Over‐expression of the p110β but not p110α isoform of PI 3‐kinase inhibits motility in breast cancer cells

Phosphoinositide 3-kinase (PI 3-kinase) activity is required for growth factor-induced cytoskeletal regulation and cell migration. We previously found that in MTLn3 rat adenocarcinoma cells, EGF-stimulated induction of actin barbed ends and lamellipod extension specifically requires the p85/p110α is...

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Bibliographic Details
Main Author: Yip, Shu-Chin (author)
Other Authors: El-Sibai, Mirvat (author), Hill, Karen M. (author), Wu, Haiyan (author), Fu, Zheng (author), Condeelis, John S. (author), Backer, Jonathan M. (author)
Format: article
Published: 2004
Online Access:http://hdl.handle.net/10725/2499
http://dx.doi.org/10.1002/cm.20032
http://onlinelibrary.wiley.com/doi/10.1002/cm.20032/abstract
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