Predictive factors of recurrence in patients with pathological complete response after esophagectomy following neoadjuvant chemoradiotherapy for esophageal cancer
Background Minimal data have previously emerged from studies regarding the factors associated with recurrence in patients with ypT0N0M0 status. The purpose of the study was to predict survival and recurrence in patients with pathological complete response (pCR) following chemoradiotherapy (CRT) and...
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| مؤلفون آخرون: | , , , , , , , |
| التنسيق: | article |
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2015
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/14211 https://doi.org/10.1245/s10434-015-4619-8 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://link.springer.com/article/10.1245/s10434-015-4619-8 |
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| _version_ | 1864513469197320192 |
|---|---|
| author | Luc, Guillaume |
| author2 | Gronnier, Caroline Lebreton, Gil Brigand, Cecile Mabrut, Jean-Yves Bail, Jean-Pierre Bernard, Meunier Collet, Denis Mariette, Christophe |
| author2_role | author author author author author author author author |
| author_facet | Luc, Guillaume Gronnier, Caroline Lebreton, Gil Brigand, Cecile Mabrut, Jean-Yves Bail, Jean-Pierre Bernard, Meunier Collet, Denis Mariette, Christophe |
| author_role | author |
| dc.contributor.none.fl_str_mv | Chemaly, Rodrigue |
| dc.creator.none.fl_str_mv | Luc, Guillaume Gronnier, Caroline Lebreton, Gil Brigand, Cecile Mabrut, Jean-Yves Bail, Jean-Pierre Bernard, Meunier Collet, Denis Mariette, Christophe |
| dc.date.none.fl_str_mv | 2015 2022-11-03T13:58:48Z 2022-11-03T13:58:48Z 2022-11-03 |
| dc.identifier.none.fl_str_mv | 1068-9265 http://hdl.handle.net/10725/14211 https://doi.org/10.1245/s10434-015-4619-8 Luc, G., Gronnier, C., Lebreton, G., Brigand, C., Mabrut, J. Y., Bail, J. P., ... & Mariette, C. (2015). Predictive factors of recurrence in patients with pathological complete response after esophagectomy following neoadjuvant chemoradiotherapy for esophageal cancer: a multicenter study. Annals of surgical oncology, 22(3), 1357-1364. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://link.springer.com/article/10.1245/s10434-015-4619-8 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Annals of Surgical Oncology |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Predictive factors of recurrence in patients with pathological complete response after esophagectomy following neoadjuvant chemoradiotherapy for esophageal cancer a multicenter study |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Background Minimal data have previously emerged from studies regarding the factors associated with recurrence in patients with ypT0N0M0 status. The purpose of the study was to predict survival and recurrence in patients with pathological complete response (pCR) following chemoradiotherapy (CRT) and surgery for esophageal cancer (EC). Methods Among 2944 consecutive patients with EC operations in 30 centers between 2000 and 2010, patients treated with neoadjuvant CRT followed by surgery who achieved pCR (n = 191) were analyzed. The factors associated with survival and recurrence were analyzed using a Cox proportional hazard regression analysis. Results Among 593 patients who underwent neoadjuvant CRT followed by esophagectomy, pCR was observed in 191 patients (32.2 %). Recurrence occurred in 56 (29.3 %) patients. The median time to recurrence was 12 months. The factors associated with recurrence were postoperative complications grade 3–4 [odds ratio (OR): 2.100; 95 % confidence interval (CI) 1.008–4.366; p = 0.048) and adenocarcinoma histologic subtype (OR 2.008; 95 % CI 0.1.06–0.3.80; p = 0.032). The median overall survival was 63 months (95 % CI 39.3–87.1), and the median disease-free survival was 48 months (95 % CI 18.3–77.4). Age (>65 years) [hazard ratio (HR): 2.166; 95 % CI 1.170–4.010; p = 0.014), postoperative complications grades 3–4 [HR 2.099; 95 % CI 1.137–3.878; p = 0.018], and radiation dose (<40 Gy) (HR 0.361; 95 % CI 0.159–0.820; p = 0.015) were identified as factors associated with survival. Conclusions An intensive follow-up may be beneficial for patients with EC who achieve pCR and who develop major postoperative complications or the adenocarcinoma histologic subtype. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_bacf52cb4e096fbf9af0352e18463d53 |
| identifier_str_mv | 1068-9265 Luc, G., Gronnier, C., Lebreton, G., Brigand, C., Mabrut, J. Y., Bail, J. P., ... & Mariette, C. (2015). Predictive factors of recurrence in patients with pathological complete response after esophagectomy following neoadjuvant chemoradiotherapy for esophageal cancer: a multicenter study. Annals of surgical oncology, 22(3), 1357-1364. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/14211 |
| publishDate | 2015 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Predictive factors of recurrence in patients with pathological complete response after esophagectomy following neoadjuvant chemoradiotherapy for esophageal cancera multicenter studyLuc, GuillaumeGronnier, CarolineLebreton, GilBrigand, CecileMabrut, Jean-YvesBail, Jean-PierreBernard, MeunierCollet, DenisMariette, ChristopheBackground Minimal data have previously emerged from studies regarding the factors associated with recurrence in patients with ypT0N0M0 status. The purpose of the study was to predict survival and recurrence in patients with pathological complete response (pCR) following chemoradiotherapy (CRT) and surgery for esophageal cancer (EC). Methods Among 2944 consecutive patients with EC operations in 30 centers between 2000 and 2010, patients treated with neoadjuvant CRT followed by surgery who achieved pCR (n = 191) were analyzed. The factors associated with survival and recurrence were analyzed using a Cox proportional hazard regression analysis. Results Among 593 patients who underwent neoadjuvant CRT followed by esophagectomy, pCR was observed in 191 patients (32.2 %). Recurrence occurred in 56 (29.3 %) patients. The median time to recurrence was 12 months. The factors associated with recurrence were postoperative complications grade 3–4 [odds ratio (OR): 2.100; 95 % confidence interval (CI) 1.008–4.366; p = 0.048) and adenocarcinoma histologic subtype (OR 2.008; 95 % CI 0.1.06–0.3.80; p = 0.032). The median overall survival was 63 months (95 % CI 39.3–87.1), and the median disease-free survival was 48 months (95 % CI 18.3–77.4). Age (>65 years) [hazard ratio (HR): 2.166; 95 % CI 1.170–4.010; p = 0.014), postoperative complications grades 3–4 [HR 2.099; 95 % CI 1.137–3.878; p = 0.018], and radiation dose (<40 Gy) (HR 0.361; 95 % CI 0.159–0.820; p = 0.015) were identified as factors associated with survival. Conclusions An intensive follow-up may be beneficial for patients with EC who achieve pCR and who develop major postoperative complications or the adenocarcinoma histologic subtype.PublishedChemaly, Rodrigue2022-11-03T13:58:48Z2022-11-03T13:58:48Z20152022-11-03Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1068-9265http://hdl.handle.net/10725/14211https://doi.org/10.1245/s10434-015-4619-8Luc, G., Gronnier, C., Lebreton, G., Brigand, C., Mabrut, J. Y., Bail, J. P., ... & Mariette, C. (2015). Predictive factors of recurrence in patients with pathological complete response after esophagectomy following neoadjuvant chemoradiotherapy for esophageal cancer: a multicenter study. Annals of surgical oncology, 22(3), 1357-1364.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://link.springer.com/article/10.1245/s10434-015-4619-8enAnnals of Surgical Oncologyinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/142112022-11-03T13:58:48Z |
| spellingShingle | Predictive factors of recurrence in patients with pathological complete response after esophagectomy following neoadjuvant chemoradiotherapy for esophageal cancer Luc, Guillaume |
| status_str | publishedVersion |
| title | Predictive factors of recurrence in patients with pathological complete response after esophagectomy following neoadjuvant chemoradiotherapy for esophageal cancer |
| title_full | Predictive factors of recurrence in patients with pathological complete response after esophagectomy following neoadjuvant chemoradiotherapy for esophageal cancer |
| title_fullStr | Predictive factors of recurrence in patients with pathological complete response after esophagectomy following neoadjuvant chemoradiotherapy for esophageal cancer |
| title_full_unstemmed | Predictive factors of recurrence in patients with pathological complete response after esophagectomy following neoadjuvant chemoradiotherapy for esophageal cancer |
| title_short | Predictive factors of recurrence in patients with pathological complete response after esophagectomy following neoadjuvant chemoradiotherapy for esophageal cancer |
| title_sort | Predictive factors of recurrence in patients with pathological complete response after esophagectomy following neoadjuvant chemoradiotherapy for esophageal cancer |
| url | http://hdl.handle.net/10725/14211 https://doi.org/10.1245/s10434-015-4619-8 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://link.springer.com/article/10.1245/s10434-015-4619-8 |