α-ketoglutarate (αKG) acts as a protective factor against chronic stress and has antidepressant properties by modulating BDNF levels in the brain
Major depression and anxiety are one of the most common mental disorders worldwide. Attempts to alleviate these mental burdens are usually through psycho-therapeutic approaches, but little focus has been placed on lifestyle modifications. Adoption of these modifications, such as physical exercise, i...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| التنسيق: | masterThesis |
| منشور في: |
2022
|
| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/13881 https://doi.org/10.26756/th.2022.393 http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513468355313664 |
|---|---|
| author | Eid, Fady |
| author_facet | Eid, Fady |
| author_role | author |
| dc.creator.none.fl_str_mv | Eid, Fady |
| dc.date.none.fl_str_mv | 2022-07-26T11:46:26Z 2022-07-26T11:46:26Z 2022 2022-05-16 |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10725/13881 https://doi.org/10.26756/th.2022.393 http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Lebanese American University |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Mental illness -- Treatment Depression, Mental -- Treatment Antidepressants -- Physiological effect Lebanese American University -- Dissertations Dissertations, Academic |
| dc.title.none.fl_str_mv | α-ketoglutarate (αKG) acts as a protective factor against chronic stress and has antidepressant properties by modulating BDNF levels in the brain |
| dc.type.none.fl_str_mv | Thesis info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/masterThesis |
| description | Major depression and anxiety are one of the most common mental disorders worldwide. Attempts to alleviate these mental burdens are usually through psycho-therapeutic approaches, but little focus has been placed on lifestyle modifications. Adoption of these modifications, such as physical exercise, improved dietary intake, and proper sleep, have served as a nexus between clinical treatments as well as general health promotion. A multitude of studies points to how physical exercise has positive outcomes on depression and anxiety via the induction of a neurotrophic factor known as brain-derived neurotrophic factor (BDNF). α-ketoglutarate (aKG) was recently identified as a factor that is released into the blood upon exercise. In this study, we investigated whether aKG has prophylactic and antidepressant effects in chronic social defeat stress and chronic variable stress models of depression, as well as unravel the underlying molecular mechanisms. Our work shows that aKG serves as a potential prophylactic treatment for depression in both males and females through the modulation of BDNF in specific brain regions. In males, aKG pretreatment promotes resilience to stress via the PGC1a-BDNF axis within the hippocampus. Moreover, aKG exhibited antidepressant effects in susceptible female mice by modulating BDNF levels. In the hippocampus, aKG increases BDNF levels possibly through the PGC1a-BDNF pathway. In the NAc, aKG decreases BDNF levels possibly through the FNDC5-BDNF pathway. |
| eu_rights_str_mv | openAccess |
| format | masterThesis |
| id | LAURepo_a5000de507bc2bbd0d2855263e0919dd |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/13881 |
| publishDate | 2022 |
| publisher.none.fl_str_mv | Lebanese American University |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | α-ketoglutarate (αKG) acts as a protective factor against chronic stress and has antidepressant properties by modulating BDNF levels in the brainEid, FadyMental illness -- TreatmentDepression, Mental -- TreatmentAntidepressants -- Physiological effectLebanese American University -- DissertationsDissertations, AcademicMajor depression and anxiety are one of the most common mental disorders worldwide. Attempts to alleviate these mental burdens are usually through psycho-therapeutic approaches, but little focus has been placed on lifestyle modifications. Adoption of these modifications, such as physical exercise, improved dietary intake, and proper sleep, have served as a nexus between clinical treatments as well as general health promotion. A multitude of studies points to how physical exercise has positive outcomes on depression and anxiety via the induction of a neurotrophic factor known as brain-derived neurotrophic factor (BDNF). α-ketoglutarate (aKG) was recently identified as a factor that is released into the blood upon exercise. In this study, we investigated whether aKG has prophylactic and antidepressant effects in chronic social defeat stress and chronic variable stress models of depression, as well as unravel the underlying molecular mechanisms. Our work shows that aKG serves as a potential prophylactic treatment for depression in both males and females through the modulation of BDNF in specific brain regions. In males, aKG pretreatment promotes resilience to stress via the PGC1a-BDNF axis within the hippocampus. Moreover, aKG exhibited antidepressant effects in susceptible female mice by modulating BDNF levels. In the hippocampus, aKG increases BDNF levels possibly through the PGC1a-BDNF pathway. In the NAc, aKG decreases BDNF levels possibly through the FNDC5-BDNF pathway.1 online resource (xi, 56 leaves): ill.Includes bibliographical references (leaf 44-56)Lebanese American University2022-07-26T11:46:26Z2022-07-26T11:46:26Z20222022-05-16Thesisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesishttp://hdl.handle.net/10725/13881https://doi.org/10.26756/th.2022.393http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.phpeninfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/138812022-08-23T06:45:42Z |
| spellingShingle | α-ketoglutarate (αKG) acts as a protective factor against chronic stress and has antidepressant properties by modulating BDNF levels in the brain Eid, Fady Mental illness -- Treatment Depression, Mental -- Treatment Antidepressants -- Physiological effect Lebanese American University -- Dissertations Dissertations, Academic |
| status_str | publishedVersion |
| title | α-ketoglutarate (αKG) acts as a protective factor against chronic stress and has antidepressant properties by modulating BDNF levels in the brain |
| title_full | α-ketoglutarate (αKG) acts as a protective factor against chronic stress and has antidepressant properties by modulating BDNF levels in the brain |
| title_fullStr | α-ketoglutarate (αKG) acts as a protective factor against chronic stress and has antidepressant properties by modulating BDNF levels in the brain |
| title_full_unstemmed | α-ketoglutarate (αKG) acts as a protective factor against chronic stress and has antidepressant properties by modulating BDNF levels in the brain |
| title_short | α-ketoglutarate (αKG) acts as a protective factor against chronic stress and has antidepressant properties by modulating BDNF levels in the brain |
| title_sort | α-ketoglutarate (αKG) acts as a protective factor against chronic stress and has antidepressant properties by modulating BDNF levels in the brain |
| topic | Mental illness -- Treatment Depression, Mental -- Treatment Antidepressants -- Physiological effect Lebanese American University -- Dissertations Dissertations, Academic |
| url | http://hdl.handle.net/10725/13881 https://doi.org/10.26756/th.2022.393 http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php |