Optimization of quantitative MGMT promoter methylation analysis using pyrosequencing and combined bisulfite restriction analysis

Resistance to chemotherapy is a major complication during treatment of cancer patients. Hypermethylation of the MGMT gene alters DNA repair and is associated with longer survival of glioblastoma patients treated with alkylating agents. Therefore, MGMT promoter methylation plays an important role as...

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Bibliographic Details
Main Author:	El Maarri, Osman (author)
Other Authors:	Mikeska, Thomas (author), Bock, Christoph (author), Hubner, Anika (author), Ehrentraut, Denise (author), Schramm, Johannes (author), Felsberg, Jorg (author), Khl, Philip (author), Buttner, Reinhard (author), Pietsch, Torsten (author), Waha, Andreas (author)
Format:	article
Published:	2007
Online Access:	http://hdl.handle.net/10725/6179 https://doi.org/10.2353/jmoldx.2007.060167 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.sciencedirect.com/science/article/pii/S1525157810604060
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Optimization of quantitative MGMT promoter methylation analysis using pyrosequencing and combined bisulfite restriction analysis

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