Long-term histopathologic changes in canine aneurysms embolized with Guglielmi detachable coils
PURPOSE To evaluate the long-term histologic changes, including those in the ultrastructure of the neoendothelium, occurring in experimental canine aneurysms obliterated with Guglielmi detachable coils. METHODS Ten experimental aneurysms were surgically created in mongrel dogs using side-to-side jug...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , |
| التنسيق: | article |
| منشور في: |
1995
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/10993 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.ajnr.org/content/16/1/7.short |
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| _version_ | 1864513487923838976 |
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| author | Mawad, Michel E. |
| author2 | Mawad, Janine K. Carterwright, Joiner Gokaslan, Ziya |
| author2_role | author author author |
| author_facet | Mawad, Michel E. Mawad, Janine K. Carterwright, Joiner Gokaslan, Ziya |
| author_role | author |
| dc.creator.none.fl_str_mv | Mawad, Michel E. Mawad, Janine K. Carterwright, Joiner Gokaslan, Ziya |
| dc.date.none.fl_str_mv | 1995 2019-07-08T09:41:27Z 2019-07-08T09:41:27Z 2019-07-08 |
| dc.identifier.none.fl_str_mv | 1936-959X http://hdl.handle.net/10725/10993 Mawad, M. E., Mawad, J. K., Cartwright, J., & Gokaslan, Z. (1995). Long-term histopathologic changes in canine aneurysms embolized with Guglielmi detachable coils. American journal of neuroradiology, 16(1), 7-13. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.ajnr.org/content/16/1/7.short |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | American Journal of Neuroradiology |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Long-term histopathologic changes in canine aneurysms embolized with Guglielmi detachable coils |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | PURPOSE To evaluate the long-term histologic changes, including those in the ultrastructure of the neoendothelium, occurring in experimental canine aneurysms obliterated with Guglielmi detachable coils. METHODS Ten experimental aneurysms were surgically created in mongrel dogs using side-to-side jugular carotid fistulas that were subsequently ligated to form blind pouch venous aneurysms dependent on the carotid circulation. The aneurysms were obliterated with Guglielmi detachable coils, and the animals were kept in observation. Six months after the endovascular obliteration of the aneurysms, repeat carotid arteriography was performed to assess for potential recanalization of the aneurysms. The animals were then killed and submitted for autopsy. The carotid artery and the embolized aneurysm were resected and studied with light and electron microscopy. RESULTS Both completely obliterated and recanalized aneurysms were excluded from the parent circulation by an endothelialized layer of connective tissue. The fundus of the aneurysm was completely obliterated by heavy reactive fibrous tissue surrounding the coils with very minimal, if any, inflammatory reaction. The neointima is composed of three well-identifiable layers, the most superficial of which is formed of new endothelial cells positioned next to each other in a cobblestone fashion over a basal membrane. CONCLUSION In the absence of histologic data in human aneurysms obliterated with Guglielmi detachable coils, several observations made in our experimental study help in the understanding of the long-term results expected from this endovascular technique. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_d401de3bdab2ab9e2e9fd08f97c865ef |
| identifier_str_mv | 1936-959X Mawad, M. E., Mawad, J. K., Cartwright, J., & Gokaslan, Z. (1995). Long-term histopathologic changes in canine aneurysms embolized with Guglielmi detachable coils. American journal of neuroradiology, 16(1), 7-13. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/10993 |
| publishDate | 1995 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Long-term histopathologic changes in canine aneurysms embolized with Guglielmi detachable coilsMawad, Michel E.Mawad, Janine K.Carterwright, JoinerGokaslan, ZiyaPURPOSE To evaluate the long-term histologic changes, including those in the ultrastructure of the neoendothelium, occurring in experimental canine aneurysms obliterated with Guglielmi detachable coils. METHODS Ten experimental aneurysms were surgically created in mongrel dogs using side-to-side jugular carotid fistulas that were subsequently ligated to form blind pouch venous aneurysms dependent on the carotid circulation. The aneurysms were obliterated with Guglielmi detachable coils, and the animals were kept in observation. Six months after the endovascular obliteration of the aneurysms, repeat carotid arteriography was performed to assess for potential recanalization of the aneurysms. The animals were then killed and submitted for autopsy. The carotid artery and the embolized aneurysm were resected and studied with light and electron microscopy. RESULTS Both completely obliterated and recanalized aneurysms were excluded from the parent circulation by an endothelialized layer of connective tissue. The fundus of the aneurysm was completely obliterated by heavy reactive fibrous tissue surrounding the coils with very minimal, if any, inflammatory reaction. The neointima is composed of three well-identifiable layers, the most superficial of which is formed of new endothelial cells positioned next to each other in a cobblestone fashion over a basal membrane. CONCLUSION In the absence of histologic data in human aneurysms obliterated with Guglielmi detachable coils, several observations made in our experimental study help in the understanding of the long-term results expected from this endovascular technique.PublishedN/A2019-07-08T09:41:27Z2019-07-08T09:41:27Z19952019-07-08Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1936-959Xhttp://hdl.handle.net/10725/10993Mawad, M. E., Mawad, J. K., Cartwright, J., & Gokaslan, Z. (1995). Long-term histopathologic changes in canine aneurysms embolized with Guglielmi detachable coils. American journal of neuroradiology, 16(1), 7-13.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttp://www.ajnr.org/content/16/1/7.shortenAmerican Journal of Neuroradiologyinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/109932021-03-19T10:45:20Z |
| spellingShingle | Long-term histopathologic changes in canine aneurysms embolized with Guglielmi detachable coils Mawad, Michel E. |
| status_str | publishedVersion |
| title | Long-term histopathologic changes in canine aneurysms embolized with Guglielmi detachable coils |
| title_full | Long-term histopathologic changes in canine aneurysms embolized with Guglielmi detachable coils |
| title_fullStr | Long-term histopathologic changes in canine aneurysms embolized with Guglielmi detachable coils |
| title_full_unstemmed | Long-term histopathologic changes in canine aneurysms embolized with Guglielmi detachable coils |
| title_short | Long-term histopathologic changes in canine aneurysms embolized with Guglielmi detachable coils |
| title_sort | Long-term histopathologic changes in canine aneurysms embolized with Guglielmi detachable coils |
| url | http://hdl.handle.net/10725/10993 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.ajnr.org/content/16/1/7.short |