Gap junctions and Wnt signaling in the mammary gland
Connexins (Cxs), the building blocks of gap junctions (GJs), exhibit spatiotemporal patterns of expression and regulate the development and differentiation of the mammary gland, acting via channel-dependent and channel-independent mechanisms. Impaired Cx expression and localization are reported in b...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , |
| التنسيق: | article |
| منشور في: |
2018
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/11400 https://doi.org/10.1007/s10911-018-9411-5 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://link.springer.com/article/10.1007/s10911-018-9411-5 |
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| _version_ | 1864513488721805312 |
|---|---|
| author | Fostok, Sabreen F. |
| author2 | El-Sibai, Mirvat El-Sabban, Marwan Talhouk, Rabih S. |
| author2_role | author author author |
| author_facet | Fostok, Sabreen F. El-Sibai, Mirvat El-Sabban, Marwan Talhouk, Rabih S. |
| author_role | author |
| dc.creator.none.fl_str_mv | Fostok, Sabreen F. El-Sibai, Mirvat El-Sabban, Marwan Talhouk, Rabih S. |
| dc.date.none.fl_str_mv | 2018 2019-10-09T08:36:07Z 2019-10-09T08:36:07Z 2019-10-09 |
| dc.identifier.none.fl_str_mv | 1573-7039 http://hdl.handle.net/10725/11400 https://doi.org/10.1007/s10911-018-9411-5 Fostok, S. F., El-Sibai, M., El-Sabban, M., & Talhouk, R. S. (2019). Gap junctions and Wnt signaling in the mammary gland: a cross-talk?. Journal of mammary gland biology and neoplasia, 24(1), 17-38. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://link.springer.com/article/10.1007/s10911-018-9411-5 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Journal of Mammary Gland Biology and Neoplasia |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Gap junctions and Wnt signaling in the mammary gland a cross-talk? |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Connexins (Cxs), the building blocks of gap junctions (GJs), exhibit spatiotemporal patterns of expression and regulate the development and differentiation of the mammary gland, acting via channel-dependent and channel-independent mechanisms. Impaired Cx expression and localization are reported in breast cancer, suggesting a tumor suppressive role for Cxs. The signaling events that mediate the role of GJs in the development and tumorigenesis of the mammary gland remain poorly identified. The Wnt pathways, encompassing the canonical or the Wnt/β-catenin pathway and the noncanonical β-catenin-independent pathway, also play important roles in those processes. Indeed, aberrant Wnt signaling is associated with breast cancer. Despite the coincident roles of Cxs and Wnt pathways, the cross-talk in the breast tissue is poorly defined, although this is reported in a number of other tissues. Our previous studies revealed a channel-independent role for Cx43 in inducing differentiation or suppressing tumorigenesis of mammary epithelial cells by acting as a negative regulator of the Wnt/β-catenin pathway. Here, we provide a brief overview of mammary gland development, with emphasis on the role of Cxs in development and tumorigenesis of this tissue. We also discuss the role of Wnt signaling in similar contexts, and review the literature illustrating interplay between Cxs and Wnt pathways. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_e32be49ed97904b6a73b4192c2fe39ac |
| identifier_str_mv | 1573-7039 Fostok, S. F., El-Sibai, M., El-Sabban, M., & Talhouk, R. S. (2019). Gap junctions and Wnt signaling in the mammary gland: a cross-talk?. Journal of mammary gland biology and neoplasia, 24(1), 17-38. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/11400 |
| publishDate | 2018 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Gap junctions and Wnt signaling in the mammary glanda cross-talk?Fostok, Sabreen F.El-Sibai, MirvatEl-Sabban, MarwanTalhouk, Rabih S.Connexins (Cxs), the building blocks of gap junctions (GJs), exhibit spatiotemporal patterns of expression and regulate the development and differentiation of the mammary gland, acting via channel-dependent and channel-independent mechanisms. Impaired Cx expression and localization are reported in breast cancer, suggesting a tumor suppressive role for Cxs. The signaling events that mediate the role of GJs in the development and tumorigenesis of the mammary gland remain poorly identified. The Wnt pathways, encompassing the canonical or the Wnt/β-catenin pathway and the noncanonical β-catenin-independent pathway, also play important roles in those processes. Indeed, aberrant Wnt signaling is associated with breast cancer. Despite the coincident roles of Cxs and Wnt pathways, the cross-talk in the breast tissue is poorly defined, although this is reported in a number of other tissues. Our previous studies revealed a channel-independent role for Cx43 in inducing differentiation or suppressing tumorigenesis of mammary epithelial cells by acting as a negative regulator of the Wnt/β-catenin pathway. Here, we provide a brief overview of mammary gland development, with emphasis on the role of Cxs in development and tumorigenesis of this tissue. We also discuss the role of Wnt signaling in similar contexts, and review the literature illustrating interplay between Cxs and Wnt pathways.PublishedN/A2019-10-09T08:36:07Z2019-10-09T08:36:07Z20182019-10-09Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1573-7039http://hdl.handle.net/10725/11400https://doi.org/10.1007/s10911-018-9411-5Fostok, S. F., El-Sibai, M., El-Sabban, M., & Talhouk, R. S. (2019). Gap junctions and Wnt signaling in the mammary gland: a cross-talk?. Journal of mammary gland biology and neoplasia, 24(1), 17-38.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://link.springer.com/article/10.1007/s10911-018-9411-5enJournal of Mammary Gland Biology and Neoplasiainfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/114002021-03-19T10:47:37Z |
| spellingShingle | Gap junctions and Wnt signaling in the mammary gland Fostok, Sabreen F. |
| status_str | publishedVersion |
| title | Gap junctions and Wnt signaling in the mammary gland |
| title_full | Gap junctions and Wnt signaling in the mammary gland |
| title_fullStr | Gap junctions and Wnt signaling in the mammary gland |
| title_full_unstemmed | Gap junctions and Wnt signaling in the mammary gland |
| title_short | Gap junctions and Wnt signaling in the mammary gland |
| title_sort | Gap junctions and Wnt signaling in the mammary gland |
| url | http://hdl.handle.net/10725/11400 https://doi.org/10.1007/s10911-018-9411-5 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://link.springer.com/article/10.1007/s10911-018-9411-5 |