Is resection of colorectal liver metastases after a second-line chemotherapy regimen justified?
BACKGROUND: Patient outcomes following resection of colorectal liver metastases (CLM) after second-line chemotherapy regimen is unknown. METHODS: From August 1998 to June 2009, data from 1099 patients with CLM were collected prospectively. We retrospectively analyzed outcomes of patients who underwe...
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| مؤلفون آخرون: | , , , , , , , , , |
| التنسيق: | article |
| منشور في: |
2011
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/2628 http://dx.doi.org/10.1002/cncr.26036 http://onlinelibrary.wiley.com/doi/10.1002/cncr.26036/full |
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| _version_ | 1864513458985238528 |
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| author | Brouquet, Antoine |
| author2 | Overman, Micheal Kopetz, Scott Maru, Dipen Loyer, Evelyne Andreou, Andreas Cooper, Amanda Curley, Steven Garrett, Christopher Abdalla, Eddie Vauthey, Jean-Nicolas |
| author2_role | author author author author author author author author author author |
| author_facet | Brouquet, Antoine Overman, Micheal Kopetz, Scott Maru, Dipen Loyer, Evelyne Andreou, Andreas Cooper, Amanda Curley, Steven Garrett, Christopher Abdalla, Eddie Vauthey, Jean-Nicolas |
| author_role | author |
| dc.creator.none.fl_str_mv | Brouquet, Antoine Overman, Micheal Kopetz, Scott Maru, Dipen Loyer, Evelyne Andreou, Andreas Cooper, Amanda Curley, Steven Garrett, Christopher Abdalla, Eddie Vauthey, Jean-Nicolas |
| dc.date.none.fl_str_mv | 2011 2015-11-19T09:54:29Z 2015-11-19T09:54:29Z 2017-05-23 |
| dc.identifier.none.fl_str_mv | 0008-543X http://hdl.handle.net/10725/2628 http://dx.doi.org/10.1002/cncr.26036 Brouquet, A., Overman, M. J., Kopetz, S., Maru, D. M., Loyer, E. M., Andreou, A., ... & Vauthey, J. N. (2011). Is resection of colorectal liver metastases after a second‐line chemotherapy regimen justified?. Cancer, 117(19), 4484-4492. http://onlinelibrary.wiley.com/doi/10.1002/cncr.26036/full |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Cancer |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Is resection of colorectal liver metastases after a second-line chemotherapy regimen justified? |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | BACKGROUND: Patient outcomes following resection of colorectal liver metastases (CLM) after second-line chemotherapy regimen is unknown. METHODS: From August 1998 to June 2009, data from 1099 patients with CLM were collected prospectively. We retrospectively analyzed outcomes of patients who underwent resection of CLM after second-line (2 or more) chemotherapy regimens. RESULTS: Sixty patients underwent resection of CLM after 2 or more chemotherapy regimens. Patients had advanced CLM (mean number of CLM ± standard deviation, 4 ± 3.5; mean maximum size of CLM, 5 ± 3.2 cm) and had received 17 ± 8 cycles of preoperative chemotherapy. In 54 (90%) patients, the switch from the first regimen to another regimen was motivated by tumor progression or suboptimal radiographic response. All patients received irinotecan or oxaliplatin, and the majority (42/60 [70%]) received a monoclonal antibody (bevacizumab or cetuximab) as part of the last preoperative regimen. Postoperative morbidity and mortality rates were 33% and 3%, respectively. At a median follow-up of 32 months, 1-year, 3-year, and 5-year overall survival rates were 83%, 41%, and 22%, respectively. Median chemotherapy-free survival after resection or completion of additional chemotherapy administered after resection was 9 months (95% confidence interval, 4-14 months). Synchronous (vs metachronous) CLM and minor (vs major) pathologic response were independently associated with worse survival. CONCLUSIONS: Resection of CLM after a second-line chemotherapy regimen was found to be safe and was associated with a modest hope for definitive cure. This approach represents a viable option in patients with advanced CLM. Cancer 2011;. © 2011 American Cancer Society. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_cc6e8025099e9d7ac2b529f6063bb8a8 |
| identifier_str_mv | 0008-543X Brouquet, A., Overman, M. J., Kopetz, S., Maru, D. M., Loyer, E. M., Andreou, A., ... & Vauthey, J. N. (2011). Is resection of colorectal liver metastases after a second‐line chemotherapy regimen justified?. Cancer, 117(19), 4484-4492. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/2628 |
| publishDate | 2011 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Is resection of colorectal liver metastases after a second-line chemotherapy regimen justified?Brouquet, AntoineOverman, MichealKopetz, ScottMaru, DipenLoyer, EvelyneAndreou, AndreasCooper, AmandaCurley, StevenGarrett, ChristopherAbdalla, EddieVauthey, Jean-NicolasBACKGROUND: Patient outcomes following resection of colorectal liver metastases (CLM) after second-line chemotherapy regimen is unknown. METHODS: From August 1998 to June 2009, data from 1099 patients with CLM were collected prospectively. We retrospectively analyzed outcomes of patients who underwent resection of CLM after second-line (2 or more) chemotherapy regimens. RESULTS: Sixty patients underwent resection of CLM after 2 or more chemotherapy regimens. Patients had advanced CLM (mean number of CLM ± standard deviation, 4 ± 3.5; mean maximum size of CLM, 5 ± 3.2 cm) and had received 17 ± 8 cycles of preoperative chemotherapy. In 54 (90%) patients, the switch from the first regimen to another regimen was motivated by tumor progression or suboptimal radiographic response. All patients received irinotecan or oxaliplatin, and the majority (42/60 [70%]) received a monoclonal antibody (bevacizumab or cetuximab) as part of the last preoperative regimen. Postoperative morbidity and mortality rates were 33% and 3%, respectively. At a median follow-up of 32 months, 1-year, 3-year, and 5-year overall survival rates were 83%, 41%, and 22%, respectively. Median chemotherapy-free survival after resection or completion of additional chemotherapy administered after resection was 9 months (95% confidence interval, 4-14 months). Synchronous (vs metachronous) CLM and minor (vs major) pathologic response were independently associated with worse survival. CONCLUSIONS: Resection of CLM after a second-line chemotherapy regimen was found to be safe and was associated with a modest hope for definitive cure. This approach represents a viable option in patients with advanced CLM. Cancer 2011;. © 2011 American Cancer Society.PublishedN/A2015-11-19T09:54:29Z2015-11-19T09:54:29Z20112017-05-23Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0008-543Xhttp://hdl.handle.net/10725/2628http://dx.doi.org/10.1002/cncr.26036Brouquet, A., Overman, M. J., Kopetz, S., Maru, D. M., Loyer, E. M., Andreou, A., ... & Vauthey, J. N. (2011). Is resection of colorectal liver metastases after a second‐line chemotherapy regimen justified?. Cancer, 117(19), 4484-4492.http://onlinelibrary.wiley.com/doi/10.1002/cncr.26036/fullenCancerinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/26282021-03-19T09:59:49Z |
| spellingShingle | Is resection of colorectal liver metastases after a second-line chemotherapy regimen justified? Brouquet, Antoine |
| status_str | publishedVersion |
| title | Is resection of colorectal liver metastases after a second-line chemotherapy regimen justified? |
| title_full | Is resection of colorectal liver metastases after a second-line chemotherapy regimen justified? |
| title_fullStr | Is resection of colorectal liver metastases after a second-line chemotherapy regimen justified? |
| title_full_unstemmed | Is resection of colorectal liver metastases after a second-line chemotherapy regimen justified? |
| title_short | Is resection of colorectal liver metastases after a second-line chemotherapy regimen justified? |
| title_sort | Is resection of colorectal liver metastases after a second-line chemotherapy regimen justified? |
| url | http://hdl.handle.net/10725/2628 http://dx.doi.org/10.1002/cncr.26036 http://onlinelibrary.wiley.com/doi/10.1002/cncr.26036/full |