Anti-osteoclastic effects of C-glucosidic ellagitannins mediated by actin perturbation
Actin subunits assemble into actin filaments whose dynamics and three-dimensional architectures are further regulated by a variety of cellular factors to establish the functional actin cytoskeleton. The C-glucosidic ellagitannin vescalagin and its simpler analogue vescalin, affect both the dynamics...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , , |
| التنسيق: | article |
| منشور في: |
2018
|
| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/10344 https://doi.org/10.1016/j.ejcb.2018.09.003 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.sciencedirect.com/science/article/pii/S0171933517303229 |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513486560690176 |
|---|---|
| author | Georgess, Dan |
| author2 | Spuul, Pirjo Le Clainche, Christophe Le Nihouannen, Damien Fremaux, Isabelle Dakhli, Thierry |
| author2_role | author author author author author |
| author_facet | Georgess, Dan Spuul, Pirjo Le Clainche, Christophe Le Nihouannen, Damien Fremaux, Isabelle Dakhli, Thierry |
| author_role | author |
| dc.creator.none.fl_str_mv | Georgess, Dan Spuul, Pirjo Le Clainche, Christophe Le Nihouannen, Damien Fremaux, Isabelle Dakhli, Thierry |
| dc.date.none.fl_str_mv | 2018 2019-04-04T12:15:02Z 2019-04-04T12:15:02Z 2019-04-04 |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10725/10344 https://doi.org/10.1016/j.ejcb.2018.09.003 Georgess, D., Spuul, P., Le Clainche, C., Le Nihouannen, D., Fremaux, I., Dakhli, T., ... & Génot, E. (2018). Anti-osteoclastic effects of C-glucosidic ellagitannins mediated by actin perturbation. European journal of cell biology, 97(8), 533-545. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.sciencedirect.com/science/article/pii/S0171933517303229 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | European Journal of Cell Biology |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Anti-osteoclastic effects of C-glucosidic ellagitannins mediated by actin perturbation |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Actin subunits assemble into actin filaments whose dynamics and three-dimensional architectures are further regulated by a variety of cellular factors to establish the functional actin cytoskeleton. The C-glucosidic ellagitannin vescalagin and its simpler analogue vescalin, affect both the dynamics and the ultrastructure of the actin cytoskeleton by directly binding to F-actin. Herein, we show that in vitro, the two compounds induce the formation of distinct F-actin networks characterized by different superstructures and dynamics. In living mature osteoclasts, highly specialized bone-degrading cells that constantly remodel their cytoskeleton, vescalagin and vescalin alter actin dynamics at podosomes and compromise the integrity of the podosome belt that forms the bone-degrading apparatus. Both compounds target the bone-resorbing activity at concentrations that preserve osteoclastic maturation and survival and with no detectable impact on the behaviour of bone-forming osteoblastic cells. This anti-osteoclastic activity of vescalagin and vescalin reveals the potential of targeting actin dynamics as a new therapeutic opportunity and, in this case, as a plausible approach for the local treatment of osteoporosis. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_befc8375f719bd0779bed0b88dd4dd68 |
| identifier_str_mv | Georgess, D., Spuul, P., Le Clainche, C., Le Nihouannen, D., Fremaux, I., Dakhli, T., ... & Génot, E. (2018). Anti-osteoclastic effects of C-glucosidic ellagitannins mediated by actin perturbation. European journal of cell biology, 97(8), 533-545. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/10344 |
| publishDate | 2018 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Anti-osteoclastic effects of C-glucosidic ellagitannins mediated by actin perturbationGeorgess, DanSpuul, PirjoLe Clainche, ChristopheLe Nihouannen, DamienFremaux, IsabelleDakhli, ThierryActin subunits assemble into actin filaments whose dynamics and three-dimensional architectures are further regulated by a variety of cellular factors to establish the functional actin cytoskeleton. The C-glucosidic ellagitannin vescalagin and its simpler analogue vescalin, affect both the dynamics and the ultrastructure of the actin cytoskeleton by directly binding to F-actin. Herein, we show that in vitro, the two compounds induce the formation of distinct F-actin networks characterized by different superstructures and dynamics. In living mature osteoclasts, highly specialized bone-degrading cells that constantly remodel their cytoskeleton, vescalagin and vescalin alter actin dynamics at podosomes and compromise the integrity of the podosome belt that forms the bone-degrading apparatus. Both compounds target the bone-resorbing activity at concentrations that preserve osteoclastic maturation and survival and with no detectable impact on the behaviour of bone-forming osteoblastic cells. This anti-osteoclastic activity of vescalagin and vescalin reveals the potential of targeting actin dynamics as a new therapeutic opportunity and, in this case, as a plausible approach for the local treatment of osteoporosis.PublishedN/A2019-04-04T12:15:02Z2019-04-04T12:15:02Z20182019-04-04Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10725/10344https://doi.org/10.1016/j.ejcb.2018.09.003Georgess, D., Spuul, P., Le Clainche, C., Le Nihouannen, D., Fremaux, I., Dakhli, T., ... & Génot, E. (2018). Anti-osteoclastic effects of C-glucosidic ellagitannins mediated by actin perturbation. European journal of cell biology, 97(8), 533-545.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://www.sciencedirect.com/science/article/pii/S0171933517303229enEuropean Journal of Cell Biologyinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/103442021-03-19T10:45:18Z |
| spellingShingle | Anti-osteoclastic effects of C-glucosidic ellagitannins mediated by actin perturbation Georgess, Dan |
| status_str | publishedVersion |
| title | Anti-osteoclastic effects of C-glucosidic ellagitannins mediated by actin perturbation |
| title_full | Anti-osteoclastic effects of C-glucosidic ellagitannins mediated by actin perturbation |
| title_fullStr | Anti-osteoclastic effects of C-glucosidic ellagitannins mediated by actin perturbation |
| title_full_unstemmed | Anti-osteoclastic effects of C-glucosidic ellagitannins mediated by actin perturbation |
| title_short | Anti-osteoclastic effects of C-glucosidic ellagitannins mediated by actin perturbation |
| title_sort | Anti-osteoclastic effects of C-glucosidic ellagitannins mediated by actin perturbation |
| url | http://hdl.handle.net/10725/10344 https://doi.org/10.1016/j.ejcb.2018.09.003 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.sciencedirect.com/science/article/pii/S0171933517303229 |