Outcome of home parenteral nutrition in 251 children over a 14-y period
Background: Parenteral nutrition (PN) is the main treatment for intestinal failure. Objective: We aimed to review the indications for home parenteral nutrition (HPN) in children and describe the outcome over a 14-y period from a single center. Design: We conducted a retrospective study that included...
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2016
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| Online Access: | http://hdl.handle.net/10725/3995 http://dx.doi.org/10.3945/ajcn.115.121756 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://ajcn.nutrition.org/content/103/5/1327.short |
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| author | Abi Nader, Elie |
| author2 | Lambe, Cecile Talbotec, Cecile Pigneur, Benedicte Lacaille, Florence Garnier-Lengline, Helene |
| author2_role | author author author author author |
| author_facet | Abi Nader, Elie Lambe, Cecile Talbotec, Cecile Pigneur, Benedicte Lacaille, Florence Garnier-Lengline, Helene |
| author_role | author |
| dc.creator.none.fl_str_mv | Abi Nader, Elie Lambe, Cecile Talbotec, Cecile Pigneur, Benedicte Lacaille, Florence Garnier-Lengline, Helene |
| dc.date.none.fl_str_mv | 2016-06-09T09:23:01Z 2016-06-09T09:23:01Z 2016 2016-06-09 |
| dc.identifier.none.fl_str_mv | 0002-9165 http://hdl.handle.net/10725/3995 http://dx.doi.org/10.3945/ajcn.115.121756 Nader, E. A., Lambe, C., Talbotec, C., Pigneur, B., Lacaille, F., Garnier-Lengliné, H., ... & Aigrain, Y. (2016). Outcome of home parenteral nutrition in 251 children over a 14-y period: report of a single center. The American journal of clinical nutrition, 103(5), 1327-1336. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://ajcn.nutrition.org/content/103/5/1327.short |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | The American Journal of Clinical Nutrition |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Outcome of home parenteral nutrition in 251 children over a 14-y period report of a single center |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Background: Parenteral nutrition (PN) is the main treatment for intestinal failure. Objective: We aimed to review the indications for home parenteral nutrition (HPN) in children and describe the outcome over a 14-y period from a single center. Design: We conducted a retrospective study that included all children who were referred to our institution and discharged while receiving HPN between 1 January 2000 and 31 December 2013. The indications for HPN were divided into primary digestive diseases (PDDs) and primary nondigestive diseases (PNDDs). We compared our results to a previous study that was performed in our unit from 1980 to 2000 and included 302 patients. Results: A total of 251 patients were included: 217 (86%) had a PDD. The mean ± SD age at HPN onset was 0.7 ± 0.3 y, with a mean duration of 1.9 ± 0.4 y. The indications for HPN were short bowel syndrome (SBS) (59%), PNDD (14%), congenital enteropathies (10%), chronic intestinal pseudo-obstruction syndromes (9%), inflammatory bowel diseases (5%), and other digestive diseases (3%). By 31 December 2013, 52% of children were weaned off of HPN, 9% of the PDD subgroup had intestinal transplantation, and 10% died mostly because of immune deficiency. The major complications of HPN were catheter-related bloodstream infections (CRBSIs) (1.7/1000 d of PN) and intestinal failure-associated liver disease (IFALD) (51 children; 20% of cohort). An increased rate of CRBSIs was observed compared with our previous study, but we saw a decreasing trend since 2012. No noteworthy deceleration of growth was observed in SBS children 6 mo after weaning off HPN. Conclusions: SBS was the major indication for HPN in our cohort. IFALD and CRBSIs were potentially life-threatening problems. Nevertheless, complication rates were low, and deaths resulted mostly from the underlying disease. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_d037fd2b2c1c2f2305194f0b39f0765f |
| identifier_str_mv | 0002-9165 Nader, E. A., Lambe, C., Talbotec, C., Pigneur, B., Lacaille, F., Garnier-Lengliné, H., ... & Aigrain, Y. (2016). Outcome of home parenteral nutrition in 251 children over a 14-y period: report of a single center. The American journal of clinical nutrition, 103(5), 1327-1336. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/3995 |
| publishDate | 2016 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
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| spelling | Outcome of home parenteral nutrition in 251 children over a 14-y periodreport of a single centerAbi Nader, ElieLambe, CecileTalbotec, CecilePigneur, BenedicteLacaille, FlorenceGarnier-Lengline, HeleneBackground: Parenteral nutrition (PN) is the main treatment for intestinal failure. Objective: We aimed to review the indications for home parenteral nutrition (HPN) in children and describe the outcome over a 14-y period from a single center. Design: We conducted a retrospective study that included all children who were referred to our institution and discharged while receiving HPN between 1 January 2000 and 31 December 2013. The indications for HPN were divided into primary digestive diseases (PDDs) and primary nondigestive diseases (PNDDs). We compared our results to a previous study that was performed in our unit from 1980 to 2000 and included 302 patients. Results: A total of 251 patients were included: 217 (86%) had a PDD. The mean ± SD age at HPN onset was 0.7 ± 0.3 y, with a mean duration of 1.9 ± 0.4 y. The indications for HPN were short bowel syndrome (SBS) (59%), PNDD (14%), congenital enteropathies (10%), chronic intestinal pseudo-obstruction syndromes (9%), inflammatory bowel diseases (5%), and other digestive diseases (3%). By 31 December 2013, 52% of children were weaned off of HPN, 9% of the PDD subgroup had intestinal transplantation, and 10% died mostly because of immune deficiency. The major complications of HPN were catheter-related bloodstream infections (CRBSIs) (1.7/1000 d of PN) and intestinal failure-associated liver disease (IFALD) (51 children; 20% of cohort). An increased rate of CRBSIs was observed compared with our previous study, but we saw a decreasing trend since 2012. No noteworthy deceleration of growth was observed in SBS children 6 mo after weaning off HPN. Conclusions: SBS was the major indication for HPN in our cohort. IFALD and CRBSIs were potentially life-threatening problems. Nevertheless, complication rates were low, and deaths resulted mostly from the underlying disease.PublishedN/A2016-06-09T09:23:01Z2016-06-09T09:23:01Z20162016-06-09Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0002-9165http://hdl.handle.net/10725/3995http://dx.doi.org/10.3945/ajcn.115.121756Nader, E. A., Lambe, C., Talbotec, C., Pigneur, B., Lacaille, F., Garnier-Lengliné, H., ... & Aigrain, Y. (2016). Outcome of home parenteral nutrition in 251 children over a 14-y period: report of a single center. The American journal of clinical nutrition, 103(5), 1327-1336.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttp://ajcn.nutrition.org/content/103/5/1327.shortenThe American Journal of Clinical Nutritioninfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/39952021-03-19T10:00:50Z |
| spellingShingle | Outcome of home parenteral nutrition in 251 children over a 14-y period Abi Nader, Elie |
| status_str | publishedVersion |
| title | Outcome of home parenteral nutrition in 251 children over a 14-y period |
| title_full | Outcome of home parenteral nutrition in 251 children over a 14-y period |
| title_fullStr | Outcome of home parenteral nutrition in 251 children over a 14-y period |
| title_full_unstemmed | Outcome of home parenteral nutrition in 251 children over a 14-y period |
| title_short | Outcome of home parenteral nutrition in 251 children over a 14-y period |
| title_sort | Outcome of home parenteral nutrition in 251 children over a 14-y period |
| url | http://hdl.handle.net/10725/3995 http://dx.doi.org/10.3945/ajcn.115.121756 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://ajcn.nutrition.org/content/103/5/1327.short |