Comparison between desferrioxamine and combined therapy with desferrioxamine and deferiprone in iron overloaded thalassaemia patients
Summary. Desferrioxamine (DFX) alone (40–50 mg/kg/d s.c. over 8–12 h, five times weekly) was compared with combined DFX twice weekly and deferiprone (75 mg/kg/d) over 12 months in previously poorly chelated thalassaemia patients. Serum ferritin fell from 5506 ± 635 µg/l (mean ± SEM) to 3998 ± 604 µg...
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2003
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| Online Access: | http://hdl.handle.net/10725/3920 http://dx.doi.org/10.1046/j.1365-2141.2003.04240.x http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2141.2003.04240.x/full |
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| _version_ | 1864513462493773824 |
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| author | Mourad, Fadi H. |
| author2 | Hoffbrand, A. Victor Sheikh-Taha, Marwan Koussa, Susane Khoriaty, Adlette I. Taher, Ali |
| author2_role | author author author author author |
| author_facet | Mourad, Fadi H. Hoffbrand, A. Victor Sheikh-Taha, Marwan Koussa, Susane Khoriaty, Adlette I. Taher, Ali |
| author_role | author |
| dc.creator.none.fl_str_mv | Mourad, Fadi H. Hoffbrand, A. Victor Sheikh-Taha, Marwan Koussa, Susane Khoriaty, Adlette I. Taher, Ali |
| dc.date.none.fl_str_mv | 2003 2016-06-01T12:05:15Z 2016-06-01T12:05:15Z 2016-06-01 |
| dc.identifier.none.fl_str_mv | 0007-1048 http://hdl.handle.net/10725/3920 http://dx.doi.org/10.1046/j.1365-2141.2003.04240.x Mourad, F. H., Hoffbrand, A. V., Sheikh‐Taha, M., Koussa, S., Khoriaty, A. I., & Taher, A. (2003). Comparison between desferrioxamine and combined therapy with desferrioxamine and deferiprone in iron overloaded thalassaemia patients. British journal of haematology, 121(1), 187-189. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2141.2003.04240.x/full |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | British Journal of Haematology |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Comparison between desferrioxamine and combined therapy with desferrioxamine and deferiprone in iron overloaded thalassaemia patients |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Summary. Desferrioxamine (DFX) alone (40–50 mg/kg/d s.c. over 8–12 h, five times weekly) was compared with combined DFX twice weekly and deferiprone (75 mg/kg/d) over 12 months in previously poorly chelated thalassaemia patients. Serum ferritin fell from 5506 ± 635 µg/l (mean ± SEM) to 3998 ± 604 µg/l (P < 0·001; n = 14) in the DFX group and from 4153 ± 517 µg/l to 2805 ± 327 µg/l in the combined group (P < 0·01; n = 11). Deferiprone plus DFX produced a greater mean urine iron excretion (1·01 mg/kg/24 h) than iron intake from blood transfusion in each patient. Main side-effects were skin reactions (DFX alone), nausea and arthralgia (combined therapy). As chelation therapy, the combined protocol was as effective as DFX five times weekly. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_d681c60e805b60fd9342a1eed82beec5 |
| identifier_str_mv | 0007-1048 Mourad, F. H., Hoffbrand, A. V., Sheikh‐Taha, M., Koussa, S., Khoriaty, A. I., & Taher, A. (2003). Comparison between desferrioxamine and combined therapy with desferrioxamine and deferiprone in iron overloaded thalassaemia patients. British journal of haematology, 121(1), 187-189. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/3920 |
| publishDate | 2003 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Comparison between desferrioxamine and combined therapy with desferrioxamine and deferiprone in iron overloaded thalassaemia patientsMourad, Fadi H.Hoffbrand, A. VictorSheikh-Taha, MarwanKoussa, SusaneKhoriaty, Adlette I.Taher, AliSummary. Desferrioxamine (DFX) alone (40–50 mg/kg/d s.c. over 8–12 h, five times weekly) was compared with combined DFX twice weekly and deferiprone (75 mg/kg/d) over 12 months in previously poorly chelated thalassaemia patients. Serum ferritin fell from 5506 ± 635 µg/l (mean ± SEM) to 3998 ± 604 µg/l (P < 0·001; n = 14) in the DFX group and from 4153 ± 517 µg/l to 2805 ± 327 µg/l in the combined group (P < 0·01; n = 11). Deferiprone plus DFX produced a greater mean urine iron excretion (1·01 mg/kg/24 h) than iron intake from blood transfusion in each patient. Main side-effects were skin reactions (DFX alone), nausea and arthralgia (combined therapy). As chelation therapy, the combined protocol was as effective as DFX five times weekly.PublishedN/A2016-06-01T12:05:15Z2016-06-01T12:05:15Z20032016-06-01Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0007-1048http://hdl.handle.net/10725/3920http://dx.doi.org/10.1046/j.1365-2141.2003.04240.xMourad, F. H., Hoffbrand, A. V., Sheikh‐Taha, M., Koussa, S., Khoriaty, A. I., & Taher, A. (2003). Comparison between desferrioxamine and combined therapy with desferrioxamine and deferiprone in iron overloaded thalassaemia patients. British journal of haematology, 121(1), 187-189.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttp://onlinelibrary.wiley.com/doi/10.1046/j.1365-2141.2003.04240.x/fullenBritish Journal of Haematologyinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/39202021-03-19T10:00:49Z |
| spellingShingle | Comparison between desferrioxamine and combined therapy with desferrioxamine and deferiprone in iron overloaded thalassaemia patients Mourad, Fadi H. |
| status_str | publishedVersion |
| title | Comparison between desferrioxamine and combined therapy with desferrioxamine and deferiprone in iron overloaded thalassaemia patients |
| title_full | Comparison between desferrioxamine and combined therapy with desferrioxamine and deferiprone in iron overloaded thalassaemia patients |
| title_fullStr | Comparison between desferrioxamine and combined therapy with desferrioxamine and deferiprone in iron overloaded thalassaemia patients |
| title_full_unstemmed | Comparison between desferrioxamine and combined therapy with desferrioxamine and deferiprone in iron overloaded thalassaemia patients |
| title_short | Comparison between desferrioxamine and combined therapy with desferrioxamine and deferiprone in iron overloaded thalassaemia patients |
| title_sort | Comparison between desferrioxamine and combined therapy with desferrioxamine and deferiprone in iron overloaded thalassaemia patients |
| url | http://hdl.handle.net/10725/3920 http://dx.doi.org/10.1046/j.1365-2141.2003.04240.x http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2141.2003.04240.x/full |