Effect of consanguinity on birth weight for gestational age in a developing country
Consanguinity, the marriage between relatives, has been associated with adverse child health outcomes because it increases homozygosity of recessive alleles. The objective of this study was to assess the effect of consanguinity on the birth weight of newborns in Greater Beirut, Lebanon. Cross-sectio...
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2007
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| Online Access: | http://hdl.handle.net/10725/9894 https://doi.org/10.1093/aje/kwk108 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://academic.oup.com/aje/article/165/7/742/158945 |
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| _version_ | 1864513485738606592 |
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| author | Wakim, Gerard |
| author2 | Mumtaz, Ghina Tamim, Hala Kanaan, Mona Khawaja, Marwan Khogali, Mustafa |
| author2_role | author author author author author |
| author_facet | Wakim, Gerard Mumtaz, Ghina Tamim, Hala Kanaan, Mona Khawaja, Marwan Khogali, Mustafa |
| author_role | author |
| dc.creator.none.fl_str_mv | Wakim, Gerard Mumtaz, Ghina Tamim, Hala Kanaan, Mona Khawaja, Marwan Khogali, Mustafa |
| dc.date.none.fl_str_mv | 2007 2018-12-20T11:05:09Z 2018-12-20T11:05:09Z 2018-12-20 |
| dc.identifier.none.fl_str_mv | 1476-6256 http://hdl.handle.net/10725/9894 https://doi.org/10.1093/aje/kwk108 Mumtaz, G., Tamim, H., Kanaan, M., Khawaja, M., Khogali, M., Wakim, G., & Yunis, K. A. (2007). Effect of consanguinity on birth weight for gestational age in a developing country. American journal of epidemiology, 165(7), 742-752. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://academic.oup.com/aje/article/165/7/742/158945 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | American Journal of Epidemiology |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Effect of consanguinity on birth weight for gestational age in a developing country |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Consanguinity, the marriage between relatives, has been associated with adverse child health outcomes because it increases homozygosity of recessive alleles. The objective of this study was to assess the effect of consanguinity on the birth weight of newborns in Greater Beirut, Lebanon. Cross-sectional data were collected on 10,289 consecutive liveborn singleton newborns admitted to eight hospitals belonging to the National Collaborative Perinatal Neonatal Network during the years 2000 and 2001. Birth weight was modeled by use of the fetal growth ratio, defined as the ratio of the observed birth weight to the median birth weight for gestational age. A mixed-effect multiple linear regression model was used to predict the net effect of first- and second-cousin marriage on the birth weight for gestational age, accounting for within-hospital clustering of data. After controlling for medical and sociodemographic covariates, the authors found a statistically significant negative association between consanguinity and birth weight at each gestational age. No significant difference was observed in the decrease in birth weight between the first- and second-cousin marriages. Overall, consanguinity was associated with a decrease in birth weight for gestational age by 1.8% (ß = −0.018, 95% confidence interval: −0.027, −0.008). The largest effects on fetal growth were seen with lower parity and smoking during pregnancy. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_d0db787d4173e02fa63aaa96e212828d |
| identifier_str_mv | 1476-6256 Mumtaz, G., Tamim, H., Kanaan, M., Khawaja, M., Khogali, M., Wakim, G., & Yunis, K. A. (2007). Effect of consanguinity on birth weight for gestational age in a developing country. American journal of epidemiology, 165(7), 742-752. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/9894 |
| publishDate | 2007 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Effect of consanguinity on birth weight for gestational age in a developing countryWakim, GerardMumtaz, GhinaTamim, HalaKanaan, MonaKhawaja, MarwanKhogali, MustafaConsanguinity, the marriage between relatives, has been associated with adverse child health outcomes because it increases homozygosity of recessive alleles. The objective of this study was to assess the effect of consanguinity on the birth weight of newborns in Greater Beirut, Lebanon. Cross-sectional data were collected on 10,289 consecutive liveborn singleton newborns admitted to eight hospitals belonging to the National Collaborative Perinatal Neonatal Network during the years 2000 and 2001. Birth weight was modeled by use of the fetal growth ratio, defined as the ratio of the observed birth weight to the median birth weight for gestational age. A mixed-effect multiple linear regression model was used to predict the net effect of first- and second-cousin marriage on the birth weight for gestational age, accounting for within-hospital clustering of data. After controlling for medical and sociodemographic covariates, the authors found a statistically significant negative association between consanguinity and birth weight at each gestational age. No significant difference was observed in the decrease in birth weight between the first- and second-cousin marriages. Overall, consanguinity was associated with a decrease in birth weight for gestational age by 1.8% (ß = −0.018, 95% confidence interval: −0.027, −0.008). The largest effects on fetal growth were seen with lower parity and smoking during pregnancy.PublishedN/A2018-12-20T11:05:09Z2018-12-20T11:05:09Z20072018-12-20Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1476-6256http://hdl.handle.net/10725/9894https://doi.org/10.1093/aje/kwk108Mumtaz, G., Tamim, H., Kanaan, M., Khawaja, M., Khogali, M., Wakim, G., & Yunis, K. A. (2007). Effect of consanguinity on birth weight for gestational age in a developing country. American journal of epidemiology, 165(7), 742-752.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://academic.oup.com/aje/article/165/7/742/158945enAmerican Journal of Epidemiologyinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/98942021-03-19T10:45:30Z |
| spellingShingle | Effect of consanguinity on birth weight for gestational age in a developing country Wakim, Gerard |
| status_str | publishedVersion |
| title | Effect of consanguinity on birth weight for gestational age in a developing country |
| title_full | Effect of consanguinity on birth weight for gestational age in a developing country |
| title_fullStr | Effect of consanguinity on birth weight for gestational age in a developing country |
| title_full_unstemmed | Effect of consanguinity on birth weight for gestational age in a developing country |
| title_short | Effect of consanguinity on birth weight for gestational age in a developing country |
| title_sort | Effect of consanguinity on birth weight for gestational age in a developing country |
| url | http://hdl.handle.net/10725/9894 https://doi.org/10.1093/aje/kwk108 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://academic.oup.com/aje/article/165/7/742/158945 |