Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration

Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration

Oncogenic transformation of postmitotic neurons triggers cell death, but the identity of genes critical for degeneration remain unclear. The antitumor antibiotic mithramycin prolongs survival of mouse models of Huntington's disease in vivo and inhibits oxidative stress-induced death in cortical...

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Bibliographic Details
Main Author: Sleiman, Sama F. (author)
Other Authors: Langley, Brett C. (author), Berlin, Jill (author), Xia, Li (author), Payappilly, Jimmy B. (author), Kharel, Madan K. (author), Guo, Hengchang (author), Thonpson, Leslie Michels (author), Mahishi, Lata (author), Ahuja, Preeti (author), Maclellan, W. Robb (author), Geschwind, Daniel H. (author), Coppola, Giovanni (author), Rohr, Jurgen (author), Ratan, Rajiv R. (author)
Format: article
Published: 2011
Online Access:http://hdl.handle.net/10725/6141
https://doi.org/10.1523/JNEUROSCI.0710-11.2011
http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php
http://www.jneurosci.org/content/31/18/6858.short
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http://hdl.handle.net/10725/6141
https://doi.org/10.1523/JNEUROSCI.0710-11.2011
http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php
http://www.jneurosci.org/content/31/18/6858.short

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