Inhibitor development in correlation to factor VIII genotypes
Alloantibodies (inhibitors) against factor VIII (FVIII) develop in 20–30% of patients with severe haemophilia A and render classical FVIII substitution therapy ineffective. Several studies have shown that genetic factors, the type of FVIII gene mutation and immune response genes (e.g. the Major Hist...
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2002
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| Online Access: | http://hdl.handle.net/10725/6202 http://dx.doi.org/10.1046/j.1351-8216.2001.00134.x http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://onlinelibrary.wiley.com/doi/10.1046/j.1351-8216.2001.00134.x/full |
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