Genomic attributes of extended-spectrum β-lactamase-producing Escherichia coli isolated from patients in Lebanon
Aim: Extended-spectrum β-lactamase-producing (ESBL) Escherichia coli are a public threat worldwide. This study aimed at analyzing the genomic and functional attributes of nine ESBLs taken from rectal swabs. Materials & methods: Samples were isolated from patients admitted for gastrointestinal an...
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| Other Authors: | , , , , , |
| Format: | article |
| Published: |
2017
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| Online Access: | http://hdl.handle.net/10725/8092 https://doi.org/10.2217/fmb-2017-0171 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.futuremedicine.com/doi/abs/10.2217/fmb-2017-0171 |
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| Summary: | Aim: Extended-spectrum β-lactamase-producing (ESBL) Escherichia coli are a public threat worldwide. This study aimed at analyzing the genomic and functional attributes of nine ESBLs taken from rectal swabs. Materials & methods: Samples were isolated from patients admitted for gastrointestinal and urological procedures at the University Medical Center-Rizk Hospital (UMCRH) in Lebanon. Illumina paired-end libraries were prepared and sequenced. Results: The isolates were distributed into five lineages: ST131, ST648, ST405, ST73 and ST38, and harbored blaOXA-1, blaTEM-1B, blaTEM-1C and aac(6′)Ib-cr. ST131 isolates were carriers of stx2 converting I phage. Conclusion: This is the first comprehensive genomic analysis performed on ESBLs in Lebanon. |
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