Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease risk
Background Elevated levels of total plasma homocysteine are a risk factor for atherosclerotic disease. Aims The rationale behind this study is to explore the correlation between degree and site of coronary lesion and hyperhomocysteinemia in Lebanese CAD patients and assess environmental and genetic...
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| مؤلفون آخرون: | , , , , , , , , , , |
| التنسيق: | article |
| منشور في: |
2012
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/4504 http://dx.doi.org/10.1016/j.atherosclerosis.2012.02.035 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.sciencedirect.com/science/article/pii/S0021915012001499 |
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| _version_ | 1864513463696490496 |
|---|---|
| author | Milane, Aline |
| author2 | Platt, Daniel E. Ghassibe-Sabbagh, Michella Youhanna, Sonia Abchee, Antoine B. Haber, Marc Badro, Danielle A. Salloum, Angelique K. Douayhi, Bouchra Nemr, Rita Cazier, Jean-Baptiste Zalloua, Pierre A. |
| author2_role | author author author author author author author author author author author |
| author_facet | Milane, Aline Platt, Daniel E. Ghassibe-Sabbagh, Michella Youhanna, Sonia Abchee, Antoine B. Haber, Marc Badro, Danielle A. Salloum, Angelique K. Douayhi, Bouchra Nemr, Rita Cazier, Jean-Baptiste Zalloua, Pierre A. |
| author_role | author |
| dc.creator.none.fl_str_mv | Milane, Aline Platt, Daniel E. Ghassibe-Sabbagh, Michella Youhanna, Sonia Abchee, Antoine B. Haber, Marc Badro, Danielle A. Salloum, Angelique K. Douayhi, Bouchra Nemr, Rita Cazier, Jean-Baptiste Zalloua, Pierre A. |
| dc.date.none.fl_str_mv | 2012 2016-10-05T06:48:42Z 2016-10-05T06:48:42Z 2016-10-05 |
| dc.identifier.none.fl_str_mv | 0021-9150 http://hdl.handle.net/10725/4504 http://dx.doi.org/10.1016/j.atherosclerosis.2012.02.035 Ghassibe-Sabbagh, M., Platt, D. E., Youhanna, S., Abchee, A. B., Stewart, K., Badro, D. A., ... & Othman, R. (2012). Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease risk. Atherosclerosis, 222(1), 180-186. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.sciencedirect.com/science/article/pii/S0021915012001499 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Atherosclerosis |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease risk |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Background Elevated levels of total plasma homocysteine are a risk factor for atherosclerotic disease. Aims The rationale behind this study is to explore the correlation between degree and site of coronary lesion and hyperhomocysteinemia in Lebanese CAD patients and assess environmental and genetic factors for elevated levels of total plasma homocysteine. Methods A total of 2644 patients were analyzed for traditional CAD risk factors. Logistic regression was performed to determine the association of hyperhomocysteinemia with degree and site of coronary lesions controlling for risk factors. Environmental and genetic factors for hyperhomocysteinemia were analyzed by logistic regression using a candidate gene approach. Results Traditional risk factors were correlated with stenosis. Hyperhomocysteinemia associated with increased risk of overall stenosis, and risk of mild and severe occlusion in major arteries. Hyperhomocysteinemia and hypertension were highly correlated suggesting that hyperhomocysteinemia acts as a hypertensive agent leading to CAD. Diuretics and genetic polymorphisms in MTHFR and SLCO1B1 were associated with hyperhomocysteinemia. Conclusions Hyperhomocysteinemia is a medical indicator of specific vessel stenosis in the Lebanese population. Hypertension is a major link between hyperhomocysteinemia and CAD occurrence. Genetic polymorphisms and diuretics’ intake explain partly elevated homocysteine levels. This study has important implications in CAD risk prediction. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_b025c3e8f96fabb54bf15ea3da38554c |
| identifier_str_mv | 0021-9150 Ghassibe-Sabbagh, M., Platt, D. E., Youhanna, S., Abchee, A. B., Stewart, K., Badro, D. A., ... & Othman, R. (2012). Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease risk. Atherosclerosis, 222(1), 180-186. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/4504 |
| publishDate | 2012 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease riskMilane, AlinePlatt, Daniel E.Ghassibe-Sabbagh, MichellaYouhanna, SoniaAbchee, Antoine B.Haber, MarcBadro, Danielle A.Salloum, Angelique K.Douayhi, BouchraNemr, RitaCazier, Jean-BaptisteZalloua, Pierre A.Background Elevated levels of total plasma homocysteine are a risk factor for atherosclerotic disease. Aims The rationale behind this study is to explore the correlation between degree and site of coronary lesion and hyperhomocysteinemia in Lebanese CAD patients and assess environmental and genetic factors for elevated levels of total plasma homocysteine. Methods A total of 2644 patients were analyzed for traditional CAD risk factors. Logistic regression was performed to determine the association of hyperhomocysteinemia with degree and site of coronary lesions controlling for risk factors. Environmental and genetic factors for hyperhomocysteinemia were analyzed by logistic regression using a candidate gene approach. Results Traditional risk factors were correlated with stenosis. Hyperhomocysteinemia associated with increased risk of overall stenosis, and risk of mild and severe occlusion in major arteries. Hyperhomocysteinemia and hypertension were highly correlated suggesting that hyperhomocysteinemia acts as a hypertensive agent leading to CAD. Diuretics and genetic polymorphisms in MTHFR and SLCO1B1 were associated with hyperhomocysteinemia. Conclusions Hyperhomocysteinemia is a medical indicator of specific vessel stenosis in the Lebanese population. Hypertension is a major link between hyperhomocysteinemia and CAD occurrence. Genetic polymorphisms and diuretics’ intake explain partly elevated homocysteine levels. This study has important implications in CAD risk prediction.PublishedN/A2016-10-05T06:48:42Z2016-10-05T06:48:42Z20122016-10-05Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0021-9150http://hdl.handle.net/10725/4504http://dx.doi.org/10.1016/j.atherosclerosis.2012.02.035Ghassibe-Sabbagh, M., Platt, D. E., Youhanna, S., Abchee, A. B., Stewart, K., Badro, D. A., ... & Othman, R. (2012). Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease risk. Atherosclerosis, 222(1), 180-186.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttp://www.sciencedirect.com/science/article/pii/S0021915012001499enAtherosclerosisinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/45042021-03-19T10:03:21Z |
| spellingShingle | Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease risk Milane, Aline |
| status_str | publishedVersion |
| title | Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease risk |
| title_full | Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease risk |
| title_fullStr | Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease risk |
| title_full_unstemmed | Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease risk |
| title_short | Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease risk |
| title_sort | Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease risk |
| url | http://hdl.handle.net/10725/4504 http://dx.doi.org/10.1016/j.atherosclerosis.2012.02.035 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.sciencedirect.com/science/article/pii/S0021915012001499 |