Characterization of the Cytotoxic Mechanism and Mode of Cell Death Induced by a MEK1/2-selective version of Anthrax Lethal Toxin (PrAg/LFW271A) in Acute Myeloid Leukemia

Characterization of the Cytotoxic Mechanism and Mode of Cell Death Induced by a MEK1/2-selective version of Anthrax Lethal Toxin (PrAg/LFW271A) in Acute Myeloid Leukemia

Wild-type anthrax lethal toxin (PrAg/LF) demonstrated high potency in inhibiting the MAPK pathway in AML cell lines that rely on this pathway for survival. PrAg/LF is a binary toxin consisting of protective antigen (PrAg), that serves as the tumor specific delivery protein, and the wild-type effecto...

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Bibliographic Details
Main Author: Mroue, Zeinab (author)
Format: masterThesis
Published: 2023
Subjects:
Acute myeloid leukemia > Pathogensis
Mitogen-activated protein kinases
Protein kinases > Inhibitors
Autophagic vacuoles
Lebanese American University > Dissertations
Dissertations, Academic
Online Access:http://hdl.handle.net/10725/15083
https://doi.org/10.26756/th.2023.584
http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php
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http://hdl.handle.net/10725/15083
https://doi.org/10.26756/th.2023.584
http://libraries.lau.edu.lb/research/laur/terms-of-use/thesis.php

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