Regulation of Class IA PI 3-kinases

We previously proposed a model of Class IA PI3K regulation in which p85 inhibition of p110α requires (i) an inhibitory contact between the p85 nSH2 domain and the p110α helical domain, and (ii) a contact between the p85 nSH2 and iSH2 domains that orients the nSH2 so as to inhibit p110α. We proposed...

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Bibliographic Details
Main Author:	Wu, Haiyan (author)
Other Authors:	Shekar, S. Chandra (author), Flinn, Rory J. (author), El-Sibai, Mirvat (author), Jaiswal, Bijay S. (author), Sen, K. Ilker (author), Janakiraman, Vasantharajan (author), Seshagiri, Somasekar (author), Gerfen, Gary J. (author), Girvin, Mark E. (author), Backer, Jonathan M. (author)
Format:	article
Published:	2009
Online Access:	http://hdl.handle.net/10725/2437 http://dx.doi.org/10.1073/pnas.0902369106 http://www.pnas.org/content/106/48/20258.short
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Regulation of Class IA PI 3-kinases

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