The distinct roles of Ras and Rac in PI 3-kinase-dependent protrusion during EGF-stimulated cell migration

The distinct roles of Ras and Rac in PI 3-kinase-dependent protrusion during EGF-stimulated cell migration

Cell migration involves the localized extension of actinrich protrusions, a process that requires Class I phosphoinositide 3-kinases (PI 3-kinases). Both Rac and Ras have been shown to regulate actin polymerization and activate PI 3-kinase. However, the coordination of Rac, Ras and PI 3-kinase activ...

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Bibliographic Details
Main Author: Yip, Shu-Chin (author)
Other Authors: El-Sibai, Mirvat (author), Coniglio, Salvatore J. (author), Mouneimne, Ghassan (author), Eddy, Robert J. (author), Drees, Beth E. (author), Neilsen, Paul O. (author), Goswami, Sumanta (author), Symons, Marc (author), Condeelis, John S. (author), Backer, Jonathan M. (author)
Format: article
Published: 2007
Online Access:http://hdl.handle.net/10725/2493
http://dx.doi.org/10.1242/jcs.005298
http://jcs.biologists.org/content/120/17/3138.short
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http://hdl.handle.net/10725/2493
http://dx.doi.org/10.1242/jcs.005298
http://jcs.biologists.org/content/120/17/3138.short

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