Selective photothermolysis to target sebaceous glands
Background and Objectives The success of permanent laser hair removal suggests that selective photothermolysis (SP) of sebaceous glands, another part of hair follicles, may also have merit. About 30% of sebum consists of fats with copious CH2 bond content. SP was studied in vitro, using free electro...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , , , , |
| التنسيق: | article |
| منشور في: |
2012
|
| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/6563 http://dx.doi.org/10.1002/lsm.21132 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://onlinelibrary.wiley.com/doi/10.1002/lsm.21132/full |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513480244068352 |
|---|---|
| author | Tannous, Zeina |
| author2 | Sakamoto, Fernanda H. Doukas, Apostolos G. Farinelli, William A. Williams, Gwyn P. Anderson, Rox R. Dylla, Frederick H. Gubeli III, Joseph F. |
| author2_role | author author author author author author author |
| author_facet | Tannous, Zeina Sakamoto, Fernanda H. Doukas, Apostolos G. Farinelli, William A. Williams, Gwyn P. Anderson, Rox R. Dylla, Frederick H. Gubeli III, Joseph F. |
| author_role | author |
| dc.creator.none.fl_str_mv | Tannous, Zeina Sakamoto, Fernanda H. Doukas, Apostolos G. Farinelli, William A. Williams, Gwyn P. Anderson, Rox R. Dylla, Frederick H. Gubeli III, Joseph F. |
| dc.date.none.fl_str_mv | 2012 2017-11-08T13:07:47Z 2017-11-08T13:07:47Z 2017-11-08 |
| dc.identifier.none.fl_str_mv | 1096-9101 http://hdl.handle.net/10725/6563 http://dx.doi.org/10.1002/lsm.21132 Sakamoto, F. H., Doukas, A. G., Farinelli, W. A., Tannous, Z., Shinn, M., Benson, S., ... & Anderson, R. (2012). Selective photothermolysis to target sebaceous glands: theoretical estimation of parameters and preliminary results using a free electron laser. Lasers in surgery and medicine, 44(2), 175-183. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://onlinelibrary.wiley.com/doi/10.1002/lsm.21132/full |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Lasers in Surgery and Medicine |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Selective photothermolysis to target sebaceous glands theoretical estimation of parameters and preliminary results using a free electron laser |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Background and Objectives The success of permanent laser hair removal suggests that selective photothermolysis (SP) of sebaceous glands, another part of hair follicles, may also have merit. About 30% of sebum consists of fats with copious CH2 bond content. SP was studied in vitro, using free electron laser (FEL) pulses at an infrared CH2 vibrational absorption wavelength band. Methods Absorption spectra of natural and artificially prepared sebum were measured from 200 to 3,000 nm, to determine wavelengths potentially able to target sebaceous glands. The Jefferson National Accelerator superconducting FEL was used to measure photothermal excitation of aqueous gels, artificial sebum, pig skin, human scalp, and forehead skin (sebaceous sites). In vitro skin samples were exposed to FEL pulses from 1,620 to 1,720 nm, spot diameter 7–9.5 mm with exposure through a cold 4°C sapphire window in contact with the skin. Exposed and control tissue samples were stained using H&E, and nitroblue tetrazolium chloride staining (NBTC) was used to detect thermal denaturation. Results Natural and artificial sebum both had absorption peaks near 1,210, 1,728, 1,760, 2,306 and 2,346 nm. Laser-induced heating of artificial sebum was approximately twice that of water at 1,710 and 1,720 nm, and about 1.5× higher in human sebaceous glands than in water. Thermal camera imaging showed transient focal heating near sebaceous hair follicles. Histologically, skin samples exposed to ∼1,700 nm, ∼100–125 milliseconds pulses showed evidence of selective thermal damage to sebaceous glands. Sebaceous glands were positive for NBTC staining, without evidence of selective loss in samples exposed to the laser. Epidermis was undamaged in all samples. Conclusions SP of sebaceous glands appears to be feasible. Potentially, optical pulses at ∼1,720 or ∼1,210 nm delivered with large beam diameter and appropriate skin cooling in approximately 0.1 seconds may provide an alternative treatment for acne. Lasers Surg. Med. 44:175–183, 2012. © 2012 Wiley Periodicals, Inc. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_aa164bf868d7e8de8067df824aa5c4ad |
| identifier_str_mv | 1096-9101 Sakamoto, F. H., Doukas, A. G., Farinelli, W. A., Tannous, Z., Shinn, M., Benson, S., ... & Anderson, R. (2012). Selective photothermolysis to target sebaceous glands: theoretical estimation of parameters and preliminary results using a free electron laser. Lasers in surgery and medicine, 44(2), 175-183. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/6563 |
| publishDate | 2012 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Selective photothermolysis to target sebaceous glandstheoretical estimation of parameters and preliminary results using a free electron laserTannous, ZeinaSakamoto, Fernanda H.Doukas, Apostolos G.Farinelli, William A.Williams, Gwyn P.Anderson, Rox R.Dylla, Frederick H.Gubeli III, Joseph F.Background and Objectives The success of permanent laser hair removal suggests that selective photothermolysis (SP) of sebaceous glands, another part of hair follicles, may also have merit. About 30% of sebum consists of fats with copious CH2 bond content. SP was studied in vitro, using free electron laser (FEL) pulses at an infrared CH2 vibrational absorption wavelength band. Methods Absorption spectra of natural and artificially prepared sebum were measured from 200 to 3,000 nm, to determine wavelengths potentially able to target sebaceous glands. The Jefferson National Accelerator superconducting FEL was used to measure photothermal excitation of aqueous gels, artificial sebum, pig skin, human scalp, and forehead skin (sebaceous sites). In vitro skin samples were exposed to FEL pulses from 1,620 to 1,720 nm, spot diameter 7–9.5 mm with exposure through a cold 4°C sapphire window in contact with the skin. Exposed and control tissue samples were stained using H&E, and nitroblue tetrazolium chloride staining (NBTC) was used to detect thermal denaturation. Results Natural and artificial sebum both had absorption peaks near 1,210, 1,728, 1,760, 2,306 and 2,346 nm. Laser-induced heating of artificial sebum was approximately twice that of water at 1,710 and 1,720 nm, and about 1.5× higher in human sebaceous glands than in water. Thermal camera imaging showed transient focal heating near sebaceous hair follicles. Histologically, skin samples exposed to ∼1,700 nm, ∼100–125 milliseconds pulses showed evidence of selective thermal damage to sebaceous glands. Sebaceous glands were positive for NBTC staining, without evidence of selective loss in samples exposed to the laser. Epidermis was undamaged in all samples. Conclusions SP of sebaceous glands appears to be feasible. Potentially, optical pulses at ∼1,720 or ∼1,210 nm delivered with large beam diameter and appropriate skin cooling in approximately 0.1 seconds may provide an alternative treatment for acne. Lasers Surg. Med. 44:175–183, 2012. © 2012 Wiley Periodicals, Inc.PublishedN/A2017-11-08T13:07:47Z2017-11-08T13:07:47Z20122017-11-08Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1096-9101http://hdl.handle.net/10725/6563http://dx.doi.org/10.1002/lsm.21132Sakamoto, F. H., Doukas, A. G., Farinelli, W. A., Tannous, Z., Shinn, M., Benson, S., ... & Anderson, R. (2012). Selective photothermolysis to target sebaceous glands: theoretical estimation of parameters and preliminary results using a free electron laser. Lasers in surgery and medicine, 44(2), 175-183.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttp://onlinelibrary.wiley.com/doi/10.1002/lsm.21132/fullenLasers in Surgery and Medicineinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/65632021-03-19T10:03:27Z |
| spellingShingle | Selective photothermolysis to target sebaceous glands Tannous, Zeina |
| status_str | publishedVersion |
| title | Selective photothermolysis to target sebaceous glands |
| title_full | Selective photothermolysis to target sebaceous glands |
| title_fullStr | Selective photothermolysis to target sebaceous glands |
| title_full_unstemmed | Selective photothermolysis to target sebaceous glands |
| title_short | Selective photothermolysis to target sebaceous glands |
| title_sort | Selective photothermolysis to target sebaceous glands |
| url | http://hdl.handle.net/10725/6563 http://dx.doi.org/10.1002/lsm.21132 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://onlinelibrary.wiley.com/doi/10.1002/lsm.21132/full |