Cadherin-related protein 24 induces morphological changes and partial cell polarization by facilitating direct cell-cell interactions
Cadherin-related protein 24 (CDHR24) is a potential tumor suppressor located apically as well as laterally in polarized cells. Here, the role of CDHR24 in contributing to cell morphology and polarity is examined. CDHR24 was predominantly localized at the nonattached part of nonpolarizing cells while...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , |
| التنسيق: | article |
| منشور في: |
2012
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/2351 http://dx.doi.org/ 10.1515/hsz-2011-0203 http://ku7rj9xt8c.scholar.serialssolutions.com/?sid=google&auinit=M&aulast=Behrendt&atitle=Cadherin-related+protein+24+induces+morphological+changes+and+partial+cell+polarization+by+facilitating+direct+cell-cell+interactions.&id=pmid:22628312 |
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| _version_ | 1864513457952391168 |
|---|---|
| author | Rizk, Sandra |
| author2 | Behrendt, Marc Krahn, Micheal P. Al-Bayati, Hiam Amiri, Mahdi Naim, Hassan Y. |
| author2_role | author author author author author |
| author_facet | Rizk, Sandra Behrendt, Marc Krahn, Micheal P. Al-Bayati, Hiam Amiri, Mahdi Naim, Hassan Y. |
| author_role | author |
| dc.creator.none.fl_str_mv | Rizk, Sandra Behrendt, Marc Krahn, Micheal P. Al-Bayati, Hiam Amiri, Mahdi Naim, Hassan Y. |
| dc.date.none.fl_str_mv | 2012 2015-10-27T08:18:16Z 2015-10-27T08:18:16Z 2015-10-27 |
| dc.identifier.none.fl_str_mv | 1431-6730 http://hdl.handle.net/10725/2351 http://dx.doi.org/ 10.1515/hsz-2011-0203 Behrendt, M., Krahn, M. P., Al-Bayati, H., Amiri, M., Rizk, S., & Naim, H. Y. (2012). Cadherin-related protein 24 induces morphological changes and partial cell polarization by facilitating direct cell-cell interactions. http://ku7rj9xt8c.scholar.serialssolutions.com/?sid=google&auinit=M&aulast=Behrendt&atitle=Cadherin-related+protein+24+induces+morphological+changes+and+partial+cell+polarization+by+facilitating+direct+cell-cell+interactions.&id=pmid:22628312 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Biological Chemistry |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Cadherin-related protein 24 induces morphological changes and partial cell polarization by facilitating direct cell-cell interactions |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Cadherin-related protein 24 (CDHR24) is a potential tumor suppressor located apically as well as laterally in polarized cells. Here, the role of CDHR24 in contributing to cell morphology and polarity is examined. CDHR24 was predominantly localized at the nonattached part of nonpolarizing cells while another apically sorted protein, aminopeptidase N, was equally distributed over the plasma membrane. Furthermore, CDHR24 expression induced cell aggregation capacity, indicating direct cell-cell interaction. The transepithelial resistance, however, was elevated in polarized MDCK cells, but not in nonpolarizing CHO cells. Our data propose a model in which CDHR24 is directly involved in cell and tissue morphogenesis. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_d1296044764e8f5735cbd23cfd3904b2 |
| identifier_str_mv | 1431-6730 Behrendt, M., Krahn, M. P., Al-Bayati, H., Amiri, M., Rizk, S., & Naim, H. Y. (2012). Cadherin-related protein 24 induces morphological changes and partial cell polarization by facilitating direct cell-cell interactions. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/2351 |
| publishDate | 2012 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Cadherin-related protein 24 induces morphological changes and partial cell polarization by facilitating direct cell-cell interactionsRizk, SandraBehrendt, MarcKrahn, Micheal P.Al-Bayati, HiamAmiri, MahdiNaim, Hassan Y.Cadherin-related protein 24 (CDHR24) is a potential tumor suppressor located apically as well as laterally in polarized cells. Here, the role of CDHR24 in contributing to cell morphology and polarity is examined. CDHR24 was predominantly localized at the nonattached part of nonpolarizing cells while another apically sorted protein, aminopeptidase N, was equally distributed over the plasma membrane. Furthermore, CDHR24 expression induced cell aggregation capacity, indicating direct cell-cell interaction. The transepithelial resistance, however, was elevated in polarized MDCK cells, but not in nonpolarizing CHO cells. Our data propose a model in which CDHR24 is directly involved in cell and tissue morphogenesis.PublishedN/A2015-10-27T08:18:16Z2015-10-27T08:18:16Z20122015-10-27Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1431-6730http://hdl.handle.net/10725/2351http://dx.doi.org/ 10.1515/hsz-2011-0203Behrendt, M., Krahn, M. P., Al-Bayati, H., Amiri, M., Rizk, S., & Naim, H. Y. (2012). Cadherin-related protein 24 induces morphological changes and partial cell polarization by facilitating direct cell-cell interactions.http://ku7rj9xt8c.scholar.serialssolutions.com/?sid=google&auinit=M&aulast=Behrendt&atitle=Cadherin-related+protein+24+induces+morphological+changes+and+partial+cell+polarization+by+facilitating+direct+cell-cell+interactions.&id=pmid:22628312enBiological Chemistryinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/23512016-08-24T06:35:45Z |
| spellingShingle | Cadherin-related protein 24 induces morphological changes and partial cell polarization by facilitating direct cell-cell interactions Rizk, Sandra |
| status_str | publishedVersion |
| title | Cadherin-related protein 24 induces morphological changes and partial cell polarization by facilitating direct cell-cell interactions |
| title_full | Cadherin-related protein 24 induces morphological changes and partial cell polarization by facilitating direct cell-cell interactions |
| title_fullStr | Cadherin-related protein 24 induces morphological changes and partial cell polarization by facilitating direct cell-cell interactions |
| title_full_unstemmed | Cadherin-related protein 24 induces morphological changes and partial cell polarization by facilitating direct cell-cell interactions |
| title_short | Cadherin-related protein 24 induces morphological changes and partial cell polarization by facilitating direct cell-cell interactions |
| title_sort | Cadherin-related protein 24 induces morphological changes and partial cell polarization by facilitating direct cell-cell interactions |
| url | http://hdl.handle.net/10725/2351 http://dx.doi.org/ 10.1515/hsz-2011-0203 http://ku7rj9xt8c.scholar.serialssolutions.com/?sid=google&auinit=M&aulast=Behrendt&atitle=Cadherin-related+protein+24+induces+morphological+changes+and+partial+cell+polarization+by+facilitating+direct+cell-cell+interactions.&id=pmid:22628312 |