Characterization of the potency and mechanism of action of a novel dual-selective intermolecularly complemented version of Anthrax Lethal Toxin (PAU2R200A- PAL1I207R/FP59) in Acute myeloid leukemia

Characterization of the potency and mechanism of action of a novel dual-selective intermolecularly complemented version of Anthrax Lethal Toxin (PAU2R200A- PAL1I207R/FP59) in Acute myeloid leukemia

Anthrax lethal toxin (PrAg/LF) is a binary toxin consisting of protective antigen (PrAg), the cell binding moiety, and lethal factor (LF), the catalytic moiety. Inside the cell, LF cleaves MEKs and subsequently leads to the inhibition of the MAPK pathway causing cell death. Due to its off-target tox...

Full description

Saved in:
Bibliographic Details
Main Author: Farhat, Mirna (author)
Format: masterThesis
Published: 2023
Subjects:
Acute myeloid leukemia > Pathogensis
Mitogen-activated protein kinases
Blood > Diseases > Molecular aspects
Anthrax
Lebanese American University > Dissertations
Dissertations, Academic
Online Access:http://hdl.handle.net/10725/15130
https://doi.org/10.26756/th.2023.615
http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://hdl.handle.net/10725/15130
https://doi.org/10.26756/th.2023.615
http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php

Similar Items