Fertility drugs and the risk of breast cancer
The risk of breast cancer has been associated with reproductive history. The purpose of this study was to determine the relationship between fertility drugs used in assisted reproductive procedures and the risk of breast cancer. We performed a literature search using the MEDLINE, the COCHRANE Librar...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , , , , , , , , |
| التنسيق: | article |
| منشور في: |
2010
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/2274 http://dx.doi.org/10.1007/s10549-010-1140-4 http://link.springer.com/article/10.1007/s10549-010-1140-4 |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513457873747968 |
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| author | Zreik, Tony |
| author2 | Mazloom, Ali Vannucci, Marina Pinnix, Chilsea Fulton, Stephanie Hadziahmetovic, Mersiha Asmar, Nadia Munkarah, Adnan Ayoub, Chakib M. Shihadeh, Ferial Berjawi, Ghina Hannoun, Antoine Zalloua, Pierre Wogan, Christine Dabaja, Bouthaina |
| author2_role | author author author author author author author author author author author author author author |
| author_facet | Zreik, Tony Mazloom, Ali Vannucci, Marina Pinnix, Chilsea Fulton, Stephanie Hadziahmetovic, Mersiha Asmar, Nadia Munkarah, Adnan Ayoub, Chakib M. Shihadeh, Ferial Berjawi, Ghina Hannoun, Antoine Zalloua, Pierre Wogan, Christine Dabaja, Bouthaina |
| author_role | author |
| dc.creator.none.fl_str_mv | Zreik, Tony Mazloom, Ali Vannucci, Marina Pinnix, Chilsea Fulton, Stephanie Hadziahmetovic, Mersiha Asmar, Nadia Munkarah, Adnan Ayoub, Chakib M. Shihadeh, Ferial Berjawi, Ghina Hannoun, Antoine Zalloua, Pierre Wogan, Christine Dabaja, Bouthaina |
| dc.date.none.fl_str_mv | 2010 2015-10-07T11:15:46Z 2015-10-07T11:15:46Z 2015-10-07 |
| dc.identifier.none.fl_str_mv | 0167-6806 http://hdl.handle.net/10725/2274 http://dx.doi.org/10.1007/s10549-010-1140-4 Zreik, T. G., Mazloom, A., Chen, Y., Vannucci, M., Pinnix, C. C., Fulton, S., ... & Dabaja, B. (2010). Fertility drugs and the risk of breast cancer: a meta-analysis and review. Breast cancer research and treatment, 124(1), 13-26. http://link.springer.com/article/10.1007/s10549-010-1140-4 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Breast cancer research and treatment |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Fertility drugs and the risk of breast cancer A meta-analysis and review |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | The risk of breast cancer has been associated with reproductive history. The purpose of this study was to determine the relationship between fertility drugs used in assisted reproductive procedures and the risk of breast cancer. We performed a literature search using the MEDLINE, the COCHRANE Library, and Scopus to identify studies linking breast cancer to fertility drugs. We excluded case series, case reports, and review articles from our analysis. The study populations included women who were treated for infertility with clomiphene, gonadotropins, gonadotropin-releasing hormones, or other unspecified fertility agents. We extracted information on study design, sample size, type of fertility drugs and number of treatment cycles, breast cancer incidence, and follow-up time from these studies. Eight case–control studies and fifteen cohort studies were included in the quantitative analyses. The Newcastle–Ottawa Quality Assessment Scales were used. Two investigators independently extracted study methods, sources of bias, and outcomes. We found that the risk of breast cancer was not significantly associated with fertility drug treatment. The follow-up periods were short in some of the studies analyzed in our study; however, we proceeded to test the trend in risk estimates across different durations of follow-up and found a trend for association using the nonparametric test; this was interpreted with caution in view of the lack of adjustment with other confounding factors. The current published data do not suggest higher risk of breast cancer in women who receive fertility treatment, but the lack of long-term follow up and the inherent weaknesses in some of the published studies have to be cautiously taken into account. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_e056b2a3f665a49330768a044b9840ae |
| identifier_str_mv | 0167-6806 Zreik, T. G., Mazloom, A., Chen, Y., Vannucci, M., Pinnix, C. C., Fulton, S., ... & Dabaja, B. (2010). Fertility drugs and the risk of breast cancer: a meta-analysis and review. Breast cancer research and treatment, 124(1), 13-26. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/2274 |
| publishDate | 2010 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Fertility drugs and the risk of breast cancerA meta-analysis and reviewZreik, TonyMazloom, AliVannucci, MarinaPinnix, ChilseaFulton, StephanieHadziahmetovic, MersihaAsmar, NadiaMunkarah, AdnanAyoub, Chakib M.Shihadeh, FerialBerjawi, GhinaHannoun, AntoineZalloua, PierreWogan, ChristineDabaja, BouthainaThe risk of breast cancer has been associated with reproductive history. The purpose of this study was to determine the relationship between fertility drugs used in assisted reproductive procedures and the risk of breast cancer. We performed a literature search using the MEDLINE, the COCHRANE Library, and Scopus to identify studies linking breast cancer to fertility drugs. We excluded case series, case reports, and review articles from our analysis. The study populations included women who were treated for infertility with clomiphene, gonadotropins, gonadotropin-releasing hormones, or other unspecified fertility agents. We extracted information on study design, sample size, type of fertility drugs and number of treatment cycles, breast cancer incidence, and follow-up time from these studies. Eight case–control studies and fifteen cohort studies were included in the quantitative analyses. The Newcastle–Ottawa Quality Assessment Scales were used. Two investigators independently extracted study methods, sources of bias, and outcomes. We found that the risk of breast cancer was not significantly associated with fertility drug treatment. The follow-up periods were short in some of the studies analyzed in our study; however, we proceeded to test the trend in risk estimates across different durations of follow-up and found a trend for association using the nonparametric test; this was interpreted with caution in view of the lack of adjustment with other confounding factors. The current published data do not suggest higher risk of breast cancer in women who receive fertility treatment, but the lack of long-term follow up and the inherent weaknesses in some of the published studies have to be cautiously taken into account.PublishedN/A2015-10-07T11:15:46Z2015-10-07T11:15:46Z20102015-10-07Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0167-6806http://hdl.handle.net/10725/2274http://dx.doi.org/10.1007/s10549-010-1140-4Zreik, T. G., Mazloom, A., Chen, Y., Vannucci, M., Pinnix, C. C., Fulton, S., ... & Dabaja, B. (2010). Fertility drugs and the risk of breast cancer: a meta-analysis and review. Breast cancer research and treatment, 124(1), 13-26.http://link.springer.com/article/10.1007/s10549-010-1140-4enBreast cancer research and treatmentinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/22742019-07-22T06:10:36Z |
| spellingShingle | Fertility drugs and the risk of breast cancer Zreik, Tony |
| status_str | publishedVersion |
| title | Fertility drugs and the risk of breast cancer |
| title_full | Fertility drugs and the risk of breast cancer |
| title_fullStr | Fertility drugs and the risk of breast cancer |
| title_full_unstemmed | Fertility drugs and the risk of breast cancer |
| title_short | Fertility drugs and the risk of breast cancer |
| title_sort | Fertility drugs and the risk of breast cancer |
| url | http://hdl.handle.net/10725/2274 http://dx.doi.org/10.1007/s10549-010-1140-4 http://link.springer.com/article/10.1007/s10549-010-1140-4 |