Clinicopathologic studies of age-related macular degeneration with classic subfoveal choroidal neovascularization treated with photodynamic therapy
Background Photodynamic therapy (PDT) is a relatively new modality that is currently under clinical and experimental evaluation for treatment of subfoveal choroidal neovascularization (CNV). The authors report the case of an 82-year-old woman who underwent verteporfin-mediated PDT for classic subfov...
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2001
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| Online Access: | http://hdl.handle.net/10725/10799 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://oce.ovid.com/article/00006982-200110000-00010/HTML |
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| author | Ghazi, Nicola G. |
| author2 | Jabbour, Nabil M. De la Cruz, Zenaida Green, Richard |
| author2_role | author author author |
| author_facet | Ghazi, Nicola G. Jabbour, Nabil M. De la Cruz, Zenaida Green, Richard |
| author_role | author |
| dc.creator.none.fl_str_mv | Ghazi, Nicola G. Jabbour, Nabil M. De la Cruz, Zenaida Green, Richard |
| dc.date.none.fl_str_mv | 2001 2019-06-13T09:52:12Z 2019-06-13T09:52:12Z 2019-06-13 |
| dc.identifier.none.fl_str_mv | 1539-2864 http://hdl.handle.net/10725/10799 Ghazi, N. G., Jabbour, N. M., DE LA CRUZ, Z. C., & Green, W. R. (2001). Clinicopathologic studies of age-related macular degeneration with classic subfoveal choroidal neovascularization treated with photodynamic therapy. Retina, 21(5), 478-486. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://oce.ovid.com/article/00006982-200110000-00010/HTML |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Retina |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Clinicopathologic studies of age-related macular degeneration with classic subfoveal choroidal neovascularization treated with photodynamic therapy |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Background Photodynamic therapy (PDT) is a relatively new modality that is currently under clinical and experimental evaluation for treatment of subfoveal choroidal neovascularization (CNV). The authors report the case of an 82-year-old woman who underwent verteporfin-mediated PDT for classic subfoveal CNV. Fluorescein angiography performed 2 weeks after treatment disclosed reduction of the initial area of neovascularization and leakage by approximately 60%. Three weeks after PDT, however, the area of leakage was almost the same size as that before treatment. The patient underwent submacular membranectomy almost 4 weeks after treatment. The authors describe the ultrastructural vascular changes after PDT and a clinicopathologic study of classic CNV. Methods The submacular membrane was studied by light and electron microscopy and immunohistochemical techniques. Results Ultrastructural examination of the peripheral vessels showed evidence of endothelial cell degeneration with platelet aggregation and thrombus formation. Occasional occluded vessels were surrounded by macrophages, a phenomenon previously reported to describe the process of resorption of such blood vessels. The vessels in the center of the membrane were unremarkable. Conclusion Photodynamic therapy causes endothelial cell damage, thrombus formation, and vascular occlusion of classic CNV in age-related macular degeneration. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_d4da38b7eef8dead63ebca313990b0e1 |
| identifier_str_mv | 1539-2864 Ghazi, N. G., Jabbour, N. M., DE LA CRUZ, Z. C., & Green, W. R. (2001). Clinicopathologic studies of age-related macular degeneration with classic subfoveal choroidal neovascularization treated with photodynamic therapy. Retina, 21(5), 478-486. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/10799 |
| publishDate | 2001 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
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| spelling | Clinicopathologic studies of age-related macular degeneration with classic subfoveal choroidal neovascularization treated with photodynamic therapyGhazi, Nicola G.Jabbour, Nabil M.De la Cruz, ZenaidaGreen, RichardBackground Photodynamic therapy (PDT) is a relatively new modality that is currently under clinical and experimental evaluation for treatment of subfoveal choroidal neovascularization (CNV). The authors report the case of an 82-year-old woman who underwent verteporfin-mediated PDT for classic subfoveal CNV. Fluorescein angiography performed 2 weeks after treatment disclosed reduction of the initial area of neovascularization and leakage by approximately 60%. Three weeks after PDT, however, the area of leakage was almost the same size as that before treatment. The patient underwent submacular membranectomy almost 4 weeks after treatment. The authors describe the ultrastructural vascular changes after PDT and a clinicopathologic study of classic CNV. Methods The submacular membrane was studied by light and electron microscopy and immunohistochemical techniques. Results Ultrastructural examination of the peripheral vessels showed evidence of endothelial cell degeneration with platelet aggregation and thrombus formation. Occasional occluded vessels were surrounded by macrophages, a phenomenon previously reported to describe the process of resorption of such blood vessels. The vessels in the center of the membrane were unremarkable. Conclusion Photodynamic therapy causes endothelial cell damage, thrombus formation, and vascular occlusion of classic CNV in age-related macular degeneration.PublishedN/A2019-06-13T09:52:12Z2019-06-13T09:52:12Z20012019-06-13Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1539-2864http://hdl.handle.net/10725/10799Ghazi, N. G., Jabbour, N. M., DE LA CRUZ, Z. C., & Green, W. R. (2001). Clinicopathologic studies of age-related macular degeneration with classic subfoveal choroidal neovascularization treated with photodynamic therapy. Retina, 21(5), 478-486.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://oce.ovid.com/article/00006982-200110000-00010/HTMLenRetinainfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/107992021-03-19T10:45:17Z |
| spellingShingle | Clinicopathologic studies of age-related macular degeneration with classic subfoveal choroidal neovascularization treated with photodynamic therapy Ghazi, Nicola G. |
| status_str | publishedVersion |
| title | Clinicopathologic studies of age-related macular degeneration with classic subfoveal choroidal neovascularization treated with photodynamic therapy |
| title_full | Clinicopathologic studies of age-related macular degeneration with classic subfoveal choroidal neovascularization treated with photodynamic therapy |
| title_fullStr | Clinicopathologic studies of age-related macular degeneration with classic subfoveal choroidal neovascularization treated with photodynamic therapy |
| title_full_unstemmed | Clinicopathologic studies of age-related macular degeneration with classic subfoveal choroidal neovascularization treated with photodynamic therapy |
| title_short | Clinicopathologic studies of age-related macular degeneration with classic subfoveal choroidal neovascularization treated with photodynamic therapy |
| title_sort | Clinicopathologic studies of age-related macular degeneration with classic subfoveal choroidal neovascularization treated with photodynamic therapy |
| url | http://hdl.handle.net/10725/10799 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://oce.ovid.com/article/00006982-200110000-00010/HTML |