The Clinical Impact of Immediate On-Site Cytopathology Evaluation During Endoscopic Ultrasound-Guided Fine Needle Aspiration of Pancreatic Masses
Objectives: Observational data on the impact of on-site cytopathology evaluation (OCE) during endoscopic ultrasonography-guided fine needle aspiration (EUS–FNA) of pancreatic masses have reported conflicting results. We aimed to compare the diagnostic yield of malignancy and proportion of inadequate...
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| مؤلفون آخرون: | , , , , , , , , |
| التنسيق: | article |
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2015
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/4438 http://dx.doi.org/10.1038/ajg.2015.262 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.nature.com/ajg/journal/v110/n10/full/ajg2015262a.html |
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| _version_ | 1864513463596875776 |
|---|---|
| author | Azar, Riad R. |
| author2 | Wani, Sachin Mullady, Daniel Early, Dayna S. Rastogi, Amit Collins, Brian Wang, Jeff F. Marshall, Carrie Sams, Sharon B. Yen, Roy |
| author2_role | author author author author author author author author author |
| author_facet | Azar, Riad R. Wani, Sachin Mullady, Daniel Early, Dayna S. Rastogi, Amit Collins, Brian Wang, Jeff F. Marshall, Carrie Sams, Sharon B. Yen, Roy |
| author_role | author |
| dc.creator.none.fl_str_mv | Azar, Riad R. Wani, Sachin Mullady, Daniel Early, Dayna S. Rastogi, Amit Collins, Brian Wang, Jeff F. Marshall, Carrie Sams, Sharon B. Yen, Roy |
| dc.date.none.fl_str_mv | 2015 2016-09-28T11:28:53Z 2016-09-28T11:28:53Z 2016-09-28 |
| dc.identifier.none.fl_str_mv | 0002-9270 http://hdl.handle.net/10725/4438 http://dx.doi.org/10.1038/ajg.2015.262 Wani, S., Mullady, D., Early, D. S., Rastogi, A., Collins, B., Wang, J. F., ... & Romanas, M. (2015). The Clinical Impact of Immediate On-Site Cytopathology Evaluation During Endoscopic Ultrasound-Guided Fine Needle Aspiration of Pancreatic Masses: A Prospective Multicenter Randomized Controlled Trial. The American journal of gastroenterology, 110(10), 1429 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.nature.com/ajg/journal/v110/n10/full/ajg2015262a.html |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | The American Journal of Gastroenterology |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | The Clinical Impact of Immediate On-Site Cytopathology Evaluation During Endoscopic Ultrasound-Guided Fine Needle Aspiration of Pancreatic Masses A Prospective Multicenter Randomized Controlled Trial |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Objectives: Observational data on the impact of on-site cytopathology evaluation (OCE) during endoscopic ultrasonography-guided fine needle aspiration (EUS–FNA) of pancreatic masses have reported conflicting results. We aimed to compare the diagnostic yield of malignancy and proportion of inadequate specimens between patients undergoing EUS–FNA of pancreatic masses with and without OCE. Methods: In this multicenter randomized controlled trial, consecutive patients with solid pancreatic mass underwent randomization for EUS–FNA with or without OCE. The number of FNA passes in the OCE+ arm was dictated by the on-site cytopathologist, whereas seven passes were performed in OCE− arm. EUS–FNA protocol was standardized, and slides were reviewed by cytopathologists using standardized criteria for cytologic characteristics and diagnosis. Results: A total of 241 patients (121 OCE+, 120 OCE−) were included. There was no difference between the two groups in diagnostic yield of malignancy (OCE+ 75.2% vs. OCE− 71.6%, P=0.45) and proportion of inadequate specimens (9.8 vs. 13.3%, P=0.31). Procedures in OCE+ group required fewer EUS–FNA passes (median, OCE+ 4 vs. OCE− 7, P<0.0001). There was no significant difference between the two groups with regard to overall procedure time, adverse events, number of repeat procedures, costs (based on baseline cost-minimization analysis), and accuracy (using predefined criteria for final diagnosis of malignancy). There was no difference between the two groups with respect to cytologic characteristics of cellularity, bloodiness, number of cells/slide, and contamination. Conclusions: Results of this study demonstrated no significant difference in the diagnostic yield of malignancy, proportion of inadequate specimens, and accuracy in patients with pancreatic mass undergoing EUS–FNA with or without OCE. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_e658ec04755b5d1c728d40b3fcd3ac79 |
| identifier_str_mv | 0002-9270 Wani, S., Mullady, D., Early, D. S., Rastogi, A., Collins, B., Wang, J. F., ... & Romanas, M. (2015). The Clinical Impact of Immediate On-Site Cytopathology Evaluation During Endoscopic Ultrasound-Guided Fine Needle Aspiration of Pancreatic Masses: A Prospective Multicenter Randomized Controlled Trial. The American journal of gastroenterology, 110(10), 1429 |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/4438 |
| publishDate | 2015 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | The Clinical Impact of Immediate On-Site Cytopathology Evaluation During Endoscopic Ultrasound-Guided Fine Needle Aspiration of Pancreatic MassesA Prospective Multicenter Randomized Controlled TrialAzar, Riad R.Wani, SachinMullady, DanielEarly, Dayna S.Rastogi, AmitCollins, BrianWang, Jeff F.Marshall, CarrieSams, Sharon B.Yen, RoyObjectives: Observational data on the impact of on-site cytopathology evaluation (OCE) during endoscopic ultrasonography-guided fine needle aspiration (EUS–FNA) of pancreatic masses have reported conflicting results. We aimed to compare the diagnostic yield of malignancy and proportion of inadequate specimens between patients undergoing EUS–FNA of pancreatic masses with and without OCE. Methods: In this multicenter randomized controlled trial, consecutive patients with solid pancreatic mass underwent randomization for EUS–FNA with or without OCE. The number of FNA passes in the OCE+ arm was dictated by the on-site cytopathologist, whereas seven passes were performed in OCE− arm. EUS–FNA protocol was standardized, and slides were reviewed by cytopathologists using standardized criteria for cytologic characteristics and diagnosis. Results: A total of 241 patients (121 OCE+, 120 OCE−) were included. There was no difference between the two groups in diagnostic yield of malignancy (OCE+ 75.2% vs. OCE− 71.6%, P=0.45) and proportion of inadequate specimens (9.8 vs. 13.3%, P=0.31). Procedures in OCE+ group required fewer EUS–FNA passes (median, OCE+ 4 vs. OCE− 7, P<0.0001). There was no significant difference between the two groups with regard to overall procedure time, adverse events, number of repeat procedures, costs (based on baseline cost-minimization analysis), and accuracy (using predefined criteria for final diagnosis of malignancy). There was no difference between the two groups with respect to cytologic characteristics of cellularity, bloodiness, number of cells/slide, and contamination. Conclusions: Results of this study demonstrated no significant difference in the diagnostic yield of malignancy, proportion of inadequate specimens, and accuracy in patients with pancreatic mass undergoing EUS–FNA with or without OCE.PublishedN/A2016-09-28T11:28:53Z2016-09-28T11:28:53Z20152016-09-28Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article0002-9270http://hdl.handle.net/10725/4438http://dx.doi.org/10.1038/ajg.2015.262Wani, S., Mullady, D., Early, D. S., Rastogi, A., Collins, B., Wang, J. F., ... & Romanas, M. (2015). The Clinical Impact of Immediate On-Site Cytopathology Evaluation During Endoscopic Ultrasound-Guided Fine Needle Aspiration of Pancreatic Masses: A Prospective Multicenter Randomized Controlled Trial. The American journal of gastroenterology, 110(10), 1429http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.phphttp://www.nature.com/ajg/journal/v110/n10/full/ajg2015262a.htmlenThe American Journal of Gastroenterologyinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/44382021-03-19T10:00:55Z |
| spellingShingle | The Clinical Impact of Immediate On-Site Cytopathology Evaluation During Endoscopic Ultrasound-Guided Fine Needle Aspiration of Pancreatic Masses Azar, Riad R. |
| status_str | publishedVersion |
| title | The Clinical Impact of Immediate On-Site Cytopathology Evaluation During Endoscopic Ultrasound-Guided Fine Needle Aspiration of Pancreatic Masses |
| title_full | The Clinical Impact of Immediate On-Site Cytopathology Evaluation During Endoscopic Ultrasound-Guided Fine Needle Aspiration of Pancreatic Masses |
| title_fullStr | The Clinical Impact of Immediate On-Site Cytopathology Evaluation During Endoscopic Ultrasound-Guided Fine Needle Aspiration of Pancreatic Masses |
| title_full_unstemmed | The Clinical Impact of Immediate On-Site Cytopathology Evaluation During Endoscopic Ultrasound-Guided Fine Needle Aspiration of Pancreatic Masses |
| title_short | The Clinical Impact of Immediate On-Site Cytopathology Evaluation During Endoscopic Ultrasound-Guided Fine Needle Aspiration of Pancreatic Masses |
| title_sort | The Clinical Impact of Immediate On-Site Cytopathology Evaluation During Endoscopic Ultrasound-Guided Fine Needle Aspiration of Pancreatic Masses |
| url | http://hdl.handle.net/10725/4438 http://dx.doi.org/10.1038/ajg.2015.262 http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php http://www.nature.com/ajg/journal/v110/n10/full/ajg2015262a.html |