Palladin regulation of the actin structures needed for cancer invasion
Cell migration and invasion involve the formation of cell adhesion structures as well as the dynamic and spatial regulation of the cytoskeleton. The adhesive structures known as podosomes and invadopodia share a common role in cell motility, adhesion, and invasion, and form when the plasma membrane...
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| Format: | article |
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2014
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| Online Access: | http://hdl.handle.net/10725/2826 http://dx.doi.org/10.4161/cam.28024 http://www.tandfonline.com/doi/abs/10.4161/cam.28024#.V5r5hLh97cs |
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| _version_ | 1864513459440320512 |
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| author | Najm, Paul |
| author2 | El-Sibai, Mirvat |
| author2_role | author |
| author_facet | Najm, Paul El-Sibai, Mirvat |
| author_role | author |
| dc.creator.none.fl_str_mv | Najm, Paul El-Sibai, Mirvat |
| dc.date.none.fl_str_mv | 2014 2015-12-17T13:31:14Z 2015-12-17T13:31:14Z 2015-12-17 |
| dc.identifier.none.fl_str_mv | 1933-6918 http://hdl.handle.net/10725/2826 http://dx.doi.org/10.4161/cam.28024 Najm, P., & El-Sibai, M. (2014). Palladin regulation of the actin structures needed for cancer invasion. Cell adhesion & migration, 8(1), 29-35. http://www.tandfonline.com/doi/abs/10.4161/cam.28024#.V5r5hLh97cs |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Cell Adhesion & Migration |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Palladin regulation of the actin structures needed for cancer invasion |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Cell migration and invasion involve the formation of cell adhesion structures as well as the dynamic and spatial regulation of the cytoskeleton. The adhesive structures known as podosomes and invadopodia share a common role in cell motility, adhesion, and invasion, and form when the plasma membrane of motile cells undergoes highly regulated protrusions. Palladin, a molecular scaffold, co-localizes with actin-rich structures where it plays a role in their assembly and maintenance in a wide variety of cell lines. Palladin regulates actin cytoskeleton organization as well as cell adhesion formation. Moreover, palladin contributes to the invasive nature of cancer metastatic cells by regulating invadopodia formation. Palladin seems to regulate podosome and invodopodia formation through Rho GTPases, which are known as key players in coordinating the cellular responses required for cell migration and metastasis. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_ab2fe39cc86aaee140ac09cded080ea4 |
| identifier_str_mv | 1933-6918 Najm, P., & El-Sibai, M. (2014). Palladin regulation of the actin structures needed for cancer invasion. Cell adhesion & migration, 8(1), 29-35. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/2826 |
| publishDate | 2014 |
| repository.mail.fl_str_mv | |
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| spelling | Palladin regulation of the actin structures needed for cancer invasionNajm, PaulEl-Sibai, MirvatCell migration and invasion involve the formation of cell adhesion structures as well as the dynamic and spatial regulation of the cytoskeleton. The adhesive structures known as podosomes and invadopodia share a common role in cell motility, adhesion, and invasion, and form when the plasma membrane of motile cells undergoes highly regulated protrusions. Palladin, a molecular scaffold, co-localizes with actin-rich structures where it plays a role in their assembly and maintenance in a wide variety of cell lines. Palladin regulates actin cytoskeleton organization as well as cell adhesion formation. Moreover, palladin contributes to the invasive nature of cancer metastatic cells by regulating invadopodia formation. Palladin seems to regulate podosome and invodopodia formation through Rho GTPases, which are known as key players in coordinating the cellular responses required for cell migration and metastasis.PublishedN/A2015-12-17T13:31:14Z2015-12-17T13:31:14Z20142015-12-17Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1933-6918http://hdl.handle.net/10725/2826http://dx.doi.org/10.4161/cam.28024Najm, P., & El-Sibai, M. (2014). Palladin regulation of the actin structures needed for cancer invasion. Cell adhesion & migration, 8(1), 29-35.http://www.tandfonline.com/doi/abs/10.4161/cam.28024#.V5r5hLh97csenCell Adhesion & Migrationinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/28262026-02-19T07:35:53Z |
| spellingShingle | Palladin regulation of the actin structures needed for cancer invasion Najm, Paul |
| status_str | publishedVersion |
| title | Palladin regulation of the actin structures needed for cancer invasion |
| title_full | Palladin regulation of the actin structures needed for cancer invasion |
| title_fullStr | Palladin regulation of the actin structures needed for cancer invasion |
| title_full_unstemmed | Palladin regulation of the actin structures needed for cancer invasion |
| title_short | Palladin regulation of the actin structures needed for cancer invasion |
| title_sort | Palladin regulation of the actin structures needed for cancer invasion |
| url | http://hdl.handle.net/10725/2826 http://dx.doi.org/10.4161/cam.28024 http://www.tandfonline.com/doi/abs/10.4161/cam.28024#.V5r5hLh97cs |