Entry of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine into the rat brain
We studied blood-to-brain entry of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 1-methyl-4-phenylpyridinium (MPP+) and butanol in anesthetized rats using the indicator-fractionation method with right atrial bolus injection. Minimal amounts of MPP+, which has low octanol/water partition coeff...
محفوظ في:
| المؤلف الرئيسي: | Riachi, N.J. (author) |
|---|---|
| مؤلفون آخرون: | LaManna, J.C. (author), Harik, S.I. (author) |
| التنسيق: | article |
| منشور في: |
1989
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/10430 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://jpet.aspetjournals.org/content/249/3/744.short |
| الوسوم: |
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مواد مشابهة
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Chemical oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its in vivo metabolism in rat brain and liver
حسب: Riachi, Naji J.
منشور في: (1988) -
On the mechanisms underlying 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity. II. Susceptibility among mammalian species correlates with the toxin's metabolic patterns in brain microvessels and liver
حسب: Riachi, N.J.
منشور في: (1988) -
Development of fluorinated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs with potent nigrostriatal toxicity for potential use in positron emission tomography studies
حسب: Riachi, N.J.
منشور في: (1993) -
Potent neurotoxic fluorinated 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine analogs as potential probes in models of parkinson disease
حسب: Riachi, Naji J.
منشور في: (1988) -
Strain differences in systematic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in mice correlate best with monoamine oxidase activity at the blood-brain barrier
حسب: Riachi, Naji J.
منشور في: (1988)