Vitamin K2 supplementation and arterial stiffness among renal transplant recipients—a single-arm, single-center clinical trial
ubclinical vitamin K deficiency is prevalent among renal transplant recipients and is associated with an increased risk of cardiovascular disease. However, the association between vitamin K supplementation and improvement of arterial stiffness has not been explored in the renal transplant population...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , , , |
| التنسيق: | article |
| منشور في: |
2017
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/10073 http://dx.doi.org/10.1016/j.jash.2017.07.001 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.sciencedirect.com/science/article/pii/S1933171117302553 |
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| _version_ | 1864513485812006912 |
|---|---|
| author | Kilany, Hala |
| author2 | Karam, Albert Bahous, Sola Aoun Mansour, Anthony G. Hariri, Essa Daaboul, Yazan Korjian, Serge El Alam, Andrew Protogerou, Athanase D. Stephan, Antoine |
| author2_role | author author author author author author author author author |
| author_facet | Kilany, Hala Karam, Albert Bahous, Sola Aoun Mansour, Anthony G. Hariri, Essa Daaboul, Yazan Korjian, Serge El Alam, Andrew Protogerou, Athanase D. Stephan, Antoine |
| author_role | author |
| dc.creator.none.fl_str_mv | Kilany, Hala Karam, Albert Bahous, Sola Aoun Mansour, Anthony G. Hariri, Essa Daaboul, Yazan Korjian, Serge El Alam, Andrew Protogerou, Athanase D. Stephan, Antoine |
| dc.date.none.fl_str_mv | 2017 2019-02-22T14:51:26Z 2019-02-22T14:51:26Z 2019-02-22 |
| dc.identifier.none.fl_str_mv | 1933-1711 http://hdl.handle.net/10725/10073 http://dx.doi.org/10.1016/j.jash.2017.07.001 Mansour, A. G., Hariri, E., Daaboul, Y., Korjian, S., El Alam, A., Protogerou, A. D., ... & Bahous, S. A. (2017). Vitamin K2 supplementation and arterial stiffness among renal transplant recipients—a single-arm, single-center clinical trial. Journal of the American Society of Hypertension, 11(9), 589-597. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.sciencedirect.com/science/article/pii/S1933171117302553 |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Journal of the American Society of Hypertension |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Vitamin K2 supplementation and arterial stiffness among renal transplant recipients—a single-arm, single-center clinical trial |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | ubclinical vitamin K deficiency is prevalent among renal transplant recipients and is associated with an increased risk of cardiovascular disease. However, the association between vitamin K supplementation and improvement of arterial stiffness has not been explored in the renal transplant population. The KING trial (vitamin K2 In reNal Graft) is a single-arm study that evaluated the association between the change in vitamin K status and indices of arterial stiffness following 8 weeks of menaquinone-7 (vitamin K2) supplementation (360 μg once daily) among renal transplant recipients (n = 60). Arterial stiffness was measured using carotid-femoral pulse wave velocity (cfPWV). Subclinical vitamin K deficiency was defined as plasma concentration of dephosphorylated-uncarboxylated matrix Gla protein (dp-ucMGP) >500 pmol/L.At baseline, 53.3% of the study subjects had subclinical vitamin K deficiency. Supplementation was associated with a 14.2% reduction in mean cfPWV at 8 weeks (cfPWV pre-vitamin K2 = 9.8 ± 2.2 m/s vs. cfPWV post-vitamin K2 = 8.4 ± 1.5 m/s; P < .001). Mean dp-ucMGP concentrations were also significantly reduced by 55.1% following menaquinone-7 supplementation with a reduction in the prevalence of subclinical deficiency by 40% ( P = .001). When controlled for age, durations of hemodialysis and transplantation, and the change in 24-hour mean arterial pressure, the improvement in arterial stiffness was independently associated with the reduction in dp-ucMGP concentration ( P = .014).Among renal transplant recipients with stable graft function, vitamin K2 supplementation was associated with improvement in subclinical vitamin K deficiency and arterial stiffness |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_e3619d4ceb569630d492d0fa748a1c24 |
| identifier_str_mv | 1933-1711 Mansour, A. G., Hariri, E., Daaboul, Y., Korjian, S., El Alam, A., Protogerou, A. D., ... & Bahous, S. A. (2017). Vitamin K2 supplementation and arterial stiffness among renal transplant recipients—a single-arm, single-center clinical trial. Journal of the American Society of Hypertension, 11(9), 589-597. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/10073 |
| publishDate | 2017 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Vitamin K2 supplementation and arterial stiffness among renal transplant recipients—a single-arm, single-center clinical trialKilany, HalaKaram, AlbertBahous, Sola AounMansour, Anthony G.Hariri, EssaDaaboul, YazanKorjian, SergeEl Alam, AndrewProtogerou, Athanase D.Stephan, Antoineubclinical vitamin K deficiency is prevalent among renal transplant recipients and is associated with an increased risk of cardiovascular disease. However, the association between vitamin K supplementation and improvement of arterial stiffness has not been explored in the renal transplant population. The KING trial (vitamin K2 In reNal Graft) is a single-arm study that evaluated the association between the change in vitamin K status and indices of arterial stiffness following 8 weeks of menaquinone-7 (vitamin K2) supplementation (360 μg once daily) among renal transplant recipients (n = 60). Arterial stiffness was measured using carotid-femoral pulse wave velocity (cfPWV). Subclinical vitamin K deficiency was defined as plasma concentration of dephosphorylated-uncarboxylated matrix Gla protein (dp-ucMGP) >500 pmol/L.At baseline, 53.3% of the study subjects had subclinical vitamin K deficiency. Supplementation was associated with a 14.2% reduction in mean cfPWV at 8 weeks (cfPWV pre-vitamin K2 = 9.8 ± 2.2 m/s vs. cfPWV post-vitamin K2 = 8.4 ± 1.5 m/s; P < .001). Mean dp-ucMGP concentrations were also significantly reduced by 55.1% following menaquinone-7 supplementation with a reduction in the prevalence of subclinical deficiency by 40% ( P = .001). When controlled for age, durations of hemodialysis and transplantation, and the change in 24-hour mean arterial pressure, the improvement in arterial stiffness was independently associated with the reduction in dp-ucMGP concentration ( P = .014).Among renal transplant recipients with stable graft function, vitamin K2 supplementation was associated with improvement in subclinical vitamin K deficiency and arterial stiffnessPublishedN/A2019-02-22T14:51:26Z2019-02-22T14:51:26Z20172019-02-22Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1933-1711http://hdl.handle.net/10725/10073http://dx.doi.org/10.1016/j.jash.2017.07.001Mansour, A. G., Hariri, E., Daaboul, Y., Korjian, S., El Alam, A., Protogerou, A. D., ... & Bahous, S. A. (2017). Vitamin K2 supplementation and arterial stiffness among renal transplant recipients—a single-arm, single-center clinical trial. Journal of the American Society of Hypertension, 11(9), 589-597.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttps://www.sciencedirect.com/science/article/pii/S1933171117302553enJournal of the American Society of Hypertensioninfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/100732021-03-19T10:45:31Z |
| spellingShingle | Vitamin K2 supplementation and arterial stiffness among renal transplant recipients—a single-arm, single-center clinical trial Kilany, Hala |
| status_str | publishedVersion |
| title | Vitamin K2 supplementation and arterial stiffness among renal transplant recipients—a single-arm, single-center clinical trial |
| title_full | Vitamin K2 supplementation and arterial stiffness among renal transplant recipients—a single-arm, single-center clinical trial |
| title_fullStr | Vitamin K2 supplementation and arterial stiffness among renal transplant recipients—a single-arm, single-center clinical trial |
| title_full_unstemmed | Vitamin K2 supplementation and arterial stiffness among renal transplant recipients—a single-arm, single-center clinical trial |
| title_short | Vitamin K2 supplementation and arterial stiffness among renal transplant recipients—a single-arm, single-center clinical trial |
| title_sort | Vitamin K2 supplementation and arterial stiffness among renal transplant recipients—a single-arm, single-center clinical trial |
| url | http://hdl.handle.net/10725/10073 http://dx.doi.org/10.1016/j.jash.2017.07.001 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.sciencedirect.com/science/article/pii/S1933171117302553 |