Selective changes in cytosolic β-adrenergic cAMP signals and L-type Calcium Channel regulation by Phosphodiesterases during cardiac hypertrophy

Selective changes in cytosolic β-adrenergic cAMP signals and L-type Calcium Channel regulation by Phosphodiesterases during cardiac hypertrophy

Background In cardiomyocytes, phosphodiesterases (PDEs) type 3 and 4 are the predominant enzymes that degrade cAMP generated by β-adrenergic receptors (β-ARs), impacting notably the regulation of the L-type Ca2+ current (ICa,L). Cardiac hypertrophy (CH) is accompanied by a reduction in PDE3 and PDE4...

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Main Author: Abi-Gerges, Aniella (author)
Other Authors: Castro, Liliana (author), Leroy, Jerome (author), Domergue, Valerie (author), Fischmeister, Rodolphe (author), Vandecasteele, Gregoire (author)
Format: article
Published: 2020
Online Access:http://hdl.handle.net/10725/12315
https://doi.org/10.1016/j.yjmcc.2020.10.011
http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php
https://www.sciencedirect.com/science/article/pii/S0022282820303060
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http://hdl.handle.net/10725/12315
https://doi.org/10.1016/j.yjmcc.2020.10.011
http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php
https://www.sciencedirect.com/science/article/pii/S0022282820303060

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