StarD13 is a tumor suppressor in breast cancer that regulates cell motility and invasion
Breast cancer is one of the most commonly diagnosed cancers in women around the world. In general, the more aggressive the tumor, the more rapidly it grows and the more likely it metastasizes. Members of the Rho subfamily of small GTP-binding proteins (GTPases) play a central role in breast cancer c...
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| Format: | article |
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2014
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| Online Access: | http://hdl.handle.net/10725/2848 http://dx.doi.org/10.3892/ijo.2014.2330 https://www.spandidos-publications.com/ijo/44/5/1499 |
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| _version_ | 1864513459448709120 |
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| author | Hanna, Samer |
| author2 | Khalil, Bassem Nasrallah, Anita Saykali, Bechara A. Sobh, Rania Nasser, Selim El-Sibai, Mirvat |
| author2_role | author author author author author author |
| author_facet | Hanna, Samer Khalil, Bassem Nasrallah, Anita Saykali, Bechara A. Sobh, Rania Nasser, Selim El-Sibai, Mirvat |
| author_role | author |
| dc.creator.none.fl_str_mv | Hanna, Samer Khalil, Bassem Nasrallah, Anita Saykali, Bechara A. Sobh, Rania Nasser, Selim El-Sibai, Mirvat |
| dc.date.none.fl_str_mv | 2014 2015-12-18T07:30:44Z 2015-12-18T07:30:44Z 2015-12-18 |
| dc.identifier.none.fl_str_mv | 1019-6439 http://hdl.handle.net/10725/2848 http://dx.doi.org/10.3892/ijo.2014.2330 Hanna, S., Khalil, B., Nasrallah, A., Saykali, B. A., Sobh, R., Nasser, S., & El-Sibai, M. (2014). StarD13 is a tumor suppressor in breast cancer that regulates cell motility and invasion. International journal of oncology, 44(5), 1499-1511. https://www.spandidos-publications.com/ijo/44/5/1499 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | International Journal of Oncology |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | StarD13 is a tumor suppressor in breast cancer that regulates cell motility and invasion |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Breast cancer is one of the most commonly diagnosed cancers in women around the world. In general, the more aggressive the tumor, the more rapidly it grows and the more likely it metastasizes. Members of the Rho subfamily of small GTP-binding proteins (GTPases) play a central role in breast cancer cell motility and metastasis. The switch between active GTP-bound and inactive GDP-bound state is regulated by guanine nucleotide exchange factors (GEFs), GTPase-activating proteins (GAPs) and guanine-nucleotide dissociation inhibitors (GDIs). We studied the role of StarD13, a recently identified Rho-GAP that specifically inhibits the function of RhoA and Cdc42. We aimed to investigate its role in breast cancer proliferation and metastasis. The levels of expression of this Rho-GAP in tumor tissues of different grades were assayed using immunohistochemistry. We observed that, while the level of StarD13 expression decreases in cancer tissues compared to normal tissues, it increases as the grade of the tumor increased. This was consistent with the fact that although StarD13 was indeed a tumor suppressor in our breast cancer cells, as seen by its effect on cell proliferation, it was needed for cancer cell motility. In fact, StarD13 knockdown resulted in an inhibition of cell motility and cells were not able to detach their tail and move forward. Our study describes, for the first time, a tumor suppressor that plays a positive role in cancer motility. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_ba66dd5dbf83f4d59d39ebcb4f9beb1f |
| identifier_str_mv | 1019-6439 Hanna, S., Khalil, B., Nasrallah, A., Saykali, B. A., Sobh, R., Nasser, S., & El-Sibai, M. (2014). StarD13 is a tumor suppressor in breast cancer that regulates cell motility and invasion. International journal of oncology, 44(5), 1499-1511. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/2848 |
| publishDate | 2014 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | StarD13 is a tumor suppressor in breast cancer that regulates cell motility and invasionHanna, SamerKhalil, BassemNasrallah, AnitaSaykali, Bechara A.Sobh, RaniaNasser, SelimEl-Sibai, MirvatBreast cancer is one of the most commonly diagnosed cancers in women around the world. In general, the more aggressive the tumor, the more rapidly it grows and the more likely it metastasizes. Members of the Rho subfamily of small GTP-binding proteins (GTPases) play a central role in breast cancer cell motility and metastasis. The switch between active GTP-bound and inactive GDP-bound state is regulated by guanine nucleotide exchange factors (GEFs), GTPase-activating proteins (GAPs) and guanine-nucleotide dissociation inhibitors (GDIs). We studied the role of StarD13, a recently identified Rho-GAP that specifically inhibits the function of RhoA and Cdc42. We aimed to investigate its role in breast cancer proliferation and metastasis. The levels of expression of this Rho-GAP in tumor tissues of different grades were assayed using immunohistochemistry. We observed that, while the level of StarD13 expression decreases in cancer tissues compared to normal tissues, it increases as the grade of the tumor increased. This was consistent with the fact that although StarD13 was indeed a tumor suppressor in our breast cancer cells, as seen by its effect on cell proliferation, it was needed for cancer cell motility. In fact, StarD13 knockdown resulted in an inhibition of cell motility and cells were not able to detach their tail and move forward. Our study describes, for the first time, a tumor suppressor that plays a positive role in cancer motility.PublishedN/A2015-12-18T07:30:44Z2015-12-18T07:30:44Z20142015-12-18Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1019-6439http://hdl.handle.net/10725/2848http://dx.doi.org/10.3892/ijo.2014.2330Hanna, S., Khalil, B., Nasrallah, A., Saykali, B. A., Sobh, R., Nasser, S., & El-Sibai, M. (2014). StarD13 is a tumor suppressor in breast cancer that regulates cell motility and invasion. International journal of oncology, 44(5), 1499-1511.https://www.spandidos-publications.com/ijo/44/5/1499enInternational Journal of Oncologyinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/28482020-05-11T20:16:34Z |
| spellingShingle | StarD13 is a tumor suppressor in breast cancer that regulates cell motility and invasion Hanna, Samer |
| status_str | publishedVersion |
| title | StarD13 is a tumor suppressor in breast cancer that regulates cell motility and invasion |
| title_full | StarD13 is a tumor suppressor in breast cancer that regulates cell motility and invasion |
| title_fullStr | StarD13 is a tumor suppressor in breast cancer that regulates cell motility and invasion |
| title_full_unstemmed | StarD13 is a tumor suppressor in breast cancer that regulates cell motility and invasion |
| title_short | StarD13 is a tumor suppressor in breast cancer that regulates cell motility and invasion |
| title_sort | StarD13 is a tumor suppressor in breast cancer that regulates cell motility and invasion |
| url | http://hdl.handle.net/10725/2848 http://dx.doi.org/10.3892/ijo.2014.2330 https://www.spandidos-publications.com/ijo/44/5/1499 |