Synthesis of DNA-Sequence-Selective Hairpin Polyamide Platinum Complexes
Two DNA-sequence-selective hairpin polyamide platinum(II) complexes, containing pyrrole and imidazole heterocyclic rings, have been synthesised by different methods. A six-ring complex, selective for (A/T)GGG(A/T) DNA sequences, was made by using solid-phase synthesis, whilst an eight-ring complex,...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , |
| التنسيق: | article |
| منشور في: |
2007
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/3496 http://dx.doi.org/10.1002/chem.200601486 http://onlinelibrary.wiley.com/doi/10.1002/chem.200601486/full |
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| _version_ | 1864513461331951616 |
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| author | Taleb, Robin |
| author2 | Jaramillo, David Wheate, Nial Aldrich-Wright, Janice |
| author2_role | author author author |
| author_facet | Taleb, Robin Jaramillo, David Wheate, Nial Aldrich-Wright, Janice |
| author_role | author |
| dc.creator.none.fl_str_mv | Taleb, Robin Jaramillo, David Wheate, Nial Aldrich-Wright, Janice |
| dc.date.none.fl_str_mv | 2007 2016-04-06T05:57:47Z 2016-04-06T05:57:47Z 2016-04-06 |
| dc.identifier.none.fl_str_mv | 0947-6539 http://hdl.handle.net/10725/3496 http://dx.doi.org/10.1002/chem.200601486 Taleb, R. I., Jaramillo, D., Wheate, N. J., & Aldrich‐Wright, J. R. (2007). Synthesis of DNA‐Sequence‐Selective Hairpin Polyamide Platinum Complexes. Chemistry–A European Journal, 13(11), 3177-3186. http://onlinelibrary.wiley.com/doi/10.1002/chem.200601486/full |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Chemistry a European Journal |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Synthesis of DNA-Sequence-Selective Hairpin Polyamide Platinum Complexes |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Two DNA-sequence-selective hairpin polyamide platinum(II) complexes, containing pyrrole and imidazole heterocyclic rings, have been synthesised by different methods. A six-ring complex, selective for (A/T)GGG(A/T) DNA sequences, was made by using solid-phase synthesis, whilst an eight-ring complex, selective for (A/T)CCTG(A/T) DNA sequences, was made by utilising standard wet chemistry. Solid-phase synthesis resulted in a significantly higher yield, required less purification and is more efficient than the wet synthesis; as such, it is the preferred method for further work. The metal complexes were characterised by 1H and 195Pt NMR spectroscopy and ESI mass spectrometry. The two compounds provide a foundation for the synthesis of more complex molecules containing multiple hairpins and/or platinum groups. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_befaa33a2176c061548a564b70679fa0 |
| identifier_str_mv | 0947-6539 Taleb, R. I., Jaramillo, D., Wheate, N. J., & Aldrich‐Wright, J. R. (2007). Synthesis of DNA‐Sequence‐Selective Hairpin Polyamide Platinum Complexes. Chemistry–A European Journal, 13(11), 3177-3186. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/3496 |
| publishDate | 2007 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Synthesis of DNA-Sequence-Selective Hairpin Polyamide Platinum ComplexesTaleb, RobinJaramillo, DavidWheate, NialAldrich-Wright, JaniceTwo DNA-sequence-selective hairpin polyamide platinum(II) complexes, containing pyrrole and imidazole heterocyclic rings, have been synthesised by different methods. A six-ring complex, selective for (A/T)GGG(A/T) DNA sequences, was made by using solid-phase synthesis, whilst an eight-ring complex, selective for (A/T)CCTG(A/T) DNA sequences, was made by utilising standard wet chemistry. Solid-phase synthesis resulted in a significantly higher yield, required less purification and is more efficient than the wet synthesis; as such, it is the preferred method for further work. The metal complexes were characterised by 1H and 195Pt NMR spectroscopy and ESI mass spectrometry. The two compounds provide a foundation for the synthesis of more complex molecules containing multiple hairpins and/or platinum groups.PublishedN/A2016-04-06T05:57:47Z2016-04-06T05:57:47Z20072016-04-06Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0947-6539http://hdl.handle.net/10725/3496http://dx.doi.org/10.1002/chem.200601486Taleb, R. I., Jaramillo, D., Wheate, N. J., & Aldrich‐Wright, J. R. (2007). Synthesis of DNA‐Sequence‐Selective Hairpin Polyamide Platinum Complexes. Chemistry–A European Journal, 13(11), 3177-3186.http://onlinelibrary.wiley.com/doi/10.1002/chem.200601486/fullenChemistry a European Journalinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/34962016-08-12T09:28:59Z |
| spellingShingle | Synthesis of DNA-Sequence-Selective Hairpin Polyamide Platinum Complexes Taleb, Robin |
| status_str | publishedVersion |
| title | Synthesis of DNA-Sequence-Selective Hairpin Polyamide Platinum Complexes |
| title_full | Synthesis of DNA-Sequence-Selective Hairpin Polyamide Platinum Complexes |
| title_fullStr | Synthesis of DNA-Sequence-Selective Hairpin Polyamide Platinum Complexes |
| title_full_unstemmed | Synthesis of DNA-Sequence-Selective Hairpin Polyamide Platinum Complexes |
| title_short | Synthesis of DNA-Sequence-Selective Hairpin Polyamide Platinum Complexes |
| title_sort | Synthesis of DNA-Sequence-Selective Hairpin Polyamide Platinum Complexes |
| url | http://hdl.handle.net/10725/3496 http://dx.doi.org/10.1002/chem.200601486 http://onlinelibrary.wiley.com/doi/10.1002/chem.200601486/full |