Intravitreal tissue plasminogen activator in the management of central retinal vein occlusion
Purpose To evaluate the role of intravitreal tissue plasminogen activator (tPA) in the management of central retinal vein occlusion (CRVO) in patients with symptoms for <3 days. Methods We evaluated the visual outcome of a consecutive series of patients with CRVO following intravitreal tPA inject...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , |
| التنسيق: | article |
| منشور في: |
2003
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/10797 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://oce.ovid.com/article/00006982-200312000-00006/HTML |
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إضافة وسم
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| _version_ | 1864513487453028352 |
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| author | Ghazi, Nicola |
| author2 | Boureddine, Baha' Haddad, Randa S. Jurdi, Fadi A. Bashshur, Ziad F. |
| author2_role | author author author author |
| author_facet | Ghazi, Nicola Boureddine, Baha' Haddad, Randa S. Jurdi, Fadi A. Bashshur, Ziad F. |
| author_role | author |
| dc.creator.none.fl_str_mv | Ghazi, Nicola Boureddine, Baha' Haddad, Randa S. Jurdi, Fadi A. Bashshur, Ziad F. |
| dc.date.none.fl_str_mv | 2003 2019-06-13T09:30:01Z 2019-06-13T09:30:01Z 2019-06-13 |
| dc.identifier.none.fl_str_mv | 1539-2864 http://hdl.handle.net/10725/10797 Ghazi, N. G., BAHA’N, N. O. U. R. E. D. D. I. N. E., Haddad, R. S., Jurdi, F. A., & Bashshur, Z. F. (2003). Intravitreal tissue plasminogen activator in the management of central retinal vein occlusion. Retina, 23(6), 780-784. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://oce.ovid.com/article/00006982-200312000-00006/HTML |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Retina |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Intravitreal tissue plasminogen activator in the management of central retinal vein occlusion |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Purpose To evaluate the role of intravitreal tissue plasminogen activator (tPA) in the management of central retinal vein occlusion (CRVO) in patients with symptoms for <3 days. Methods We evaluated the visual outcome of a consecutive series of patients with CRVO following intravitreal tPA injection. All patients presented with visual acuity worse than 20/50 within 3 days from the onset of symptoms. Main outcome measures included percentage of patients whose final vision improved to 20/50 or better and change in percentage of patients with vision of 20/200 or worse before and after treatment. Results Twelve patients received intravitreal tPA for CRVO. Nine patients (75%) had best-corrected visual acuity of 20/200 or worse at presentation compared with 4 patients (33%) at the last follow-up after treatment. Five (55%) of these 9 patients had final visual acuity that improved to 20/50 or better. The remaining four patients did not have improvement or their vision continued to worsen. All 4 patients had fluorescein angiographic evidence of >10 disk areas of capillary nonperfusion at presentation. Overall, 8 (67%) of 12 patients had final visual acuity of 20/50 or better. No side effects related to tPA injection were observed. Conclusion Our data suggest that intravitreal tPA injection may have a beneficial role in the management of CRVO when used within a few days of the onset of symptoms in patients with no angiographic evidence of severe capillary nonperfusion even if initial visual acuity is 20/200 or worse. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_b53df9fe3db13f0d73a090cecebcb469 |
| identifier_str_mv | 1539-2864 Ghazi, N. G., BAHA’N, N. O. U. R. E. D. D. I. N. E., Haddad, R. S., Jurdi, F. A., & Bashshur, Z. F. (2003). Intravitreal tissue plasminogen activator in the management of central retinal vein occlusion. Retina, 23(6), 780-784. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/10797 |
| publishDate | 2003 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Intravitreal tissue plasminogen activator in the management of central retinal vein occlusionGhazi, NicolaBoureddine, Baha'Haddad, Randa S.Jurdi, Fadi A.Bashshur, Ziad F.Purpose To evaluate the role of intravitreal tissue plasminogen activator (tPA) in the management of central retinal vein occlusion (CRVO) in patients with symptoms for <3 days. Methods We evaluated the visual outcome of a consecutive series of patients with CRVO following intravitreal tPA injection. All patients presented with visual acuity worse than 20/50 within 3 days from the onset of symptoms. Main outcome measures included percentage of patients whose final vision improved to 20/50 or better and change in percentage of patients with vision of 20/200 or worse before and after treatment. Results Twelve patients received intravitreal tPA for CRVO. Nine patients (75%) had best-corrected visual acuity of 20/200 or worse at presentation compared with 4 patients (33%) at the last follow-up after treatment. Five (55%) of these 9 patients had final visual acuity that improved to 20/50 or better. The remaining four patients did not have improvement or their vision continued to worsen. All 4 patients had fluorescein angiographic evidence of >10 disk areas of capillary nonperfusion at presentation. Overall, 8 (67%) of 12 patients had final visual acuity of 20/50 or better. No side effects related to tPA injection were observed. Conclusion Our data suggest that intravitreal tPA injection may have a beneficial role in the management of CRVO when used within a few days of the onset of symptoms in patients with no angiographic evidence of severe capillary nonperfusion even if initial visual acuity is 20/200 or worse.PublishedN/A2019-06-13T09:30:01Z2019-06-13T09:30:01Z20032019-06-13Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1539-2864http://hdl.handle.net/10725/10797Ghazi, N. G., BAHA’N, N. O. U. R. E. D. D. I. N. E., Haddad, R. S., Jurdi, F. A., & Bashshur, Z. F. (2003). Intravitreal tissue plasminogen activator in the management of central retinal vein occlusion. Retina, 23(6), 780-784.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://oce.ovid.com/article/00006982-200312000-00006/HTMLenRetinainfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/107972021-03-19T10:45:17Z |
| spellingShingle | Intravitreal tissue plasminogen activator in the management of central retinal vein occlusion Ghazi, Nicola |
| status_str | publishedVersion |
| title | Intravitreal tissue plasminogen activator in the management of central retinal vein occlusion |
| title_full | Intravitreal tissue plasminogen activator in the management of central retinal vein occlusion |
| title_fullStr | Intravitreal tissue plasminogen activator in the management of central retinal vein occlusion |
| title_full_unstemmed | Intravitreal tissue plasminogen activator in the management of central retinal vein occlusion |
| title_short | Intravitreal tissue plasminogen activator in the management of central retinal vein occlusion |
| title_sort | Intravitreal tissue plasminogen activator in the management of central retinal vein occlusion |
| url | http://hdl.handle.net/10725/10797 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://oce.ovid.com/article/00006982-200312000-00006/HTML |