Fatigue in multiple sclerosis
Multiple sclerosis (MS) is a chronic progressive inflammatory disease of the central nervous system (CNS) and the major cause of non-traumatic disability in young adults. Fatigue is a frequent symptom reported by the majority of MS patients during their disease course and drastically affects their q...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , |
| التنسيق: | article |
| منشور في: |
2015
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/10512 https://doi.org/10.3389/fncel.2015.00460 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.frontiersin.org/articles/10.3389/fncel.2015.00460/full |
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| _version_ | 1864513486663450624 |
|---|---|
| author | Riachi, Naji |
| author2 | Ahdab, Rechdi Challah, Moussa A. Creange, Alain Lefaucheur, Jean-Pascal Ayache, Samar S. |
| author2_role | author author author author author |
| author_facet | Riachi, Naji Ahdab, Rechdi Challah, Moussa A. Creange, Alain Lefaucheur, Jean-Pascal Ayache, Samar S. |
| author_role | author |
| dc.creator.none.fl_str_mv | Riachi, Naji Ahdab, Rechdi Challah, Moussa A. Creange, Alain Lefaucheur, Jean-Pascal Ayache, Samar S. |
| dc.date.none.fl_str_mv | 2015 2019-04-30T13:10:30Z 2019-04-30T13:10:30Z 2019-04-30 |
| dc.identifier.none.fl_str_mv | 1662-5102 http://hdl.handle.net/10725/10512 https://doi.org/10.3389/fncel.2015.00460 Chalah, M. A., Riachi, N., Ahdab, R., Créange, A., Lefaucheur, J. P., & Ayache, S. S. (2015). Fatigue in multiple sclerosis: neural correlates and the role of non-invasive brain stimulation. Frontiers in cellular neuroscience, 9, 460. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.frontiersin.org/articles/10.3389/fncel.2015.00460/full |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Frontiers in Cellular Neuroscience |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Fatigue in multiple sclerosis neural correlates and the role of non-invasive brain stimulation |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Multiple sclerosis (MS) is a chronic progressive inflammatory disease of the central nervous system (CNS) and the major cause of non-traumatic disability in young adults. Fatigue is a frequent symptom reported by the majority of MS patients during their disease course and drastically affects their quality of life. Despite its significant prevalence and impact, the underlying pathophysiological mechanisms are not well elucidated. MS fatigue is still considered the result of multifactorial and complex constellations, and is commonly classified into “primary” fatigue related to the pathological changes of the disease itself, and “secondary” fatigue attributed to mimicking symptoms, comorbid sleep and mood disorders, and medications side effects. Radiological, physiological, and endocrine data have raised hypotheses regarding the origin of this symptom, some of which have succeeded in identifying an association between MS fatigue and structural or functional abnormalities within various brain networks. Hence, the aim of this work is to reappraise the neural correlates of MS fatigue and to discuss the rationale for the emergent use of noninvasive brain stimulation (NIBS) techniques as potential treatments. This will include a presentation of the various NIBS modalities and a suggestion of their potential mechanisms of action in this context. Specific issues related to the value of transcranial direct current stimulation (tDCS) will be addressed |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_da47c10f77f7eb2333d7bed84ddadfcd |
| identifier_str_mv | 1662-5102 Chalah, M. A., Riachi, N., Ahdab, R., Créange, A., Lefaucheur, J. P., & Ayache, S. S. (2015). Fatigue in multiple sclerosis: neural correlates and the role of non-invasive brain stimulation. Frontiers in cellular neuroscience, 9, 460. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/10512 |
| publishDate | 2015 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Fatigue in multiple sclerosisneural correlates and the role of non-invasive brain stimulationRiachi, NajiAhdab, RechdiChallah, Moussa A.Creange, AlainLefaucheur, Jean-PascalAyache, Samar S.Multiple sclerosis (MS) is a chronic progressive inflammatory disease of the central nervous system (CNS) and the major cause of non-traumatic disability in young adults. Fatigue is a frequent symptom reported by the majority of MS patients during their disease course and drastically affects their quality of life. Despite its significant prevalence and impact, the underlying pathophysiological mechanisms are not well elucidated. MS fatigue is still considered the result of multifactorial and complex constellations, and is commonly classified into “primary” fatigue related to the pathological changes of the disease itself, and “secondary” fatigue attributed to mimicking symptoms, comorbid sleep and mood disorders, and medications side effects. Radiological, physiological, and endocrine data have raised hypotheses regarding the origin of this symptom, some of which have succeeded in identifying an association between MS fatigue and structural or functional abnormalities within various brain networks. Hence, the aim of this work is to reappraise the neural correlates of MS fatigue and to discuss the rationale for the emergent use of noninvasive brain stimulation (NIBS) techniques as potential treatments. This will include a presentation of the various NIBS modalities and a suggestion of their potential mechanisms of action in this context. Specific issues related to the value of transcranial direct current stimulation (tDCS) will be addressedPublishedN/A2019-04-30T13:10:30Z2019-04-30T13:10:30Z20152019-04-30Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1662-5102http://hdl.handle.net/10725/10512https://doi.org/10.3389/fncel.2015.00460Chalah, M. A., Riachi, N., Ahdab, R., Créange, A., Lefaucheur, J. P., & Ayache, S. S. (2015). Fatigue in multiple sclerosis: neural correlates and the role of non-invasive brain stimulation. Frontiers in cellular neuroscience, 9, 460.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://www.frontiersin.org/articles/10.3389/fncel.2015.00460/fullenFrontiers in Cellular Neuroscienceinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/105122021-03-19T10:45:22Z |
| spellingShingle | Fatigue in multiple sclerosis Riachi, Naji |
| status_str | publishedVersion |
| title | Fatigue in multiple sclerosis |
| title_full | Fatigue in multiple sclerosis |
| title_fullStr | Fatigue in multiple sclerosis |
| title_full_unstemmed | Fatigue in multiple sclerosis |
| title_short | Fatigue in multiple sclerosis |
| title_sort | Fatigue in multiple sclerosis |
| url | http://hdl.handle.net/10725/10512 https://doi.org/10.3389/fncel.2015.00460 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.frontiersin.org/articles/10.3389/fncel.2015.00460/full |