Formulation parameters and release mechanism of theophylline loaded ethyl cellulose microspheres
Altering the combined hydrophilic-lipophilic balance (CHLB), by varying the ratio of dual surfactants, on formulation parameters and in vitro drug release of ethyl cellulose microspheres was examined. Theophylline, a xanthine bronchodilator was used to model controlled release owing to its narrow th...
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| مؤلفون آخرون: | , , , , , , |
| التنسيق: | article |
| منشور في: |
2011
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/6330 http://dx.doi.org/10.3109/10837450.2011.620969 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.tandfonline.com/doi/abs/10.3109/10837450.2011.620969 |
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| _version_ | 1864513479004651520 |
|---|---|
| author | Capomacchia, Anthony C. |
| author2 | Thakare, Mohan Graner, Solomon T. Ahmed, Hisham Graner, Pamela Elder, Deborah Price, James C. Israel, Bridgette |
| author2_role | author author author author author author author |
| author_facet | Capomacchia, Anthony C. Thakare, Mohan Graner, Solomon T. Ahmed, Hisham Graner, Pamela Elder, Deborah Price, James C. Israel, Bridgette |
| author_role | author |
| dc.creator.none.fl_str_mv | Capomacchia, Anthony C. Thakare, Mohan Graner, Solomon T. Ahmed, Hisham Graner, Pamela Elder, Deborah Price, James C. Israel, Bridgette |
| dc.date.none.fl_str_mv | 2011 2017-10-17T11:03:08Z 2017-10-17T11:03:08Z 2017-10-17 |
| dc.identifier.none.fl_str_mv | 1097-9867 http://hdl.handle.net/10725/6330 http://dx.doi.org/10.3109/10837450.2011.620969 Thakare, M., Israel, B., Garner, S. T., Ahmed, H., Garner, P., Elder, D., ... & Capomacchia, A. C. (2013). Formulation parameters and release mechanism of theophylline loaded ethyl cellulose microspheres: effect of different dual surfactant ratios. Pharmaceutical development and technology, 18(5), 1213-1219. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.tandfonline.com/doi/abs/10.3109/10837450.2011.620969 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Pharmaceutical Development and Technology |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Formulation parameters and release mechanism of theophylline loaded ethyl cellulose microspheres effect of different dual surfactant ratios |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Altering the combined hydrophilic-lipophilic balance (CHLB), by varying the ratio of dual surfactants, on formulation parameters and in vitro drug release of ethyl cellulose microspheres was examined. Theophylline, a xanthine bronchodilator was used to model controlled release owing to its narrow therapeutic index. Microspheres were prepared using different ratios of dual surfactant in an emulsion-solvent evaporation process. Drug loading, encapsulation efficiency, particle size distribution, and geometric mean diameters were evaluated. Drug release was evaluated using several kinetic models including zero and first order, Higuchi square root, and Hixson-Crowell. Microspheres presented as mostly spherical particles and diffusional drug release was affected by microsphere construction. For this novel, dual surfactant system the microsphere matrix is a hydrophobic polymer and the release rate may be modulated with variation in ratio of dual surfactants. Dissolution data followed the Higuchi model and supports the formation of a monolithic microsphere matrix that releases theophylline by Fickian diffusion. Dual surfactants for preparation of microspheres are an inadequately studied research area that offers another means to modulate particle size and drug release. For the current study microspheres prepared with surfactant ratios of Span 65: Tween 40 between 3:1 and 2:1 provided the best control of size and drug release. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_a2bf5270bf1dc05359352f0b7d115de4 |
| identifier_str_mv | 1097-9867 Thakare, M., Israel, B., Garner, S. T., Ahmed, H., Garner, P., Elder, D., ... & Capomacchia, A. C. (2013). Formulation parameters and release mechanism of theophylline loaded ethyl cellulose microspheres: effect of different dual surfactant ratios. Pharmaceutical development and technology, 18(5), 1213-1219. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/6330 |
| publishDate | 2011 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Formulation parameters and release mechanism of theophylline loaded ethyl cellulose microsphereseffect of different dual surfactant ratiosCapomacchia, Anthony C.Thakare, MohanGraner, Solomon T.Ahmed, HishamGraner, PamelaElder, DeborahPrice, James C.Israel, BridgetteAltering the combined hydrophilic-lipophilic balance (CHLB), by varying the ratio of dual surfactants, on formulation parameters and in vitro drug release of ethyl cellulose microspheres was examined. Theophylline, a xanthine bronchodilator was used to model controlled release owing to its narrow therapeutic index. Microspheres were prepared using different ratios of dual surfactant in an emulsion-solvent evaporation process. Drug loading, encapsulation efficiency, particle size distribution, and geometric mean diameters were evaluated. Drug release was evaluated using several kinetic models including zero and first order, Higuchi square root, and Hixson-Crowell. Microspheres presented as mostly spherical particles and diffusional drug release was affected by microsphere construction. For this novel, dual surfactant system the microsphere matrix is a hydrophobic polymer and the release rate may be modulated with variation in ratio of dual surfactants. Dissolution data followed the Higuchi model and supports the formation of a monolithic microsphere matrix that releases theophylline by Fickian diffusion. Dual surfactants for preparation of microspheres are an inadequately studied research area that offers another means to modulate particle size and drug release. For the current study microspheres prepared with surfactant ratios of Span 65: Tween 40 between 3:1 and 2:1 provided the best control of size and drug release.PublishedN/A2017-10-17T11:03:08Z2017-10-17T11:03:08Z20112017-10-17Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1097-9867http://hdl.handle.net/10725/6330http://dx.doi.org/10.3109/10837450.2011.620969Thakare, M., Israel, B., Garner, S. T., Ahmed, H., Garner, P., Elder, D., ... & Capomacchia, A. C. (2013). Formulation parameters and release mechanism of theophylline loaded ethyl cellulose microspheres: effect of different dual surfactant ratios. Pharmaceutical development and technology, 18(5), 1213-1219.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttp://www.tandfonline.com/doi/abs/10.3109/10837450.2011.620969enPharmaceutical Development and Technologyinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/63302021-03-19T10:03:25Z |
| spellingShingle | Formulation parameters and release mechanism of theophylline loaded ethyl cellulose microspheres Capomacchia, Anthony C. |
| status_str | publishedVersion |
| title | Formulation parameters and release mechanism of theophylline loaded ethyl cellulose microspheres |
| title_full | Formulation parameters and release mechanism of theophylline loaded ethyl cellulose microspheres |
| title_fullStr | Formulation parameters and release mechanism of theophylline loaded ethyl cellulose microspheres |
| title_full_unstemmed | Formulation parameters and release mechanism of theophylline loaded ethyl cellulose microspheres |
| title_short | Formulation parameters and release mechanism of theophylline loaded ethyl cellulose microspheres |
| title_sort | Formulation parameters and release mechanism of theophylline loaded ethyl cellulose microspheres |
| url | http://hdl.handle.net/10725/6330 http://dx.doi.org/10.3109/10837450.2011.620969 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.tandfonline.com/doi/abs/10.3109/10837450.2011.620969 |