Effect of different types of smoking and synergism with hepatitis C virus on risk of hepatocellular carcinoma in American men and women
The International Agency for Research on Cancer has declared smoking to be a risk factor for hepatocellular carcinoma (HCC). However, passive exposure to cigarette smoke and use of noncigarette tobacco products on the risk of HCC has not been examined. Therefore, we evaluated the independent effects...
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2008
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| Online Access: | http://hdl.handle.net/10725/2588 http://dx.doi.org/10.1002/ijc.23730 http://onlinelibrary.wiley.com/doi/10.1002/ijc.23730/full |
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| _version_ | 1864513458670665728 |
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| author | Hassan, Manal |
| author2 | Spitz, Margaret Thomas, Melanie El-Deeb, Adel Glover, Katrina Nguyem, Nga Chan, Wenyaw Kaseb, Ahmed Curley, Steven Vauthey, Nicolas Ellis, Lee Abdalla, Eddie Lozano, Richard Patt, Yehuda Brown, Thomas Abbruzzese, James Li, Donghui |
| author2_role | author author author author author author author author author author author author author author author author |
| author_facet | Hassan, Manal Spitz, Margaret Thomas, Melanie El-Deeb, Adel Glover, Katrina Nguyem, Nga Chan, Wenyaw Kaseb, Ahmed Curley, Steven Vauthey, Nicolas Ellis, Lee Abdalla, Eddie Lozano, Richard Patt, Yehuda Brown, Thomas Abbruzzese, James Li, Donghui |
| author_role | author |
| dc.creator.none.fl_str_mv | Hassan, Manal Spitz, Margaret Thomas, Melanie El-Deeb, Adel Glover, Katrina Nguyem, Nga Chan, Wenyaw Kaseb, Ahmed Curley, Steven Vauthey, Nicolas Ellis, Lee Abdalla, Eddie Lozano, Richard Patt, Yehuda Brown, Thomas Abbruzzese, James Li, Donghui |
| dc.date.none.fl_str_mv | 2008 2015-11-17T07:23:19Z 2015-11-17T07:23:19Z 2015-11-17 |
| dc.identifier.none.fl_str_mv | 0020-7136 http://hdl.handle.net/10725/2588 http://dx.doi.org/10.1002/ijc.23730 Hassan, M. M., Spitz, M. R., Thomas, M. B., El‐Deeb, A. S., Glover, K. Y., Nguyen, N. T., ... & Li, D. (2008). Effect of different types of smoking and synergism with hepatitis C virus on risk of hepatocellular carcinoma in American men and women: Case‐control study. International Journal of Cancer, 123(8), 1883-1891. http://onlinelibrary.wiley.com/doi/10.1002/ijc.23730/full |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | International Journal of Cancer |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Effect of different types of smoking and synergism with hepatitis C virus on risk of hepatocellular carcinoma in American men and women Case-control study |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | The International Agency for Research on Cancer has declared smoking to be a risk factor for hepatocellular carcinoma (HCC). However, passive exposure to cigarette smoke and use of noncigarette tobacco products on the risk of HCC has not been examined. Therefore, we evaluated the independent effects of different types of smoking exposure along with multiple risk factors for HCC and determined whether the magnitude of smoking was modified by other risk factors in men and women. We conducted a case-control study at The University of Texas M. D. Anderson Cancer Center where 319 HCC patients and 1,061 healthy control subjects were personally interviewed for several HCC risk factors. Multivariate logistic regression analysis was performed to estimate the adjusted odds ratio (AOR) and 95% confidence interval (CI) for each potential risk factor. Use of smokeless tobacco (chewing tobacco and snuff), cigars, pipes and passive smoking exposure were not related to HCC among noncigarette smokers. However, regular cigarette smoking was associated with HCC in men: AOR, 1.9 (95% CI, 1.1–3.1). Heavy alcohol consumption was associated with HCC in women: AOR, 7.7 (95% CI, 2.3–25.1). Cigarette smoking interacted synergistically with chronic infection of hepatitis C virus in men: AOR, 136.3 (95% CI, 43.2–429.6) and with heavy alcohol consumption in women: AOR, 13.7 (95% CI, 3.2–57.9). We conclude that sex differences were observed in HCC relationship with cigarette smoking and alcohol consumption. Controlling for smoking exposure might be a prudent approach to the prevention of HCC, especially in patients with chronic viral hepatitis infections. © 2008 Wiley-Liss, Inc. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_cb2b585918ebf8d2b7b2239ed953494e |
| identifier_str_mv | 0020-7136 Hassan, M. M., Spitz, M. R., Thomas, M. B., El‐Deeb, A. S., Glover, K. Y., Nguyen, N. T., ... & Li, D. (2008). Effect of different types of smoking and synergism with hepatitis C virus on risk of hepatocellular carcinoma in American men and women: Case‐control study. International Journal of Cancer, 123(8), 1883-1891. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/2588 |
| publishDate | 2008 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Effect of different types of smoking and synergism with hepatitis C virus on risk of hepatocellular carcinoma in American men and womenCase-control studyHassan, ManalSpitz, MargaretThomas, MelanieEl-Deeb, AdelGlover, KatrinaNguyem, NgaChan, WenyawKaseb, AhmedCurley, StevenVauthey, NicolasEllis, LeeAbdalla, EddieLozano, RichardPatt, YehudaBrown, ThomasAbbruzzese, JamesLi, DonghuiThe International Agency for Research on Cancer has declared smoking to be a risk factor for hepatocellular carcinoma (HCC). However, passive exposure to cigarette smoke and use of noncigarette tobacco products on the risk of HCC has not been examined. Therefore, we evaluated the independent effects of different types of smoking exposure along with multiple risk factors for HCC and determined whether the magnitude of smoking was modified by other risk factors in men and women. We conducted a case-control study at The University of Texas M. D. Anderson Cancer Center where 319 HCC patients and 1,061 healthy control subjects were personally interviewed for several HCC risk factors. Multivariate logistic regression analysis was performed to estimate the adjusted odds ratio (AOR) and 95% confidence interval (CI) for each potential risk factor. Use of smokeless tobacco (chewing tobacco and snuff), cigars, pipes and passive smoking exposure were not related to HCC among noncigarette smokers. However, regular cigarette smoking was associated with HCC in men: AOR, 1.9 (95% CI, 1.1–3.1). Heavy alcohol consumption was associated with HCC in women: AOR, 7.7 (95% CI, 2.3–25.1). Cigarette smoking interacted synergistically with chronic infection of hepatitis C virus in men: AOR, 136.3 (95% CI, 43.2–429.6) and with heavy alcohol consumption in women: AOR, 13.7 (95% CI, 3.2–57.9). We conclude that sex differences were observed in HCC relationship with cigarette smoking and alcohol consumption. Controlling for smoking exposure might be a prudent approach to the prevention of HCC, especially in patients with chronic viral hepatitis infections. © 2008 Wiley-Liss, Inc.PublishedN/A2015-11-17T07:23:19Z2015-11-17T07:23:19Z20082015-11-17Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0020-7136http://hdl.handle.net/10725/2588http://dx.doi.org/10.1002/ijc.23730Hassan, M. M., Spitz, M. R., Thomas, M. B., El‐Deeb, A. S., Glover, K. Y., Nguyen, N. T., ... & Li, D. (2008). Effect of different types of smoking and synergism with hepatitis C virus on risk of hepatocellular carcinoma in American men and women: Case‐control study. International Journal of Cancer, 123(8), 1883-1891.http://onlinelibrary.wiley.com/doi/10.1002/ijc.23730/fullenInternational Journal of Cancerinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/25882019-02-26T08:25:49Z |
| spellingShingle | Effect of different types of smoking and synergism with hepatitis C virus on risk of hepatocellular carcinoma in American men and women Hassan, Manal |
| status_str | publishedVersion |
| title | Effect of different types of smoking and synergism with hepatitis C virus on risk of hepatocellular carcinoma in American men and women |
| title_full | Effect of different types of smoking and synergism with hepatitis C virus on risk of hepatocellular carcinoma in American men and women |
| title_fullStr | Effect of different types of smoking and synergism with hepatitis C virus on risk of hepatocellular carcinoma in American men and women |
| title_full_unstemmed | Effect of different types of smoking and synergism with hepatitis C virus on risk of hepatocellular carcinoma in American men and women |
| title_short | Effect of different types of smoking and synergism with hepatitis C virus on risk of hepatocellular carcinoma in American men and women |
| title_sort | Effect of different types of smoking and synergism with hepatitis C virus on risk of hepatocellular carcinoma in American men and women |
| url | http://hdl.handle.net/10725/2588 http://dx.doi.org/10.1002/ijc.23730 http://onlinelibrary.wiley.com/doi/10.1002/ijc.23730/full |