The Candida albicans Dse1 Protein Is Essential and Plays a Role in Cell Wall Rigidity, Biofilm Formation, and Virulence
The fungal pathogen Candida albicans is one of the leading causative agents of death in immunocompromised individuals. It harbors an arsenal of cell wall anchored factors that are implicated in virulence such as filamentation inducing factors, adhesins, lipases, proteases, and superoxide dismutases....
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , |
| التنسيق: | article |
| منشور في: |
2011
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| الوصول للمادة أونلاين: | http://hdl.handle.net/10725/3373 http://dx.doi.org/10.1155/2011/504280 http://www.hindawi.com/journals/ipid/2011/504280/abs/ |
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إضافة وسم
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| _version_ | 1864513461033107456 |
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| author | Khalaf, Roy A. |
| author2 | Daher, Jalil Y. Koussa, Joseph Younes, Samer |
| author2_role | author author author |
| author_facet | Khalaf, Roy A. Daher, Jalil Y. Koussa, Joseph Younes, Samer |
| author_role | author |
| dc.creator.none.fl_str_mv | Khalaf, Roy A. Daher, Jalil Y. Koussa, Joseph Younes, Samer |
| dc.date.none.fl_str_mv | 2011 2016-03-21T09:28:51Z 2016-03-21T09:28:51Z 2016-03-21 |
| dc.identifier.none.fl_str_mv | 1687-708X http://hdl.handle.net/10725/3373 http://dx.doi.org/10.1155/2011/504280 Daher, J. Y., Koussa, J., Younes, S., & Khalaf, R. A. (2011). The Candida albicans Dse1 protein is essential and plays a role in cell wall rigidity, biofilm formation, and virulence. Interdisciplinary perspectives on infectious diseases, 2011. http://www.hindawi.com/journals/ipid/2011/504280/abs/ |
| dc.language.none.fl_str_mv | en |
| dc.relation.none.fl_str_mv | Interdisciplinary Perspectives on Infectious Diseases |
| dc.rights.*.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.title.none.fl_str_mv | The Candida albicans Dse1 Protein Is Essential and Plays a Role in Cell Wall Rigidity, Biofilm Formation, and Virulence |
| dc.type.none.fl_str_mv | Article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | The fungal pathogen Candida albicans is one of the leading causative agents of death in immunocompromised individuals. It harbors an arsenal of cell wall anchored factors that are implicated in virulence such as filamentation inducing factors, adhesins, lipases, proteases, and superoxide dismutases. Dse1 is a cell wall protein involved in cell wall metabolism. The purpose of this study is to characterize the role Dse1 plays in virulence. Dse1 appears to be an essential gene as no homozygous null mutant was possible. The heterozygote mutant exhibited increased susceptibility to calcofluor white, a cell wall disrupting agent, with a subsequent reduction in cell wall chitin content, decreased oxidative stress tolerance, a 30% reduction in biofilm formation, and a delay in adhesion that was mirrored by a reduction in virulence in a mouse model of infection. Dse1 thus appears to be an important protein involved in cell wall integrity and rigidity. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | LAURepo_e81a930821aa2e8a797df9037760e047 |
| identifier_str_mv | 1687-708X Daher, J. Y., Koussa, J., Younes, S., & Khalaf, R. A. (2011). The Candida albicans Dse1 protein is essential and plays a role in cell wall rigidity, biofilm formation, and virulence. Interdisciplinary perspectives on infectious diseases, 2011. |
| language_invalid_str_mv | en |
| network_acronym_str | LAURepo |
| network_name_str | Lebanese American University repository |
| oai_identifier_str | oai:laur.lau.edu.lb:10725/3373 |
| publishDate | 2011 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | The Candida albicans Dse1 Protein Is Essential and Plays a Role in Cell Wall Rigidity, Biofilm Formation, and VirulenceKhalaf, Roy A.Daher, Jalil Y.Koussa, JosephYounes, SamerThe fungal pathogen Candida albicans is one of the leading causative agents of death in immunocompromised individuals. It harbors an arsenal of cell wall anchored factors that are implicated in virulence such as filamentation inducing factors, adhesins, lipases, proteases, and superoxide dismutases. Dse1 is a cell wall protein involved in cell wall metabolism. The purpose of this study is to characterize the role Dse1 plays in virulence. Dse1 appears to be an essential gene as no homozygous null mutant was possible. The heterozygote mutant exhibited increased susceptibility to calcofluor white, a cell wall disrupting agent, with a subsequent reduction in cell wall chitin content, decreased oxidative stress tolerance, a 30% reduction in biofilm formation, and a delay in adhesion that was mirrored by a reduction in virulence in a mouse model of infection. Dse1 thus appears to be an important protein involved in cell wall integrity and rigidity.PublishedN/A2016-03-21T09:28:51Z2016-03-21T09:28:51Z20112016-03-21Articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1687-708Xhttp://hdl.handle.net/10725/3373http://dx.doi.org/10.1155/2011/504280Daher, J. Y., Koussa, J., Younes, S., & Khalaf, R. A. (2011). The Candida albicans Dse1 protein is essential and plays a role in cell wall rigidity, biofilm formation, and virulence. Interdisciplinary perspectives on infectious diseases, 2011.http://www.hindawi.com/journals/ipid/2011/504280/abs/enInterdisciplinary Perspectives on Infectious Diseasesinfo:eu-repo/semantics/openAccessoai:laur.lau.edu.lb:10725/33732016-07-29T06:54:24Z |
| spellingShingle | The Candida albicans Dse1 Protein Is Essential and Plays a Role in Cell Wall Rigidity, Biofilm Formation, and Virulence Khalaf, Roy A. |
| status_str | publishedVersion |
| title | The Candida albicans Dse1 Protein Is Essential and Plays a Role in Cell Wall Rigidity, Biofilm Formation, and Virulence |
| title_full | The Candida albicans Dse1 Protein Is Essential and Plays a Role in Cell Wall Rigidity, Biofilm Formation, and Virulence |
| title_fullStr | The Candida albicans Dse1 Protein Is Essential and Plays a Role in Cell Wall Rigidity, Biofilm Formation, and Virulence |
| title_full_unstemmed | The Candida albicans Dse1 Protein Is Essential and Plays a Role in Cell Wall Rigidity, Biofilm Formation, and Virulence |
| title_short | The Candida albicans Dse1 Protein Is Essential and Plays a Role in Cell Wall Rigidity, Biofilm Formation, and Virulence |
| title_sort | The Candida albicans Dse1 Protein Is Essential and Plays a Role in Cell Wall Rigidity, Biofilm Formation, and Virulence |
| url | http://hdl.handle.net/10725/3373 http://dx.doi.org/10.1155/2011/504280 http://www.hindawi.com/journals/ipid/2011/504280/abs/ |