Characterization of brain lesions using MRI/spectroscopy versus FDG PET fused with MRI
Objectives: To retrospectively compare the diagnostic value of MRI with integrative spectroscopy (MRI/spec), to anatomically fused FDG PET/MRI (PET/MRI) in brain lesions. Methods: Twenty-four patients (n= 27 brain lesions) underwent MRI/spec (LX 1.5T, GE; Achieva 3.0T, Philips) and standard FDG PET/...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , |
| التنسيق: | article |
| منشور في: |
2008
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/6448 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://jnm.snmjournals.org/content/49/supplement_1/223P.2.short |
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| الملخص: | Objectives: To retrospectively compare the diagnostic value of MRI with integrative spectroscopy (MRI/spec), to anatomically fused FDG PET/MRI (PET/MRI) in brain lesions. Methods: Twenty-four patients (n= 27 brain lesions) underwent MRI/spec (LX 1.5T, GE; Achieva 3.0T, Philips) and standard FDG PET/CT including the brain (Gemini or GeminiTF, Philips) within a 3-month period. Transaxial MRI and PET images of the brain were fused using Extended Brilliance workstation (Philips). Histopathology or imaging follow-up served as reference standard. Group A (21 lesions): metastatic lesions or grade III/IV primary brain tumors; group B (6 lesions): grade I/II primary brain tumors or non-tumor lesions. PET criteria: Increased uptake in the center or periphery of the lesion was group A, otherwise group B. MRI/spec criteria: based on prior reading in reports. Results: MRI/spec and PET/MRI characterized 20/27 (74%) and 23/27 (85%) lesions correctly, and 5/27 (19%) and 4/27 (15%) lesions incorrectly. Findings of combined MRI/spec and PET/MRI are summarized in a table. Conclusions: Due to its detailed anatomical information, MRI/spec is better than PET/MRI in detecting and characterizing lesions < 2 cm. However, PET/MRI appears to characterize lesions > 2 cm better than MRI/spec because of the high specificity of FDG PET for high-grade tumors. PET/MRI can have added value in lesions that are being interpreted as indeterminate by MRI/spec. |
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