Stimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in emphysema
Rationale: Vascular endothelial growth factor receptor (VEGFR) inhibition increases ceramides in lung structural cells of the alveolus, initiating apoptosis and alveolar destruction morphologically resembling emphysema. The effects of increased endogenous ceramides could be offset by sphingosine 1-p...
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| Other Authors: | , , , , , |
| Format: | article |
| Published: |
2010
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| Online Access: | http://hdl.handle.net/10725/10036 https://doi.org/10.1164/rccm.200906-0826OC http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php https://www.atsjournals.org/doi/full/10.1164/rccm.200906-0826OC |
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