Distribution of Killer Cell Immunoglobulin–like Receptor (KIR) Genotypes in Patients with Familial Mediterranean Fever
Genotypic profiles of the natural killer cell immunoglobulin–like receptors (KIR) have been reported to vary among different ethnic groups and variable clinical entities. This study represents the first report on its distribution among patients with familial Mediterranean fever (FMF). We studied 56...
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2009
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| Online Access: | http://hdl.handle.net/10725/3356 http://dx.doi.org/10.1089/gtmb.2008.0081 http://online.liebertpub.com/doi/pdf/10.1089/gtmb.2008.0081 |
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| _version_ | 1864513461005844480 |
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| author | Khazen, Georges |
| author2 | Khalaf, Roy A. Mahfouz, Rami A.R. Sabbagh, Amira S. Shamseddine, Wael Bazarbachi, Ali |
| author2_role | author author author author author |
| author_facet | Khazen, Georges Khalaf, Roy A. Mahfouz, Rami A.R. Sabbagh, Amira S. Shamseddine, Wael Bazarbachi, Ali |
| author_role | author |
| dc.creator.none.fl_str_mv | Khazen, Georges Khalaf, Roy A. Mahfouz, Rami A.R. Sabbagh, Amira S. Shamseddine, Wael Bazarbachi, Ali |
| dc.date.none.fl_str_mv | 2009 2016-03-17T13:17:00Z 2016-03-17T13:17:00Z 2016-03-17 |
| dc.identifier.none.fl_str_mv | 1945-0265 http://hdl.handle.net/10725/3356 http://dx.doi.org/10.1089/gtmb.2008.0081 Mahfouz, R. A., Sabbagh, A. S., Shamseddine, W., Bazarbachi, A., Ibrahim, G., Arayssi, T., ... & Khalaf, R. A. (2009). Distribution of Killer Cell Immunoglobulin–like Receptor (KIR) Genotypes in Patients with Familial Mediterranean Fever. Genetic testing and molecular biomarkers, 13(1), 91-95. http://online.liebertpub.com/doi/pdf/10.1089/gtmb.2008.0081 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Genetic Testing and Molecular Biomarkers |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Distribution of Killer Cell Immunoglobulin–like Receptor (KIR) Genotypes in Patients with Familial Mediterranean Fever |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Genotypic profiles of the natural killer cell immunoglobulin–like receptors (KIR) have been reported to vary among different ethnic groups and variable clinical entities. This study represents the first report on its distribution among patients with familial Mediterranean fever (FMF). We studied 56 unrelated Lebanese FMF patients, had their DNA typed using sequence-specific primer (SSP) technique for the presence of 16 KIR gene and pseudogene loci, and compared them to the general Lebanese population. The AA1 genotype was the most frequent in both the FMF and control groups. Six new KIR profiles were identified. The FMF group showed a higher prevalence of KIR 3DP1*003 (p < 0.05) and an increase in the BB genotype compared with controls. The results lead to an interesting future research question of whether or not KIR genotype is involved in the predisposition to or pathogenesis of FMF. This is the first report that describes the KIR genotypic profile in this important clinical disease. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_a919993e425faa158dbc129b6a75f3f8 |
| identifier_str_mv | 1945-0265 Mahfouz, R. A., Sabbagh, A. S., Shamseddine, W., Bazarbachi, A., Ibrahim, G., Arayssi, T., ... & Khalaf, R. A. (2009). Distribution of Killer Cell Immunoglobulin–like Receptor (KIR) Genotypes in Patients with Familial Mediterranean Fever. Genetic testing and molecular biomarkers, 13(1), 91-95. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/3356 |
| publishDate | 2009 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Distribution of Killer Cell Immunoglobulin–like Receptor (KIR) Genotypes in Patients with Familial Mediterranean FeverKhazen, GeorgesKhalaf, Roy A.Mahfouz, Rami A.R.Sabbagh, Amira S.Shamseddine, WaelBazarbachi, AliGenotypic profiles of the natural killer cell immunoglobulin–like receptors (KIR) have been reported to vary among different ethnic groups and variable clinical entities. This study represents the first report on its distribution among patients with familial Mediterranean fever (FMF). We studied 56 unrelated Lebanese FMF patients, had their DNA typed using sequence-specific primer (SSP) technique for the presence of 16 KIR gene and pseudogene loci, and compared them to the general Lebanese population. The AA1 genotype was the most frequent in both the FMF and control groups. Six new KIR profiles were identified. The FMF group showed a higher prevalence of KIR 3DP1*003 (p < 0.05) and an increase in the BB genotype compared with controls. The results lead to an interesting future research question of whether or not KIR genotype is involved in the predisposition to or pathogenesis of FMF. This is the first report that describes the KIR genotypic profile in this important clinical disease.PublishedN/A2016-03-17T13:17:00Z2016-03-17T13:17:00Z20092016-03-17Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1945-0265http://hdl.handle.net/10725/3356http://dx.doi.org/10.1089/gtmb.2008.0081Mahfouz, R. A., Sabbagh, A. S., Shamseddine, W., Bazarbachi, A., Ibrahim, G., Arayssi, T., ... & Khalaf, R. A. (2009). Distribution of Killer Cell Immunoglobulin–like Receptor (KIR) Genotypes in Patients with Familial Mediterranean Fever. Genetic testing and molecular biomarkers, 13(1), 91-95.http://online.liebertpub.com/doi/pdf/10.1089/gtmb.2008.0081enGenetic Testing and Molecular Biomarkersinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/33562017-02-20T09:28:22Z |
| spellingShingle | Distribution of Killer Cell Immunoglobulin–like Receptor (KIR) Genotypes in Patients with Familial Mediterranean Fever Khazen, Georges |
| status_str | publishedVersion |
| title | Distribution of Killer Cell Immunoglobulin–like Receptor (KIR) Genotypes in Patients with Familial Mediterranean Fever |
| title_full | Distribution of Killer Cell Immunoglobulin–like Receptor (KIR) Genotypes in Patients with Familial Mediterranean Fever |
| title_fullStr | Distribution of Killer Cell Immunoglobulin–like Receptor (KIR) Genotypes in Patients with Familial Mediterranean Fever |
| title_full_unstemmed | Distribution of Killer Cell Immunoglobulin–like Receptor (KIR) Genotypes in Patients with Familial Mediterranean Fever |
| title_short | Distribution of Killer Cell Immunoglobulin–like Receptor (KIR) Genotypes in Patients with Familial Mediterranean Fever |
| title_sort | Distribution of Killer Cell Immunoglobulin–like Receptor (KIR) Genotypes in Patients with Familial Mediterranean Fever |
| url | http://hdl.handle.net/10725/3356 http://dx.doi.org/10.1089/gtmb.2008.0081 http://online.liebertpub.com/doi/pdf/10.1089/gtmb.2008.0081 |