LYVE-1 is not restricted to the lymph vessels
Lymphatic vessel endothelial hyaluronan receptor (LYVE)-1 is thought to be restricted to lymph vessels and has been used as such to show that tumor lymphangiogenesis occurs on overexpression of lymphangiogenic factors in mouse tumor models. However, these studies have not yet been corroborated in hu...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , , , |
| التنسيق: | article |
| منشور في: |
2001
|
| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/5162 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://cancerres.aacrjournals.org/content/61/22/8079.short |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513465332269056 |
|---|---|
| author | Nasser, Selim M. |
| author2 | Carreira, Carla Mouta Di Timaso, Emmanuelle Padera, Timothy P. Boucher, Yves Tomarev, Stanislav I. Jain, Rakesh K. |
| author2_role | author author author author author author |
| author_facet | Nasser, Selim M. Carreira, Carla Mouta Di Timaso, Emmanuelle Padera, Timothy P. Boucher, Yves Tomarev, Stanislav I. Jain, Rakesh K. |
| author_role | author |
| dc.creator.none.fl_str_mv | Nasser, Selim M. Carreira, Carla Mouta Di Timaso, Emmanuelle Padera, Timothy P. Boucher, Yves Tomarev, Stanislav I. Jain, Rakesh K. |
| dc.date.none.fl_str_mv | 2001 2017-02-02T12:03:26Z 2017-02-02T12:03:26Z 2017-02-02 |
| dc.identifier.none.fl_str_mv | 0008-5472 http://hdl.handle.net/10725/5162 Carreira, C. M., Nasser, S. M., di Tomaso, E., Padera, T. P., Boucher, Y., Tomarev, S. I., & Jain, R. K. (2001). LYVE-1 is not restricted to the lymph vessels. Cancer research, 61(22), 8079-8084. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://cancerres.aacrjournals.org/content/61/22/8079.short |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Cancer Research |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | LYVE-1 is not restricted to the lymph vessels |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Lymphatic vessel endothelial hyaluronan receptor (LYVE)-1 is thought to be restricted to lymph vessels and has been used as such to show that tumor lymphangiogenesis occurs on overexpression of lymphangiogenic factors in mouse tumor models. However, these studies have not yet been corroborated in human tumors. Here we show, first, that LYVE-1 is not exclusive to the lymph vessels. Indeed, LYVE-1 is also present in normal hepatic blood sinusoidal endothelial cells in mice and humans. Surprisingly, LYVE-1 is absent from the angiogenic blood vessels of human liver tumors and only weakly present in the microcirculation of regenerative hepatic nodules in cirrhosis, though both vessels are largely derived from the liver sinusoids. Second, we propose a novel approach to identify lymphatics in human and murine liver. By combining LYVE-1 and Prox 1 (a transcription factor) immunohistochemistry, we demonstrate that lymphatics are abundant in cirrhosis. In contrast, in human hepatocellular carcinoma and liver metastases, they are restricted to the tumor margin and surrounding liver. The absence of intratumor lymphatics in hepatocellular carcinomas and liver metastases may impair molecular and cellular transport in these tumors. Finally, the presence of LYVE-1 in liver sinusoidal endothelia suggests that LYVE-1 has functions beyond the lymph vascular system. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_c0b4f31cfbbaab84207682d6982876ba |
| identifier_str_mv | 0008-5472 Carreira, C. M., Nasser, S. M., di Tomaso, E., Padera, T. P., Boucher, Y., Tomarev, S. I., & Jain, R. K. (2001). LYVE-1 is not restricted to the lymph vessels. Cancer research, 61(22), 8079-8084. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/5162 |
| publishDate | 2001 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | LYVE-1 is not restricted to the lymph vesselsNasser, Selim M.Carreira, Carla MoutaDi Timaso, EmmanuellePadera, Timothy P.Boucher, YvesTomarev, Stanislav I.Jain, Rakesh K.Lymphatic vessel endothelial hyaluronan receptor (LYVE)-1 is thought to be restricted to lymph vessels and has been used as such to show that tumor lymphangiogenesis occurs on overexpression of lymphangiogenic factors in mouse tumor models. However, these studies have not yet been corroborated in human tumors. Here we show, first, that LYVE-1 is not exclusive to the lymph vessels. Indeed, LYVE-1 is also present in normal hepatic blood sinusoidal endothelial cells in mice and humans. Surprisingly, LYVE-1 is absent from the angiogenic blood vessels of human liver tumors and only weakly present in the microcirculation of regenerative hepatic nodules in cirrhosis, though both vessels are largely derived from the liver sinusoids. Second, we propose a novel approach to identify lymphatics in human and murine liver. By combining LYVE-1 and Prox 1 (a transcription factor) immunohistochemistry, we demonstrate that lymphatics are abundant in cirrhosis. In contrast, in human hepatocellular carcinoma and liver metastases, they are restricted to the tumor margin and surrounding liver. The absence of intratumor lymphatics in hepatocellular carcinomas and liver metastases may impair molecular and cellular transport in these tumors. Finally, the presence of LYVE-1 in liver sinusoidal endothelia suggests that LYVE-1 has functions beyond the lymph vascular system.PublishedN/A2017-02-02T12:03:26Z2017-02-02T12:03:26Z20012017-02-02Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0008-5472http://hdl.handle.net/10725/5162Carreira, C. M., Nasser, S. M., di Tomaso, E., Padera, T. P., Boucher, Y., Tomarev, S. I., & Jain, R. K. (2001). LYVE-1 is not restricted to the lymph vessels. Cancer research, 61(22), 8079-8084.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttp://cancerres.aacrjournals.org/content/61/22/8079.shortenCancer Researchinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/51622021-03-19T10:00:53Z |
| spellingShingle | LYVE-1 is not restricted to the lymph vessels Nasser, Selim M. |
| status_str | publishedVersion |
| title | LYVE-1 is not restricted to the lymph vessels |
| title_full | LYVE-1 is not restricted to the lymph vessels |
| title_fullStr | LYVE-1 is not restricted to the lymph vessels |
| title_full_unstemmed | LYVE-1 is not restricted to the lymph vessels |
| title_short | LYVE-1 is not restricted to the lymph vessels |
| title_sort | LYVE-1 is not restricted to the lymph vessels |
| url | http://hdl.handle.net/10725/5162 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://cancerres.aacrjournals.org/content/61/22/8079.short |