Characterization of the potency and mechanism of action of a novel dual-selective intermolecularly complemented version of Anthrax Lethal Toxin (PAU2R200A- PAL1I207R/FP59) in Acute myeloid leukemia

Anthrax lethal toxin (PrAg/LF) is a binary toxin consisting of protective antigen (PrAg), the cell binding moiety, and lethal factor (LF), the catalytic moiety. Inside the cell, LF cleaves MEKs and subsequently leads to the inhibition of the MAPK pathway causing cell death. Due to its off-target tox...

وصف كامل

محفوظ في:

التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Farhat, Mirna (author)
التنسيق:	masterThesis
منشور في:	2023
الموضوعات:	Acute myeloid leukemia > Pathogensis Mitogen-activated protein kinases Blood > Diseases > Molecular aspects Anthrax Lebanese American University > Dissertations Dissertations, Academic
الوصول للمادة أونلاين:	http://hdl.handle.net/10725/15130 https://doi.org/10.26756/th.2023.615 http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php
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Characterization of the potency and mechanism of action of a novel dual-selective intermolecularly complemented version of Anthrax Lethal Toxin (PAU2R200A- PAL1I207R/FP59) in Acute myeloid leukemia

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