Reconstruction and simulation of neocortical microcircuitry
We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat. The reconstruction uses cellular and synaptic organizing principles to algorithmically reconstruct detailed anatomy and physiology from sparse experimental data. An objective anatomical met...
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2015
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| Online Access: | http://hdl.handle.net/10725/5545 http://doi.org/10.1016/j.cell.2015.09.029 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.sciencedirect.com/science/article/pii/S0092867415011915 |
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| _version_ | 1864513477344755712 |
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| author | Khazen, Georges |
| author2 | Markram, Henry Muller, Eilif Ramaswamy, Srikanth Reimann, Michael W. Abdellah, Marwan Sanchez, Carlos Aguado |
| author2_role | author author author author author author |
| author_facet | Khazen, Georges Markram, Henry Muller, Eilif Ramaswamy, Srikanth Reimann, Michael W. Abdellah, Marwan Sanchez, Carlos Aguado |
| author_role | author |
| dc.creator.none.fl_str_mv | Khazen, Georges Markram, Henry Muller, Eilif Ramaswamy, Srikanth Reimann, Michael W. Abdellah, Marwan Sanchez, Carlos Aguado |
| dc.date.none.fl_str_mv | 2015 2017-04-25T10:15:22Z 2017-04-25T10:15:22Z 2017-04-25 |
| dc.identifier.none.fl_str_mv | 1097-4172 http://hdl.handle.net/10725/5545 http://doi.org/10.1016/j.cell.2015.09.029 Markram, H., Muller, E., Ramaswamy, S., Reimann, M. W., Abdellah, M., Sanchez, C. A., ... & Kahou, G. A. A. (2015). Reconstruction and simulation of neocortical microcircuitry. Cell, 163(2), 456-492. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.sciencedirect.com/science/article/pii/S0092867415011915 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Cell |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Reconstruction and simulation of neocortical microcircuitry |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat. The reconstruction uses cellular and synaptic organizing principles to algorithmically reconstruct detailed anatomy and physiology from sparse experimental data. An objective anatomical method defines a neocortical volume of 0.29 ± 0.01 mm3 containing ∼31,000 neurons, and patch-clamp studies identify 55 layer-specific morphological and 207 morpho-electrical neuron subtypes. When digitally reconstructed neurons are positioned in the volume and synapse formation is restricted to biological bouton densities and numbers of synapses per connection, their overlapping arbors form ∼8 million connections with ∼37 million synapses. Simulations reproduce an array of in vitro and in vivo experiments without parameter tuning. Additionally, we find a spectrum of network states with a sharp transition from synchronous to asynchronous activity, modulated by physiological mechanisms. The spectrum of network states, dynamically reconfigured around this transition, supports diverse information processing strategies. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_b8e991a8a8c441e7f54bf833d8498301 |
| identifier_str_mv | 1097-4172 Markram, H., Muller, E., Ramaswamy, S., Reimann, M. W., Abdellah, M., Sanchez, C. A., ... & Kahou, G. A. A. (2015). Reconstruction and simulation of neocortical microcircuitry. Cell, 163(2), 456-492. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/5545 |
| publishDate | 2015 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Reconstruction and simulation of neocortical microcircuitryKhazen, GeorgesMarkram, HenryMuller, EilifRamaswamy, SrikanthReimann, Michael W.Abdellah, MarwanSanchez, Carlos AguadoWe present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat. The reconstruction uses cellular and synaptic organizing principles to algorithmically reconstruct detailed anatomy and physiology from sparse experimental data. An objective anatomical method defines a neocortical volume of 0.29 ± 0.01 mm3 containing ∼31,000 neurons, and patch-clamp studies identify 55 layer-specific morphological and 207 morpho-electrical neuron subtypes. When digitally reconstructed neurons are positioned in the volume and synapse formation is restricted to biological bouton densities and numbers of synapses per connection, their overlapping arbors form ∼8 million connections with ∼37 million synapses. Simulations reproduce an array of in vitro and in vivo experiments without parameter tuning. Additionally, we find a spectrum of network states with a sharp transition from synchronous to asynchronous activity, modulated by physiological mechanisms. The spectrum of network states, dynamically reconfigured around this transition, supports diverse information processing strategies.PublishedN/A2017-04-25T10:15:22Z2017-04-25T10:15:22Z20152017-04-25Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1097-4172http://hdl.handle.net/10725/5545http://doi.org/10.1016/j.cell.2015.09.029Markram, H., Muller, E., Ramaswamy, S., Reimann, M. W., Abdellah, M., Sanchez, C. A., ... & Kahou, G. A. A. (2015). Reconstruction and simulation of neocortical microcircuitry. Cell, 163(2), 456-492.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttp://www.sciencedirect.com/science/article/pii/S0092867415011915enCellinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/55452021-03-19T10:00:48Z |
| spellingShingle | Reconstruction and simulation of neocortical microcircuitry Khazen, Georges |
| status_str | publishedVersion |
| title | Reconstruction and simulation of neocortical microcircuitry |
| title_full | Reconstruction and simulation of neocortical microcircuitry |
| title_fullStr | Reconstruction and simulation of neocortical microcircuitry |
| title_full_unstemmed | Reconstruction and simulation of neocortical microcircuitry |
| title_short | Reconstruction and simulation of neocortical microcircuitry |
| title_sort | Reconstruction and simulation of neocortical microcircuitry |
| url | http://hdl.handle.net/10725/5545 http://doi.org/10.1016/j.cell.2015.09.029 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.sciencedirect.com/science/article/pii/S0092867415011915 |