Penetration of aztreonam into human cerebrospinal fluid in the presence of meningeal inflammation
Cerebrospinal fluid of aztreonam were measured in 11 patients with meningeal inflammation. Two to eight hours after a single 2 gin intravenous dose, CSF aztreonam levels ranged from 0·76 to 16·6 mg/l. The mean CSF concentration in four patients with viral meningitis was 1·28 mg/l, which was lower th...
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| Other Authors: | , , , , , |
| Format: | article |
| Published: |
1985
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| Online Access: | http://hdl.handle.net/10725/5239 https://doi.org/10.1093/jac/15.5.637 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://academic.oup.com/jac/article-abstract/15/5/637/742754/Penetration-of-aztreonam-into-human-cerebrospinal |
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| Summary: | Cerebrospinal fluid of aztreonam were measured in 11 patients with meningeal inflammation. Two to eight hours after a single 2 gin intravenous dose, CSF aztreonam levels ranged from 0·76 to 16·6 mg/l. The mean CSF concentration in four patients with viral meningitis was 1·28 mg/l, which was lower than the mean con centration of 7·2 mg/l in the five with bacterial, cryptococcal or carcinomatous meningitis. Two patients with infected subdural drains were also sampled serially and had CSF levels greater than 1 mg/l between 1 and 8 h post dose. Penetration of aztreonam into the CSF in the presence of meningeal inflammation appears adequate to warrant therapeutic trials in patients infected with susceptible organisms. |
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