Regioselective formation of interlocked dicarba bridges in naturally occurring cyclic peptide toxins using olefin metathesis
Bis-dicarba analogues of native dicystine-containing α-conotoxin Rg1A, an analgesic peptide isolated from cone snail venom, were constructed on resin using a regioselective metathesis–hydrogenation strategy.
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| Other Authors: | , , , , , |
| Format: | article |
| Published: |
2009
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| Online Access: | http://hdl.handle.net/10725/2864 http://dx.doi.org/10.1039/B909056H http://pubs.rsc.org/en/content/articlehtml/2009/cc/b909056h |
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