | http://hdl.handle.net/10725/7425 http://dx.doi.org/10.1055/s-0034-1395009 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0034-1395009 |