Budd-Chiari syndrome and heparin-induced thrombocytopenia in polycythemia vera: Successful treatment with repeated TIPS and interferon alpha
Polycythemia vera (PV) is a common cause of Budd-Chiari syndrome (BCS) and portal vein thrombosis (PVT). The postpartum period is a precipitating cofactor. An additional heparin-induced thrombocytopenia/thrombosis (HIT/T) leads to a life-threatening condition in which transjugular intrahepatic porto...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , |
| التنسيق: | article |
| منشور في: |
2009
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/4043 http://dx.doi.org/10.4103/0973-1482.59917 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.cancerjournal.net/article.asp?issn=0973-1482;year=2009;volume=5;issue=4;spage=305;epage=308;aulast=Akoum |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513462837706752 |
|---|---|
| author | Farhat, Hussein |
| author2 | Khoury, Joe Mahfoud, Nathalie Akoum, Riad Mahfoud, Daniel Ghaoui, Albert |
| author2_role | author author author author author |
| author_facet | Farhat, Hussein Khoury, Joe Mahfoud, Nathalie Akoum, Riad Mahfoud, Daniel Ghaoui, Albert |
| author_role | author |
| dc.creator.none.fl_str_mv | Farhat, Hussein Khoury, Joe Mahfoud, Nathalie Akoum, Riad Mahfoud, Daniel Ghaoui, Albert |
| dc.date.none.fl_str_mv | 2009 2016-06-15T09:10:09Z 2016-06-15T09:10:09Z 2016-06-15 |
| dc.identifier.none.fl_str_mv | 0973-1482 http://hdl.handle.net/10725/4043 http://dx.doi.org/10.4103/0973-1482.59917 Akoum, R., Mahfoud, D., Ghaoui, A., Haddad, N., Mahfoud, N., Farhat, H., & Khoury, J. (2009). Budd-Chiari syndrome and heparin-induced thrombocytopenia in polycythemia vera: successful treatment with repeated TIPS and interferon alpha. Journal of cancer research and therapeutics, 5(4), 305. http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.cancerjournal.net/article.asp?issn=0973-1482;year=2009;volume=5;issue=4;spage=305;epage=308;aulast=Akoum |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Cancer research and therapeutics |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | Budd-Chiari syndrome and heparin-induced thrombocytopenia in polycythemia vera: Successful treatment with repeated TIPS and interferon alpha |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Polycythemia vera (PV) is a common cause of Budd-Chiari syndrome (BCS) and portal vein thrombosis (PVT). The postpartum period is a precipitating cofactor. An additional heparin-induced thrombocytopenia/thrombosis (HIT/T) leads to a life-threatening condition in which transjugular intrahepatic portosystemic shunting (TIPS) seems to be the only life-saving procedure. We describe the case of a subacute BCS and PVT in the late postpartum period. The diagnosis was established using CT scan, MRI, and Doppler ultrasonography of abdominal vessels and the laboratory findings were compatible with PV. After a successful creation of TIPS, a HIT/T worsened the hemorrhagic and thrombotic picture. TIPS procedure was successfully repeated and heparin was replaced with Fondaparinux and then vitamin K antagonist. The treatment with interferon alpha-2A, started after the normalization of liver functions, resulted in a complete remission within 6 months. The JAK2 V617F mutation clone remained undetectable after 2 years' follow-up. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_e42c2da3bb914a6b4bcd884399feb2a6 |
| identifier_str_mv | 0973-1482 Akoum, R., Mahfoud, D., Ghaoui, A., Haddad, N., Mahfoud, N., Farhat, H., & Khoury, J. (2009). Budd-Chiari syndrome and heparin-induced thrombocytopenia in polycythemia vera: successful treatment with repeated TIPS and interferon alpha. Journal of cancer research and therapeutics, 5(4), 305. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/4043 |
| publishDate | 2009 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Budd-Chiari syndrome and heparin-induced thrombocytopenia in polycythemia vera: Successful treatment with repeated TIPS and interferon alphaFarhat, HusseinKhoury, JoeMahfoud, NathalieAkoum, RiadMahfoud, DanielGhaoui, AlbertPolycythemia vera (PV) is a common cause of Budd-Chiari syndrome (BCS) and portal vein thrombosis (PVT). The postpartum period is a precipitating cofactor. An additional heparin-induced thrombocytopenia/thrombosis (HIT/T) leads to a life-threatening condition in which transjugular intrahepatic portosystemic shunting (TIPS) seems to be the only life-saving procedure. We describe the case of a subacute BCS and PVT in the late postpartum period. The diagnosis was established using CT scan, MRI, and Doppler ultrasonography of abdominal vessels and the laboratory findings were compatible with PV. After a successful creation of TIPS, a HIT/T worsened the hemorrhagic and thrombotic picture. TIPS procedure was successfully repeated and heparin was replaced with Fondaparinux and then vitamin K antagonist. The treatment with interferon alpha-2A, started after the normalization of liver functions, resulted in a complete remission within 6 months. The JAK2 V617F mutation clone remained undetectable after 2 years' follow-up.PublishedN/A2016-06-15T09:10:09Z2016-06-15T09:10:09Z20092016-06-15Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0973-1482http://hdl.handle.net/10725/4043http://dx.doi.org/10.4103/0973-1482.59917Akoum, R., Mahfoud, D., Ghaoui, A., Haddad, N., Mahfoud, N., Farhat, H., & Khoury, J. (2009). Budd-Chiari syndrome and heparin-induced thrombocytopenia in polycythemia vera: successful treatment with repeated TIPS and interferon alpha. Journal of cancer research and therapeutics, 5(4), 305.http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttp://www.cancerjournal.net/article.asp?issn=0973-1482;year=2009;volume=5;issue=4;spage=305;epage=308;aulast=AkoumenCancer research and therapeuticsinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/40432021-03-19T10:00:54Z |
| spellingShingle | Budd-Chiari syndrome and heparin-induced thrombocytopenia in polycythemia vera: Successful treatment with repeated TIPS and interferon alpha Farhat, Hussein |
| status_str | publishedVersion |
| title | Budd-Chiari syndrome and heparin-induced thrombocytopenia in polycythemia vera: Successful treatment with repeated TIPS and interferon alpha |
| title_full | Budd-Chiari syndrome and heparin-induced thrombocytopenia in polycythemia vera: Successful treatment with repeated TIPS and interferon alpha |
| title_fullStr | Budd-Chiari syndrome and heparin-induced thrombocytopenia in polycythemia vera: Successful treatment with repeated TIPS and interferon alpha |
| title_full_unstemmed | Budd-Chiari syndrome and heparin-induced thrombocytopenia in polycythemia vera: Successful treatment with repeated TIPS and interferon alpha |
| title_short | Budd-Chiari syndrome and heparin-induced thrombocytopenia in polycythemia vera: Successful treatment with repeated TIPS and interferon alpha |
| title_sort | Budd-Chiari syndrome and heparin-induced thrombocytopenia in polycythemia vera: Successful treatment with repeated TIPS and interferon alpha |
| url | http://hdl.handle.net/10725/4043 http://dx.doi.org/10.4103/0973-1482.59917 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.cancerjournal.net/article.asp?issn=0973-1482;year=2009;volume=5;issue=4;spage=305;epage=308;aulast=Akoum |