Programming Effects of Short Prenatal Exposure to Dexamethasone in Sheep
Recent studies have linked fetal exposure to a suboptimal intrauterine environment with adult hypertension. The aims of the present study were to see whether prenatal dexamethasone administered intravenously to the ewe between 26 to 28 days of gestation (1) resulted in high blood pressure in male an...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , |
| التنسيق: | article |
| منشور في: |
2002
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/4428 http://dx.doi.org/10.1161/01.HYP.0000036455.62159.7E http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://hyper.ahajournals.org/content/40/5/729.full |
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| _version_ | 1864513463582195712 |
|---|---|
| author | Abouantoun, Tamara |
| author2 | Dodic, Miodrag O'Connor, Anne Wintour, E. Marelyn Moritz, Karen M. |
| author2_role | author author author author |
| author_facet | Abouantoun, Tamara Dodic, Miodrag O'Connor, Anne Wintour, E. Marelyn Moritz, Karen M. |
| author_role | author |
| dc.creator.none.fl_str_mv | Abouantoun, Tamara Dodic, Miodrag O'Connor, Anne Wintour, E. Marelyn Moritz, Karen M. |
| dc.date.none.fl_str_mv | 2002 2016-09-27T11:48:24Z 2016-09-27T11:48:24Z 2016-09-27 |
| dc.identifier.none.fl_str_mv | 0194-911X http://hdl.handle.net/10725/4428 http://dx.doi.org/10.1161/01.HYP.0000036455.62159.7E Dodic, M., Abouantoun, T., O’Connor, A., Wintour, E. M., & Moritz, K. M. (2002). Programming effects of short prenatal exposure to dexamethasone in sheep. Hypertension, 40(5), 729-734. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://hyper.ahajournals.org/content/40/5/729.full |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Hypertension |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Programming Effects of Short Prenatal Exposure to Dexamethasone in Sheep |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Recent studies have linked fetal exposure to a suboptimal intrauterine environment with adult hypertension. The aims of the present study were to see whether prenatal dexamethasone administered intravenously to the ewe between 26 to 28 days of gestation (1) resulted in high blood pressure in male and female offspring and whether hypertension in males was modulated by testosterone status, and (2) altered gene expression for angiotensinogen and angiotensin type 1 (AT1) receptors in the brain in late gestation and in the adult. Basal mean arterial pressure (MAP) at 2 years of age was significantly higher in wethers exposed to prenatal dexamethasone (group D; 106 5 mm Hg, n9) compared with the control group (group S; 91 3 mm Hg, n8; P0.01). Infusion of testosterone for 3 weeks had no effect on MAP in either treatment group. At 130 days of gestation, dexamethasone administered between 26 to 28 days of gestation (group DF; n8), resulted in an increased expression of angiotensinogen in hypothalamus (in arbitrary units: 2.5 0.3 versus 1.3 0.3 in the saline group [group SF], n10; P0.05). In addition, there was higher expression of the AT1 receptors in medulla oblongata in group DF (2.6 0.6 versus 1.1 0.2 in group SF; P0.01). This effect of prenatal dexamethasone treatment was still evident in females at 7 years of age (group DA; n5; 2.6 0.5 versus 1.1 0.2 in group SA; n6, P0.05). In conclusion, brief prenatal exposure of the pregnant ewe to dexamethasone leads to hypertension in adult animals of both sexes. Most interestingly, the mechanism leading to programming of hypertension might be linked with the brain angiotensin system. (Hyperte |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_c8f24fa935d1ec79defc0bd452d79a98 |
| identifier_str_mv | 0194-911X Dodic, M., Abouantoun, T., O’Connor, A., Wintour, E. M., & Moritz, K. M. (2002). Programming effects of short prenatal exposure to dexamethasone in sheep. Hypertension, 40(5), 729-734. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/4428 |
| publishDate | 2002 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Programming Effects of Short Prenatal Exposure to Dexamethasone in SheepAbouantoun, TamaraDodic, MiodragO'Connor, AnneWintour, E. MarelynMoritz, Karen M.Recent studies have linked fetal exposure to a suboptimal intrauterine environment with adult hypertension. The aims of the present study were to see whether prenatal dexamethasone administered intravenously to the ewe between 26 to 28 days of gestation (1) resulted in high blood pressure in male and female offspring and whether hypertension in males was modulated by testosterone status, and (2) altered gene expression for angiotensinogen and angiotensin type 1 (AT1) receptors in the brain in late gestation and in the adult. Basal mean arterial pressure (MAP) at 2 years of age was significantly higher in wethers exposed to prenatal dexamethasone (group D; 106 5 mm Hg, n9) compared with the control group (group S; 91 3 mm Hg, n8; P0.01). Infusion of testosterone for 3 weeks had no effect on MAP in either treatment group. At 130 days of gestation, dexamethasone administered between 26 to 28 days of gestation (group DF; n8), resulted in an increased expression of angiotensinogen in hypothalamus (in arbitrary units: 2.5 0.3 versus 1.3 0.3 in the saline group [group SF], n10; P0.05). In addition, there was higher expression of the AT1 receptors in medulla oblongata in group DF (2.6 0.6 versus 1.1 0.2 in group SF; P0.01). This effect of prenatal dexamethasone treatment was still evident in females at 7 years of age (group DA; n5; 2.6 0.5 versus 1.1 0.2 in group SA; n6, P0.05). In conclusion, brief prenatal exposure of the pregnant ewe to dexamethasone leads to hypertension in adult animals of both sexes. Most interestingly, the mechanism leading to programming of hypertension might be linked with the brain angiotensin system. (HypertePublishedN/A2016-09-27T11:48:24Z2016-09-27T11:48:24Z20022016-09-27Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0194-911Xhttp://hdl.handle.net/10725/4428http://dx.doi.org/10.1161/01.HYP.0000036455.62159.7EDodic, M., Abouantoun, T., O’Connor, A., Wintour, E. M., & Moritz, K. M. (2002). Programming effects of short prenatal exposure to dexamethasone in sheep. Hypertension, 40(5), 729-734.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttp://hyper.ahajournals.org/content/40/5/729.fullenHypertensioninfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/44282021-03-19T10:00:46Z |
| spellingShingle | Programming Effects of Short Prenatal Exposure to Dexamethasone in Sheep Abouantoun, Tamara |
| status_str | publishedVersion |
| title | Programming Effects of Short Prenatal Exposure to Dexamethasone in Sheep |
| title_full | Programming Effects of Short Prenatal Exposure to Dexamethasone in Sheep |
| title_fullStr | Programming Effects of Short Prenatal Exposure to Dexamethasone in Sheep |
| title_full_unstemmed | Programming Effects of Short Prenatal Exposure to Dexamethasone in Sheep |
| title_short | Programming Effects of Short Prenatal Exposure to Dexamethasone in Sheep |
| title_sort | Programming Effects of Short Prenatal Exposure to Dexamethasone in Sheep |
| url | http://hdl.handle.net/10725/4428 http://dx.doi.org/10.1161/01.HYP.0000036455.62159.7E http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://hyper.ahajournals.org/content/40/5/729.full |