Cytotoxicity modulation of ruthenium(II) tris-bathophenanthroline complexes with systematically varied charge
A series of four ruthenium(II) complexes Ru(bp)n(bps)3-n (n = 0-3; bp = 4,7-diphenyl-1,10-phenanthroline or bathophenanthroline; and bps = disulfonated 4,7-diphenyl-1,10-phenanthroline or bathophenanthroline disulfonate) bearing different charges were synthesized and characterized. In aqueous media,...
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| مؤلفون آخرون: | , , , , , , |
| التنسيق: | article |
| منشور في: |
2018
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/11362 https://doi.org/10.1016/j.jphotochem.2017.10.007 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.sciencedirect.com/science/article/pii/S1010603017306172 |
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| _version_ | 1864513488681959424 |
|---|---|
| author | Audi, Hassib |
| author2 | Azar, Daniel F. Mahjoub, Farah Farhat, Stephanie El Masri, Zeinab El-Sibai, Mirvat Abi-Habib, Ralph J. Khnayzer, Rony S. |
| author2_role | author author author author author author author |
| author_facet | Audi, Hassib Azar, Daniel F. Mahjoub, Farah Farhat, Stephanie El Masri, Zeinab El-Sibai, Mirvat Abi-Habib, Ralph J. Khnayzer, Rony S. |
| author_role | author |
| dc.creator.none.fl_str_mv | Audi, Hassib Azar, Daniel F. Mahjoub, Farah Farhat, Stephanie El Masri, Zeinab El-Sibai, Mirvat Abi-Habib, Ralph J. Khnayzer, Rony S. |
| dc.date.none.fl_str_mv | 2018 2019-10-02T10:53:27Z 2019-10-02T10:53:27Z 2019-10-02 |
| dc.identifier.none.fl_str_mv | 1010-6030 http://hdl.handle.net/10725/11362 https://doi.org/10.1016/j.jphotochem.2017.10.007 Audi, H., Azar, D. F., Mahjoub, F., Farhat, S., El Masri, Z., El-Sibai, M., ... & Khnayzer, R. S. (2018). Cytotoxicity modulation of ruthenium (II) tris-bathophenanthroline complexes with systematically varied charge. Journal of Photochemistry and Photobiology A: Chemistry, 351, 59-68. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.sciencedirect.com/science/article/pii/S1010603017306172 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Journal of Photochemistry and Photobiology A: Chemistry |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Cytotoxicity modulation of ruthenium(II) tris-bathophenanthroline complexes with systematically varied charge |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | A series of four ruthenium(II) complexes Ru(bp)n(bps)3-n (n = 0-3; bp = 4,7-diphenyl-1,10-phenanthroline or bathophenanthroline; and bps = disulfonated 4,7-diphenyl-1,10-phenanthroline or bathophenanthroline disulfonate) bearing different charges were synthesized and characterized. In aqueous media, all complexes displayed similar photophysical properties which makes this series ideal to study the effect of charge on the cytotoxicity of Ru(II) complexes. Ru(bp)32+ (1) and Ru(bps)34− (4) are known photosensitizers that penetrate cancer cells and possess a significant light-induced cytotoxicity. The newly conceived neutral Ru(bp)2(bps)0 (2) and dianionic Ru(bp)(bps)22− (3) were also found to have significant uptake as well as light-activation properties. Importantly, the cytotoxicity in the dark was successfully tuned upon systematic charge modulation of the complexes. The cationic complex 1 was potent against 5 out of 6 cell lines tested (MDA-MB-231, MCF-7, B16, SF and ML2) and displayed the highest cytotoxicity among the tested complexes with IC50 values of 4.0, 3.6, 1.7, 1.0 and 2.9 μM, respectively. The two anionic complexes, 3 and 4, with respective overall charges of −2 and −4, were not potent against any of the cell lines in the dark (IC50 > 200 μM), whereas the neutral molecule, complex 2, was potent against 3 out of 6 cell lines in the dark (B16, SF and ML2) and exhibited an intermediate activity with IC50 values of 12.8, 3.0 and 10.3 μM, respectively. All complexes presented significant phototoxicity when activated at 6 h post-incubation, which is consistent with their fast uptake and ability to produce singlet oxygen. The localization of complexes 1–4 within the cells was found to be dependent on the charge and photoexcitation conditions. The charge-activity relationship elucidated in this work facilitates the development of new sensitizers for photodynamic therapy. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_dd636cd29f087bd62baea0f897646ff9 |
| identifier_str_mv | 1010-6030 Audi, H., Azar, D. F., Mahjoub, F., Farhat, S., El Masri, Z., El-Sibai, M., ... & Khnayzer, R. S. (2018). Cytotoxicity modulation of ruthenium (II) tris-bathophenanthroline complexes with systematically varied charge. Journal of Photochemistry and Photobiology A: Chemistry, 351, 59-68. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/11362 |
| publishDate | 2018 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Cytotoxicity modulation of ruthenium(II) tris-bathophenanthroline complexes with systematically varied chargeAudi, HassibAzar, Daniel F.Mahjoub, FarahFarhat, StephanieEl Masri, ZeinabEl-Sibai, MirvatAbi-Habib, Ralph J.Khnayzer, Rony S.A series of four ruthenium(II) complexes Ru(bp)n(bps)3-n (n = 0-3; bp = 4,7-diphenyl-1,10-phenanthroline or bathophenanthroline; and bps = disulfonated 4,7-diphenyl-1,10-phenanthroline or bathophenanthroline disulfonate) bearing different charges were synthesized and characterized. In aqueous media, all complexes displayed similar photophysical properties which makes this series ideal to study the effect of charge on the cytotoxicity of Ru(II) complexes. Ru(bp)32+ (1) and Ru(bps)34− (4) are known photosensitizers that penetrate cancer cells and possess a significant light-induced cytotoxicity. The newly conceived neutral Ru(bp)2(bps)0 (2) and dianionic Ru(bp)(bps)22− (3) were also found to have significant uptake as well as light-activation properties. Importantly, the cytotoxicity in the dark was successfully tuned upon systematic charge modulation of the complexes. The cationic complex 1 was potent against 5 out of 6 cell lines tested (MDA-MB-231, MCF-7, B16, SF and ML2) and displayed the highest cytotoxicity among the tested complexes with IC50 values of 4.0, 3.6, 1.7, 1.0 and 2.9 μM, respectively. The two anionic complexes, 3 and 4, with respective overall charges of −2 and −4, were not potent against any of the cell lines in the dark (IC50 > 200 μM), whereas the neutral molecule, complex 2, was potent against 3 out of 6 cell lines in the dark (B16, SF and ML2) and exhibited an intermediate activity with IC50 values of 12.8, 3.0 and 10.3 μM, respectively. All complexes presented significant phototoxicity when activated at 6 h post-incubation, which is consistent with their fast uptake and ability to produce singlet oxygen. The localization of complexes 1–4 within the cells was found to be dependent on the charge and photoexcitation conditions. The charge-activity relationship elucidated in this work facilitates the development of new sensitizers for photodynamic therapy.PublishedN/A2019-10-02T10:53:27Z2019-10-02T10:53:27Z20182019-10-02Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1010-6030http://hdl.handle.net/10725/11362https://doi.org/10.1016/j.jphotochem.2017.10.007Audi, H., Azar, D. F., Mahjoub, F., Farhat, S., El Masri, Z., El-Sibai, M., ... & Khnayzer, R. S. (2018). Cytotoxicity modulation of ruthenium (II) tris-bathophenanthroline complexes with systematically varied charge. Journal of Photochemistry and Photobiology A: Chemistry, 351, 59-68.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://www.sciencedirect.com/science/article/pii/S1010603017306172enJournal of Photochemistry and Photobiology A: Chemistryinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/113622021-03-19T10:47:37Z |
| spellingShingle | Cytotoxicity modulation of ruthenium(II) tris-bathophenanthroline complexes with systematically varied charge Audi, Hassib |
| status_str | publishedVersion |
| title | Cytotoxicity modulation of ruthenium(II) tris-bathophenanthroline complexes with systematically varied charge |
| title_full | Cytotoxicity modulation of ruthenium(II) tris-bathophenanthroline complexes with systematically varied charge |
| title_fullStr | Cytotoxicity modulation of ruthenium(II) tris-bathophenanthroline complexes with systematically varied charge |
| title_full_unstemmed | Cytotoxicity modulation of ruthenium(II) tris-bathophenanthroline complexes with systematically varied charge |
| title_short | Cytotoxicity modulation of ruthenium(II) tris-bathophenanthroline complexes with systematically varied charge |
| title_sort | Cytotoxicity modulation of ruthenium(II) tris-bathophenanthroline complexes with systematically varied charge |
| url | http://hdl.handle.net/10725/11362 https://doi.org/10.1016/j.jphotochem.2017.10.007 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.sciencedirect.com/science/article/pii/S1010603017306172 |