Association of hypertension with coronary artery disease onset in the Lebanese population
The onset of coronary artery disease (CAD) is influenced by cardiovascular risk factors that often occur in clusters and may build on one another. The objective of this study is to examine the relationship between hypertension and CAD age of onset in the Lebanese population. This retrospective analy...
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2014
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| Online Access: | http://hdl.handle.net/10725/4171 http://dx.doi.org/10.1186/2193-1801-3-533 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://springerplus.springeropen.com/articles/10.1186/2193-1801-3-533 |
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| _version_ | 1864513462943612928 |
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| author | Milane, Aline |
| author2 | Abdallah, Jad Kanbar, Roy Khazen, Georges Saad, Aline Ghassibe-Sabbagh, Michella Salloum, Angelique K. Youhanna, Sonia El Bayeh, Hamid Chammas, Elie Platt, Daniel E. Hager, Jorg Gauguier, Dominique Zalloua, Pierre |
| author2_role | author author author author author author author author author author author author author |
| author_facet | Milane, Aline Abdallah, Jad Kanbar, Roy Khazen, Georges Saad, Aline Ghassibe-Sabbagh, Michella Salloum, Angelique K. Youhanna, Sonia El Bayeh, Hamid Chammas, Elie Platt, Daniel E. Hager, Jorg Gauguier, Dominique Zalloua, Pierre |
| author_role | author |
| dc.creator.none.fl_str_mv | Milane, Aline Abdallah, Jad Kanbar, Roy Khazen, Georges Saad, Aline Ghassibe-Sabbagh, Michella Salloum, Angelique K. Youhanna, Sonia Saad, Aline El Bayeh, Hamid Chammas, Elie Platt, Daniel E. Hager, Jorg Gauguier, Dominique Zalloua, Pierre |
| dc.date.none.fl_str_mv | 2014 2016-07-19T10:40:01Z 2016-07-19T10:40:01Z 2017-04-11 |
| dc.identifier.none.fl_str_mv | 2193-1801 http://hdl.handle.net/10725/4171 http://dx.doi.org/10.1186/2193-1801-3-533 Milane, A., Abdallah, J., Kanbar, R., Khazen, G., Ghassibe-Sabbagh, M., Salloum, A. K., ... & Platt, D. E. (2014). Association of hypertension with coronary artery disease onset in the Lebanese population. SpringerPlus, 3(1), 533-539 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://springerplus.springeropen.com/articles/10.1186/2193-1801-3-533 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | SpringerPlus |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Association of hypertension with coronary artery disease onset in the Lebanese population |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | The onset of coronary artery disease (CAD) is influenced by cardiovascular risk factors that often occur in clusters and may build on one another. The objective of this study is to examine the relationship between hypertension and CAD age of onset in the Lebanese population. This retrospective analysis was performed on data extracted from Lebanese patients (n = 3,753). Logistic regression examined the association of hypertension with the age at CAD diagnosis after controlling for other traditional risk factors. The effect of antihypertensive drugs and lifestyle changes on the onset of CAD was also investigated. Results showed that hypertension is associated with late onset CAD (OR=0.656, 95% CI=0.504-0.853, p=0.001). Use of antihypertensive drugs showed a similar association with delayed CAD onset. When comparing age of onset in CAD patients with traditional risk factors such as hypertension, diabetes, hyperlipidemia, obesity, smoking and family history of CAD, the age of onset was significantly higher for patients with hypertension compared to those with any of the other risk factors studied (p < 0.001). In conclusion, hypertension and its treatment are associated with late coronary atherosclerotic manifestations in Lebanese population. This observation is currently under investigation to clarify its genetic and/or environmental mechanisms. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_bd0eaf76ae1f31d0e108bba79627a53d |
| identifier_str_mv | 2193-1801 Milane, A., Abdallah, J., Kanbar, R., Khazen, G., Ghassibe-Sabbagh, M., Salloum, A. K., ... & Platt, D. E. (2014). Association of hypertension with coronary artery disease onset in the Lebanese population. SpringerPlus, 3(1), 533-539 |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/4171 |
| publishDate | 2014 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Association of hypertension with coronary artery disease onset in the Lebanese populationMilane, AlineAbdallah, JadKanbar, RoyKhazen, GeorgesSaad, AlineGhassibe-Sabbagh, MichellaSalloum, Angelique K.Youhanna, SoniaSaad, AlineEl Bayeh, HamidChammas, EliePlatt, Daniel E.Hager, JorgGauguier, DominiqueZalloua, PierreThe onset of coronary artery disease (CAD) is influenced by cardiovascular risk factors that often occur in clusters and may build on one another. The objective of this study is to examine the relationship between hypertension and CAD age of onset in the Lebanese population. This retrospective analysis was performed on data extracted from Lebanese patients (n = 3,753). Logistic regression examined the association of hypertension with the age at CAD diagnosis after controlling for other traditional risk factors. The effect of antihypertensive drugs and lifestyle changes on the onset of CAD was also investigated. Results showed that hypertension is associated with late onset CAD (OR=0.656, 95% CI=0.504-0.853, p=0.001). Use of antihypertensive drugs showed a similar association with delayed CAD onset. When comparing age of onset in CAD patients with traditional risk factors such as hypertension, diabetes, hyperlipidemia, obesity, smoking and family history of CAD, the age of onset was significantly higher for patients with hypertension compared to those with any of the other risk factors studied (p < 0.001). In conclusion, hypertension and its treatment are associated with late coronary atherosclerotic manifestations in Lebanese population. This observation is currently under investigation to clarify its genetic and/or environmental mechanisms.PublishedN/A2016-07-19T10:40:01Z2016-07-19T10:40:01Z20142017-04-11Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2193-1801http://hdl.handle.net/10725/4171http://dx.doi.org/10.1186/2193-1801-3-533Milane, A., Abdallah, J., Kanbar, R., Khazen, G., Ghassibe-Sabbagh, M., Salloum, A. K., ... & Platt, D. E. (2014). Association of hypertension with coronary artery disease onset in the Lebanese population. SpringerPlus, 3(1), 533-539http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttp://springerplus.springeropen.com/articles/10.1186/2193-1801-3-533enSpringerPlusinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/41712021-03-19T09:59:51Z |
| spellingShingle | Association of hypertension with coronary artery disease onset in the Lebanese population Milane, Aline |
| status_str | publishedVersion |
| title | Association of hypertension with coronary artery disease onset in the Lebanese population |
| title_full | Association of hypertension with coronary artery disease onset in the Lebanese population |
| title_fullStr | Association of hypertension with coronary artery disease onset in the Lebanese population |
| title_full_unstemmed | Association of hypertension with coronary artery disease onset in the Lebanese population |
| title_short | Association of hypertension with coronary artery disease onset in the Lebanese population |
| title_sort | Association of hypertension with coronary artery disease onset in the Lebanese population |
| url | http://hdl.handle.net/10725/4171 http://dx.doi.org/10.1186/2193-1801-3-533 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://springerplus.springeropen.com/articles/10.1186/2193-1801-3-533 |