Growth rate and rupture rate of unruptured intracranial aneurysms: a population approach
Background Understanding aneurysm growth rate allows us to predict not only the current rupture risk, but also accumulated rupture risk in the future. However, determining growth rate of unruptured intracranial aneurysms often requires follow-up of patients for a long period of time so that signific...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | |
| التنسيق: | article |
| منشور في: |
2009
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/11017 https://doi.org/10.1186/1475-925X-8-11 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://biomedical-engineering-online.biomedcentral.com/articles/10.1186/1475-925X-8-11 |
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| _version_ | 1864513487965782016 |
|---|---|
| author | Jour, Liang-Der |
| author2 | Mawad, Michel E. |
| author2_role | author |
| author_facet | Jour, Liang-Der Mawad, Michel E. |
| author_role | author |
| dc.creator.none.fl_str_mv | Jour, Liang-Der Mawad, Michel E. |
| dc.date.none.fl_str_mv | 2009 2019-07-10T05:18:05Z 2019-07-10T05:18:05Z 2019-07-10 |
| dc.identifier.none.fl_str_mv | 1475-925X http://hdl.handle.net/10725/11017 https://doi.org/10.1186/1475-925X-8-11 Jou, L. D., & Mawad, M. E. (2009). Growth rate and rupture rate of unruptured intracranial aneurysms: a population approach. Biomedical engineering online, 8(1), 11. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://biomedical-engineering-online.biomedcentral.com/articles/10.1186/1475-925X-8-11 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | BioMedical Engineering OnLine |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Growth rate and rupture rate of unruptured intracranial aneurysms: a population approach |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Background Understanding aneurysm growth rate allows us to predict not only the current rupture risk, but also accumulated rupture risk in the future. However, determining growth rate of unruptured intracranial aneurysms often requires follow-up of patients for a long period of time so that significant growth can be observed and measured. We investigate a relationship between growth rate and rupture rate and develop a theoretical model that can predict average behavior of unruptured intracranial aneurysms based on existing clinical data. Methods A mathematical model is developed that links growth rate and rupture rate. This model assumes a stable aneurysm size distribution so the number of aneurysm ruptures is balanced by the growth of aneurysms. Annual growth rates and growth profiles are calculated from a hypothetical size distribution and data from a previous clinical study. Results Our model predicts a growth rate of 0.34–1.63 mm/yr for three different growth models when the rupture rate at 10 mm is 1%. The growth rate is 0.56–0.65 mm/yr if annual rupture rate averaged over all aneurysm sizes is assumed to be 2%. The peak of aneurysm size distribution coincides with a period of slow growth between 5 mm and 8 mm. Conclusion This mathematical model can be used to predict aneurysm growth rate, and the results are consistent with previous clinical studies. Predictions from both hypothetical and clinical cases agree very well. This model explains why some aneurysms may grow into a stable size and remain so without rupture. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_c8f59bb73bfbdb2ccd9682011f991f89 |
| identifier_str_mv | 1475-925X Jou, L. D., & Mawad, M. E. (2009). Growth rate and rupture rate of unruptured intracranial aneurysms: a population approach. Biomedical engineering online, 8(1), 11. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/11017 |
| publishDate | 2009 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Growth rate and rupture rate of unruptured intracranial aneurysms: a population approachJour, Liang-DerMawad, Michel E.Background Understanding aneurysm growth rate allows us to predict not only the current rupture risk, but also accumulated rupture risk in the future. However, determining growth rate of unruptured intracranial aneurysms often requires follow-up of patients for a long period of time so that significant growth can be observed and measured. We investigate a relationship between growth rate and rupture rate and develop a theoretical model that can predict average behavior of unruptured intracranial aneurysms based on existing clinical data. Methods A mathematical model is developed that links growth rate and rupture rate. This model assumes a stable aneurysm size distribution so the number of aneurysm ruptures is balanced by the growth of aneurysms. Annual growth rates and growth profiles are calculated from a hypothetical size distribution and data from a previous clinical study. Results Our model predicts a growth rate of 0.34–1.63 mm/yr for three different growth models when the rupture rate at 10 mm is 1%. The growth rate is 0.56–0.65 mm/yr if annual rupture rate averaged over all aneurysm sizes is assumed to be 2%. The peak of aneurysm size distribution coincides with a period of slow growth between 5 mm and 8 mm. Conclusion This mathematical model can be used to predict aneurysm growth rate, and the results are consistent with previous clinical studies. Predictions from both hypothetical and clinical cases agree very well. This model explains why some aneurysms may grow into a stable size and remain so without rupture.PublishedN/A2019-07-10T05:18:05Z2019-07-10T05:18:05Z20092019-07-10Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1475-925Xhttp://hdl.handle.net/10725/11017https://doi.org/10.1186/1475-925X-8-11Jou, L. D., & Mawad, M. E. (2009). Growth rate and rupture rate of unruptured intracranial aneurysms: a population approach. Biomedical engineering online, 8(1), 11.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://biomedical-engineering-online.biomedcentral.com/articles/10.1186/1475-925X-8-11enBioMedical Engineering OnLineinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/110172021-03-19T10:45:26Z |
| spellingShingle | Growth rate and rupture rate of unruptured intracranial aneurysms: a population approach Jour, Liang-Der |
| status_str | publishedVersion |
| title | Growth rate and rupture rate of unruptured intracranial aneurysms: a population approach |
| title_full | Growth rate and rupture rate of unruptured intracranial aneurysms: a population approach |
| title_fullStr | Growth rate and rupture rate of unruptured intracranial aneurysms: a population approach |
| title_full_unstemmed | Growth rate and rupture rate of unruptured intracranial aneurysms: a population approach |
| title_short | Growth rate and rupture rate of unruptured intracranial aneurysms: a population approach |
| title_sort | Growth rate and rupture rate of unruptured intracranial aneurysms: a population approach |
| url | http://hdl.handle.net/10725/11017 https://doi.org/10.1186/1475-925X-8-11 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://biomedical-engineering-online.biomedcentral.com/articles/10.1186/1475-925X-8-11 |